Patents by Inventor Yushen Du

Yushen Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genome-wide identification of immune evasion functions in a virus
    Patent number: 11944679
    Abstract: A protocol has been developed for genetically engineering an attenuated pathogen such as the influenza virus that can grow in cells without interferons but has suppressed growth in cells with the interferons. The protocol comprises systematically identifying immune evasion functions on the pathogen's genome, then eliminating the immune evasion functions while maintaining a certain replication fitness of the pathogen. The resulting attenuated pathogen causes a strong immunologic response and can be used in a live attenuated vaccine.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 2, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yushen Du, Nicholas C. Wu, Ren Sun
  • POINT-OF-CARE DIAGNOSTIC FOR DETECTING THE NUCLEOCAPSID PROTEIN OF SARS-COV-2
    Publication number: 20230305004
    Abstract: In various embodiments methods to improve the detection of a lateral-flow immunoassay for the sensitive detection of the SARS-CoV-2 nucleocapsid protein or other analytes, as well as devices that incorporate those methods are provided.
    Type: Application
    Filed: August 16, 2021
    Publication date: September 28, 2023
    Applicant: The Regents of the University of California
    Inventors: Daniel Takashi Kamei, Daniel William Bradbury, Ren Sun, Yushen Du, Benjamin Ming Wu, Jasmine Thanh Trinh, Milo Ryan, Cassandra Marie Cantu
  • GENOME-WIDE IDENTIFICATION OF IMMUNE EVASION FUNCTIONS IN A VIRUS
    Publication number: 20200129612
    Abstract: A protocol has been developed for genetically engineering an attenuated pathogen such as the influenza virus that can grow in cells without interferons but has suppressed growth in cells with the interferons. The protocol comprises systematically identifying immune evasion functions on the pathogen's genome, then eliminating the immune evasion functions while maintaining a certain replication fitness of the pathogen. The resulting attenuated pathogen causes a strong immunologic response and can be used in a live attenuated vaccine.
    Type: Application
    Filed: March 14, 2018
    Publication date: April 30, 2020
    Applicant: The Regents of the University of California
    Inventors: Yushen Du, Nicholas C. Wu, Ren Sun