Abstract: The present disclosure provides, among other things, a method of treating Fabry disease in a subject, the method comprising administering to a subject in need thereof a recombinant adeno-associated viral vector (rAAV) packaged in AAV capsid having broad tissue tropism, the vector comprising: (a) a 5? inverted terminal repeat; (b) a ubiquitous promoter; (c) a nucleotide sequence encoding wild-type ?-GAL enzyme or a variant thereof; (d) optionally a woodchuck hepatitis virus posttranscriptional regulatory element (WPRE); (e) a poly A; and (d) a 3?ITR.

Abstract: The present invention relates to: a pyrene derivative compound having a specific structure; and a high efficiency organic light-emitting device employing the pyrene derivative compound in a light emitting layer and thus having excellent light-emitting characteristics. The organic light-emitting device according to the present invention can be configured as a high efficiency organic light-emitting device having excellent light-emitting characteristics by employing the pyrene derivative compound having the specific structure as a host in the light emitting layer, and thus can be usefully applied industrially in lighting devices, as well as various display devices such as flat, flexible, and wearable displays.

Abstract: An organic light-emitting device according to the present invention uses a pyrene derivative compound having a characteristic structure as a host in a light-emitting layer to realize a long-lifespan and high-efficiency organic light-emitting device having excellent light-emitting characteristics in terms of lifespan and luminescence efficiency. Accordingly, the organic light-emitting device can be usefully applied, in the industrial aspect, for various display devices such as flat panel, flexible, and wearable displays, as well as lighting devices.

Abstract: The present disclosure relates to a boron compound useful in an organic light-emitting diode and an organic light-emitting diode comprising same and, more particularly, to a boron compound represented by any one of [Chemical Formula A], wherein [Chemical Formula A] is as defined in the description.

Abstract: The present invention provides a pharmaceutical composition for prevention or treatment of a stress disease and depression, the pharmaceutical composition be safely useable without toxicity and side effects by using an extract of leaves of Vaccinium bracteatum Thunb., which is natural resource of Korea, so that the reduction of manufacturing and production costs and the import substitution and export effects can be expected through the replacement of a raw material for preparation with a plant inhabiting in nature.

Abstract: The present invention relates to a novel heterocyclic compound usable in an organic light-emitting device and to an organic light-emitting device comprising same, wherein [chemical formula A] is as described in the detailed description of the invention.

Abstract: Disclosed is a polycyclic aromatic compound that can be employed in an organic layer of an organic electroluminescent device. Also disclosed is a highly efficient organic electroluminescent device including the polycyclic aromatic compound. The use of the polycyclic aromatic compound significantly improves the luminous efficiency of the device.

Abstract: In some embodiments, an electronic device detects a first user input corresponding to a request to search for an additional destination in a multi stop route, and the location on which the search is centered depends on whether or not navigation along the route is ongoing.

Abstract: The present invention relates to a composition for preventing or treating benign prostatic hyperplasia, comprising fruit extracts of Elaeagnus multiflora Thunb. The fruit extracts of Elaeagnus multiflora Thunb. according to the present invention inhibited the production of 5-alpha reductase-2, prostate-specific antigen (PSA), and 5-alpha-reductase-2 in vitro, and also suppressed the enlargement of prostate tissues and the contents of 5-alpha reductase and prostate-specific antigen (PSA) in a testosterone-induced prostatic hyperplasia rat model, thereby enhancing the excellent effect of preventing or suppressing prostatic hyperplasia even in animal models, and thus have industrial applicability.

Abstract: An organic light-emitting display device includes a data driver which supplies a data voltage to a data line of each sub-pixel, and senses a driving voltage of each sub-pixel through each sensing line connected to a sub-pixel, and generates sensed data based on the driving voltage of each sub-pixel. Further, the organic light-emitting display device includes a controller that generates a reference parameter for compensating for each of operation characteristics of each sub-pixel using the sensed data generated from the data driver, and compensates for image data based on the reference parameter and outputs the compensated image data. The controller controls the gate driver and the data driver so that sensed data is additionally generated, and compensates for and outputs the image data based on a compensation parameter extracted based on the additionally generated sensed data, thereby controlling execution of external compensation based on temperature and deterioration characteristics.

