Abstract: The disclosure discloses an ultrasonic-assisted pretreatment method for extraction of multiple steroid hormones in a sediment, including the following steps: (1) lyophilizing the sediment, grinding the sediment, and passing the ground sediment through a 40-60-mesh sieve; (2) placing the sample obtained in step (1) in a container; (3) adding an extractant to the container in step (2), shaking the mixture for 15 s-30 s, centrifuging the mixture to collect an supernatant after ultrasonication, and repeating extraction three times; where the extractants used in the three times of extraction are two of methanol, acetonitrile and acetone; and (4) after mixing the supernatants of the three times of extraction obtained in step (3), concentrating the mixture under a nitrogen flow at 20-30° C., passing the concentrated mixture through a filter, and performing detection. By using the method of the disclosure, the maximum recovery can be up to 100%.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: The disclosure discloses a preparation method and product of carbon fiber reinforced polymer composites with a designable characteristic structure. The method includes: (a) choosing carbon fabrics as raw material, where a predetermined number of the fabrics are selected to deposit the reinforcement phase; (b) coating all carbon fabrics with resin matrix, placing the fabrics layer by layer, where the carbon fabrics with the reinforcement phases are placed in a predetermined layer, meanwhile a micro power supply is placed in a setting layer during the stacking process, then a prefabricated product is obtained; (c) placing the prefabricated product in a vacuum bag then evacuating and sealing, hot pressing the sealed prefabricated product, finally the carbon fiber reinforced polymer composite product in the vacuum bag after hot pressing is successfully manufactured.

Abstract: Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.

Abstract: Embodiments of the disclosure provide an information processing method, an information processing apparatus, and a storage medium. The method includes: obtaining source data; encoding sub-data in the source data based on a target word feature vector to obtain hidden feature vectors corresponding to the sub-data, the target word feature vector representing a sentiment feature standard; obtaining a word feature vector corresponding to the source data based on the hidden feature vectors corresponding to the sub-data; and inputting the word feature vector into a preset sentiment classification network to obtain a result of sentiment polarity prediction of the source data. According to the embodiments of the disclosure, the accuracy of sentiment polarity prediction may be improved.

Abstract: The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the dimeter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.

Abstract: An electronic device is disclosed. In one aspect, the electronic device includes a printed circuit board (PCB) having a first surface and a second surface opposite the first surface, where the PCB includes a thermally conductive region having a plurality of vias that extend from the first surface to the second surface; a semiconductor device attached to the second surface of the PCB and overlying the thermally conductive region; a transformer having a magnetic core; a shield arranged to partially enclose the transformer and define an opening; and an insert disposed within the opening, attached to the first surface of the PCB and overlying the thermally conductive region.

Abstract: Disclosed herein is a waterborne polyurethane-epoxy resin-based primer composition and its preparation method. Further disclosed herein is a primer layer obtained from curing the waterborne polyurethane-epoxy resin-based primer composition on substrates as well as a method of curing the primer composition on substrates.

Abstract: Systems and methods for improving radiated electromagnetic interference (EMI) in switching power supplies are disclosed. In one aspect, a converter circuit includes a transformer having a primary winding and a secondary winding, the primary winding extending from a first primary terminal to a second primary terminal, a first switch having a first gate terminal, a first source terminal and a first drain terminal, wherein the first drain terminal is coupled to the first primary terminal, and the first source terminal is coupled to a power source, and a capacitor having a first capacitor terminal and second capacitor terminal, wherein the first capacitor terminal is coupled to the power source. A ferrite bead is coupled between the first primary terminal and the first drain terminal, and a capacitor network is coupled in parallel with the ferrite bead and arranged to reduce radiated electromagnetic interference of the converter circuit.

Abstract: An electric space heater having foldable panels is disclosed. A foldable panel may comprise a plural plate-like members and a flexible non-conductive material. The plural plate-like members including (i) a first plate-like member, a second plate-like member, a third plate-like member. The first plate-like member may have a heating element having a first radiation emitting surface and a second interior surface, and (b) a board adhesively bonded to said second interior surface; the second plate-like member may have (a) a heating element having a first radiation emitting surface and a second interior surface, and (b) a board adhesively bonded to said second interior surface; the third plate-like member may have (a) a heating element having a first radiation emitting surface and a second interior surface, and (b) a board adhesively bonded to said second interior surface.

