Abstract: The present invention belongs to the technical field of biomedical formulations. Provided are a temperature sensitive gel damage repair formulation and an application thereof. The formulation includes 0.01-5 mg/mL rHSA/EGF, 1.9-2.6% m/m glycine, 3.9-6.2% m/m poloxamer 188, 16.3-18.2% m/m poloxamer 407, and 0.5-100 mM phosphate buffer.

Abstract: Provided is a fusion protein of human serum albumin or a wild type thereof and human interleukin-2 or a mutation thereof, said fusion protein has a significantly extended in vivo half-life relative to recombinant interleukin-2, can be used alone for treating a tumor, and improves anti-tumor efficacy of an anti-PD-1 antibody or an anti PD-L1-antibody.

Abstract: A method and system for real-time prediction of jamming in TBM tunneling. The method includes: (1) obtaining actually measured TSP physical property parameters by applying a TSP method; (2) analyzing value ranges and change trends of the TSP physical property parameters obtained in real time; (3) establishing a TSP physical property parameter sample database of a TBM tunnel; (4) establishing a mapping relationship between TSP physical property parameters and occurrence or not of jamming; (5) establishing a mapping relationship between time sequence values of tunneling parameters and occurrence or not of jamming; and (6) forecasting a TBM jamming risk in real time, and storing reliable data into the TSP physical property parameter sample database. The method and system can effectively obtain a state of surrounding rocks in time, thereby providing real-time forecasting of TBM tunneling jamming, avoiding occurrence of accidents to some extent, and improving the TBM tunneling efficiency.