Abstract: A pharmaceutical composition and a health functional food composition for alleviating eye fatigue containing, as active ingredients, compounds, particularly, luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide isolated from a Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo leaf extract have an effect of alleviating eye fatigue by increasing the contents of NO and cGMP associated with relaxation of ciliary smooth muscle cells isolated from rat's eyes and decreasing the content of [Ca2+]i, and increasing cGMP which is a factor associated with relaxation of the ciliary smooth muscle through an animal experiment. As a result, the luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds extracted from Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo may be usefully used as a pharmaceutical composition and a health functional food composition having an eye fatigue alleviating effect as a Korean natural resource.

Abstract: An organic light-emitting display device includes a data driver which supplies a data voltage to a data line of each sub-pixel, and senses a driving voltage of each sub-pixel through each sensing line connected to a sub-pixel, and generates sensed data based on the driving voltage of each sub-pixel. Further, the organic light-emitting display device includes a controller that generates a reference parameter for compensating for each of operation characteristics of each sub-pixel using the sensed data generated from the data driver, and compensates for image data based on the reference parameter and outputs the compensated image data. The controller controls the gate driver and the data driver so that sensed data is additionally generated, and compensates for and outputs the image data based on a compensation parameter extracted based on the additionally generated sensed data, thereby controlling execution of external compensation based on temperature and deterioration characteristics.

Abstract: The present invention, it was confirmed that a pharmaceutical composition and a health functional food composition for alleviating eye fatigue containing, as active ingredients, compounds, particularly, luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide isolated from a Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo leaf extract have an effect of alleviating eye fatigue by increasing the contents of NO and cGMP associated with relaxation of ciliary smooth muscle cells isolated from rat's eyes and decreasing the content of [Ca2+]i, and increasing cGMP which is a factor associated with relaxation of the ciliary smooth muscle through an animal experiment. As a result, the luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds extracted from Perilla frutescens (L.) Britton var. acuta (Thunb.) Kudo may be usefully used as a pharmaceutical composition and a health functional food composition having an eye fatigue alleviating effect as a Korean natural resource.

Abstract: The present invention provides a health functional food composition and a pharmaceutical composition for preventing and alleviating depression, both compositions using an extract of Vaccinium bracteatum Thunb. fruits, which are Korean natural resources, so as to be safely usable without toxicity and side effects.

Abstract: The present invention provides devices, systems and methods relating to a storage space of a residential consumer after the purchase of an article, and is particularly suitable for ensuring that the storage space to which the carrier delivers the purchase/parcel is a secured space. The secured space includes a receptacle etc. and the cover/door of the receptacle, and a locking mechanism installed on the receptacle and/or the cover/door, which can only be opened by authorized persons/devices. The locking mechanism may include a unique identification and be controlled by a secured device to unlock. The secured device can communicate with access management servers, authorized device or carrier device, etc. The receptacle may be disposed on a folding cart that can be placed outside the house by a lock mode fixing device, an attachment mode fixing device, an embed mode fixing device, a through mode fixing device or an implant mode fixing device.

Abstract: Aspects of the subject disclosure may include, for example, obtaining configuration update messages received from neighbor cells of a serving cell of a wireless network, wherein the configuration update messages include dual connectivity capability information of the neighbor cells. The neighbor cells are ranked according to the dual connectivity capability information resulting in a dual connectivity ranking. A target cell of the neighbor cells is selected according to the dual connectivity ranking and a dual connectivity capability of a mobile device, and a dual connectivity service is established according to the dual connectivity ranking. The dual connectivity service includes exchanging user plane messages between the mobile device, a master cell and a secondary cell of the wireless network. Other embodiments are disclosed.

Abstract: An adaptive coordinator system in a self-organizing network, the system comprising a network coordinator communicating with a policy engine, the policy engine including a dynamic policy that governs at least one microservice, the network coordinator communicating with the at least one microservice; a machine learning tool in communication with the network coordinator and the plural microservices; the network coordinator including a decision algorithm establishing at least one trigger condition based on the dynamic policy, wherein when the network coordinator detects the at least one trigger condition, the network coordinator performs an action; and wherein the network coordinator communicates the action to the machine learning tool to monitor implementation of the at least one microservice according to the action, and wherein the machine learning tool generates a revised action based on implementation of the action on the plural microservices, and wherein the microservice coordinator reports the revised actio