Abstract: Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

Abstract: An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.

Abstract: The invention relates to a polyurethane bone-tendon graft biomaterial and method of making the bone-tendon graft biomaterial. The biomaterial has a gradient of mechanical properties through photocrosslinking such that a first end of the biomaterial is crosslinked at a higher degree than a second end, and the first end of the biomaterial has mechanical properties of bone and the second end of the biomaterial has mechanical properties of tendon.

Abstract: Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

Abstract: A stable injectable collagen-based hydrogel delivery platform and method is provided to obtain the viscosity, post-injection stability and mechanical properties needed of an injectable collagen matrix via incorporating alginate and calcium sulfate (CaSO4) into the matrix. The hydrogel (Alg/Col hydrogel) is shear-thinning, injectable through commercially available needles and stable right after injection.

Abstract: A graft scaffold geometry is provided for use in the repair of segmental large bone defect. The scaffold geometry has a first (central) conduit with one or several hook-shaped chamber, which form a second conduit, integrated to the lateral side of the scaffold. The purpose of the hook-shaped chamber(s) is three-fold: 1) to facilitate the insertion and containment of biological augmentation constructs, such as growth factor-impregnated carrier devices; 2) stabilize the local surrounding soft tissue envelope to allow ingrowth of new blood vessels; and 3) to improve the manipulation of the composite bone free flap during implantation. Whether one or all of these mechanisms are active in a given situation, the overall result is that the hook chamber enables enhanced containment of graft-augmenting synthetic osteoinductive constructs, prevents their displacement, and maintains their proximity to the scaffold, thus improving the chances of success of the graft.

Abstract: A graft scaffold geometry is provided for use in the repair of segmental large bone defect. The scaffold geometry has a first (central) conduit with one or several hook-shaped chamber, which form a second conduit, integrated to the lateral side of the scaffold. The purpose of the hook-shaped chamber(s) is three-fold: 1) to facilitate the insertion and containment of biological augmentation constructs, such as growth factor-impregnated carrier devices; 2) stabilize the local surrounding soft tissue envelope to allow ingrowth of new blood vessels; and 3) to improve the manipulation of the composite bone free flap during implantation. Whether one or all of these mechanisms are active in a given situation, the overall result is that the hook chamber enables enhanced containment of graft-augmenting synthetic osteoinductive constructs, prevents their displacement, and maintains their proximity to the scaffold, thus improving the chances of success of the graft.

Abstract: An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.

Abstract: The invention relates to a polyurethane bone-tendon graft biomaterial and method of making the bone-tendon graft biomaterial. The biomaterial has a gradient of mechanical properties through photocrosslinking such that a first end of the biomaterial is crosslinked at a higher degree than a second end, and the first end of the biomaterial has mechanical properties of bone and the second end of the biomaterial has mechanical properties of tendon.

Abstract: An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.

Abstract: The invention relates to a polyurethane bone-tendon graft biomaterial and method of making the bone-tendon graft biomaterial. The biomaterial has a gradient of mechanical properties through photocrosslinking such that a first end of the biomaterial is crosslinked at a higher degree than a second end, and the first end of the biomaterial has mechanical properties of bone and the second end of the biomaterial has mechanical properties of tendon.

Abstract: The invention relates to a polyurethane bone-tendon graft biomaterial and method of making the bone-tendon graft biomaterial. The biomaterial has a gradient of mechanical properties through photocrosslinking such that a first end of the biomaterial is crosslinked at a higher degree than a second end, and the first end of the biomaterial has mechanical properties of bone and the second end of the biomaterial has mechanical properties of tendon.

Abstract: A simultaneous thermoplastic and thermoset deposition system is provided that includes a substrate holder, a thermoplastic molten-material extruder, photo-polymerizing light source, a prepolymer vat, and a controller, where the controller controls the thermoplastic extruder to deposit a thermoplastic layer according to a thermoplastic pattern on the substrate holder, where the controller controls the substrate holder to immerse the thermoplastic layer in the prepolymer vat for coating the thermoplastic layer with a coating of the prepolymer solution, where the controller controls the substrate holder to position the prepolymer coated thermoplastic layer for exposure to the photo-polymerizing light source, where the controller controls the photo-polymerizing light source to cure the prepolymer coating according to a thermoset pattern on the thermoplastic layer, where the controller iteratively controls the substrate holder, the thermoplastic molten-material extruder, and the photo-polymerizing light source to

Abstract: An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.

Abstract: Provided is a method of using a light sensor earphone to control an electronic device. The method includes: a light sensor earphone detecting light intensity of an ear close side and light intensity of an ear outer side according to a received light signal; comparing the light intensity of the close ear side with the light intensity of the ear outer side, and generating an electric signal corresponding to a current mode of an electronic device according to a comparison result; and sending the electric signal to the electronic device, for the electronic device to control a corresponding function in the current mode according to the electric signal. A light sensor earphone is also provided. By means of the technical solutions, the light sensor earphone is utilized to intelligently control corresponding functions of the electronic device so as to simplify operation.

Abstract: Aspects of the present disclosure include methods for preparing crosslinked polydepsipeptide copolymers by stereolithography (e.g., 3-D printing). In practicing methods according to certain embodiments, a crosslinkable copolymer containing a depsipeptide having one or more hydrolysable crosslinkers is photocrosslinked by stereolithography to produce a crosslinked polydepsipeptide copolymer. In certain embodiments, methods include contacting the crosslinkable poly(depsipeptide-co-?-caprolactone) copolymer precursor with one or more bioactive agents and photocrosslinking by 3-D printing to produce a crosslinked poly(depsipeptide-co-?-caprolactone) copolymer with incorporated bioactive agent. Crosslinkable polydepsipeptide copolymer precursors and crosslinked polydepsipeptide copolymers are also described.

Abstract: Provided is a method of using a light sensor earphone to control an electronic device. The method includes: a light sensor earphone detecting light intensity of an ear close side and light intensity of an ear outer side according to a received light signal; comparing the light intensity of the close ear side with the light intensity of the ear outer side, and generating an electric signal corresponding to a current mode of an electronic device according to a comparison result; and sending the electric signal to the electronic device, for the electronic device to control a corresponding function in the current mode according to the electric signal. A light sensor earphone is also provided. By means of the technical solutions, the light sensor earphone is utilized to intelligently control corresponding functions of the electronic device so as to simplify operation.

Abstract: Ceramic porous and non-porous articles are made by a process that includes a hardening step in which a fluid-containing ceramic composition is exposed to a solvent in which the fluid in the composition is soluble before the ceramic composition is solidified into the final ceramic article.

Abstract: Ceramic articles as functional biodegradable scaffolds with graded porosity are made by a process that includes a hardening step in which the liquid of a liquid-containing ceramic composition is extracted from the ceramic composition by exposing the ceramic composition to a solvent in which the liquid in the composition is soluble before the ceramic composition is solidified into the final ceramic article. An exemplary calcium phosphate porous ceramic article constructed in accordance with the process is useful as an implant to repair a bone defect.

Abstract: Ceramic porous and non-porous articles are made by a process that includes a hardening step in which a fluid-containing ceramic composition is exposed to a solvent in which the fluid in the composition is soluble before the ceramic composition is solidified into the final ceramic article.