Abstract: The present invention discloses a 400 MPa corrosion-resistant steel bar and a production method thereof. The steel bar includes the following chemical ingredients: 9.5-10.4% of Cr, 1.0-1.2% of Mo, 0.3-0.6% of Mn, 0.01-1% of Ni, 0.01-0.5% of Cu, at most 0.014% of C, at most 0.004% of N, 0.01-0.05% of Nb, 0.2-0.6% of Si, and the balance of Fe, where Cr+Mo+0.5Mn+0.35Ni+0.25Cu is 11.1-12.2%, and C+N+0.3Si+Mn+1.8Nb is 0.4-0.8%.

Abstract: A low power-loss supply circuit minimizes the losses in a synchronous rectifier power conversion circuit by regulating the voltage supply (Vcc) of a synchronous rectifier controller. The low power-loss supply circuit uses two regulating capacitors to regulate the value of the voltage supplied to the controller. A first regulating capacitor supplies the input voltage which powers the synchronous rectifier controller. A second regulating capacitor is used to cyclically charge the first regulating capacitor.

Abstract: An optical module comprising a pull ring, a rotating fork, an unlocking body provided with a fork opening, and a base, on which a protrusion used for coupling with a lock hole of an interface device to lock the optical module on the interface device is arranged, wherein the unlocking body is arranged on the base and connected to the rotating fork, and the rotating fork is movably connected to the base and is connected with the pull ring. The pull ring drives the rotating fork to rotate along the base, and the rotating fork pushes the unlocking body to move towards the protrusion in the rotating process until the fork opening abuts and opens the lock hole of the interface device, then the protrusion is decoupled from the lock hole of the interface device, thus realizing an unlocking function, thereby improving the reliability of the optical module.

Abstract: Disclosed are a multi-granularity perception integrated learning method, a device, a computer equipment and a storage medium.

Abstract: A method and system of two-point correction based on temperature substitution, includes: a black body related to the lens temperature is arranged outside a lens, a first black body arranged in front of the lens of an infrared thermal camera, so as to collect a gray value of the first black body; a temperature of the first black body being equal to the lens temperature; a second black body arranged in front of the lens of the infrared thermal camera, so as to collect a gray value of the second black body; a temperature of the second black body being higher than the lens temperature. Two correction parameters obtained by black body calculation related to temperature are strongly applicable, which eliminates the problem of image quality deterioration caused by temperature changes and greatly eliminates the pot lid phenomenon due to non-uniformity, thereby accurately calculating the corrected gray value.

Abstract: A resilient prestress-free steel structure includes the elastic centering beam and two pin-ended box column bases. The elastic centering beam includes two cantilever segment I-shaped steel beams, a middle segment I-shaped steel beam and buckling restrained high strength steel bars. The cantilever segment I-shaped steel beams are fixed to the two pin-ended box column bases, the middle segment I-shaped steel beam is connected between the two cantilever segment I-shaped steel beams, the buckling restrained high strength steel bars are symmetrically arranged. One end of each of the buckling restrained high strength steel bars is firmly connected with the web of each of the cantilever segment I-shaped steel beams, and the other end of each of the buckling restrained high strength steel bars is firmly connected with the web of the middle segment I-shaped steel beam. The resilient prestress-free steel structure is arranged in left and right symmetrical manner.

Abstract: A method of using a catheter includes removing a packaging enclosing the catheter and a fluid reservoir. The catheter removed from the packaging includes a catheter housing defining an interior lumen, an ultrasound transducer disposed within the interior lumen, and a first fluid medium within the interior lumen. The fluid reservoir removed from the packaging includes a second fluid medium. After removing the packaging, a fluid outlet is created at the interior lumen and the catheter is connected to an imaging engine and delivered to a region of interest. Ultrasound energy is emitted from the ultrasound transducer into the region of interest. At least a portion of the second fluid medium is delivered from the fluid reservoir to the interior lumen and at least a portion of the first fluid medium is thereby expelled from the interior lumen through the fluid outlet.