Abstract: It is an object to provide an antibody specifically binding to CD37-positive tumor cells such as malignant B-cell lymphoma, an antibody-drug conjugate comprising the antibody, a pharmaceutical composition having therapeutic effects on a tumor using the antibody, a method for treating a tumor using the aforementioned pharmaceutical composition, a method for producing the antibody, and a method for producing the antibody-drug conjugate, and the like. The present invention provides an anti-CD37 antibody-drug conjugate in which an antibody is conjugated to a drug linker represented by the following formula (wherein A represents a connecting position to the antibody) by a thioether bond, specifically, a humanized anti-CD37 antibody having internalization ability and an antibody-drug conjugate containing the antibody.

Abstract: A substrate processing apparatus includes a substrate holding unit, a rotation driving unit, a first rotational ring, a second rotational ring, and a first nozzle. The substrate holding unit includes a base plate and a plurality of gripping units that grips a peripheral edge of a substrate, and horizontally holds the substrate spaced apart from the base plate by the gripping units. The rotation driving unit rotates the substrate holding unit. The first rotational ring surrounds a peripheral edge of a lower surface of the substrate and rotates together with the substrate holding unit. The second rotational ring is provided outside the first rotational ring, surrounds a peripheral edge of an upper surface of the substrate, and rotates together with the substrate holding unit. The first nozzle ejects a cleaning liquid from above an entrance of a rotational flow path toward the entrance of the rotational flow path.

Abstract: A light-emitting element includes an anode electrode, a QD layer containing QDs, and a cathode electrode, in which the QDs are Cd-free quantum dots having a core-shell structure including a core containing at least Ag, Ga, and at least one of S and Se, and a shell containing at least Zn, and exhibit fluorescence characteristics with a fluorescence full-width at half-maximum of 40 nm or less and a fluorescence quantum yield percentage of 70% or more.

Abstract: A cartridge includes a first unit including a photosensitive member, and a second unit including a developer bearing member and a force receiving portion, the second unit being configured to be rotatable about a first axis to move with respect to the first unit between a first position and a second position. In a state where the first unit is in a same posture as when an image forming operation is performed, the second unit is disposed at the second position by its own weight. The developer bearing member is configured to be rotatable about a second axis. When seen in the direction of the first axis, a first distance between the force receiving portion and the second axis is smaller than a second distance between the first axis and the second axis and a third distance between the first axis and the force receiving portion.

Abstract: A substrate processing apparatus that supplies a processing liquid to a front surface of a substrate which is rotating, includes: a substrate holder configured to hold the substrate, wherein the substrate holder includes: a gripper configured to come into contact with a periphery of the substrate to grip the substrate; and a base to which the gripper is attached.

Abstract: The present invention provides a method for manufacturing diamond, comprising electrolytically reducing carbon dioxide into diamond to obtain diamond in an electrolytic reduction apparatus having an anode, a cathode, and an electrolytic solution containing carbon dioxide, wherein the electrolytic solution comprises an ionic liquid.

Abstract: A substrate processing apparatus includes: a temperature raising part for raising a temperature of a first sulfuric acid; a mixing part for mixing the first sulfuric acid where the temperature is raised by the temperature raising part with a moisture-containing liquid to generate a mixed solution; and a discharging part for discharging the mixed solution onto a substrate inside a substrate processing part. The mixing part includes: a joining portion where a sulfuric acid supply line through which the first sulfuric acid where the temperature is raised by the temperature raising part flows and a liquid supply line through which the first sulfuric acid where the temperature is raised by the temperature raising part and the moisture-containing liquid flows are joined; and a reaction suppression mechanism for suppressing a reaction between the first sulfuric acid and the moisture-containing liquid in the joining portion.

Abstract: A light-emitting element includes an anode electrode, a cathode electrode, and a QD layer provided between the anode electrode and the cathode electrode, the QD layer containing the QDs. The QDs are AgInxGa1-xSySe1-y-based or ZnAgInxGa1-xSySe1-y-based Cd-free QDs (0?x<1, 0?y?1) and exhibit fluorescence characteristics having a fluorescent half width of 45 nm or less and a fluorescence quantum yield of 35% or more in a green wavelength region to a red wavelength region.

Abstract: A lead member includes a lead conductor having a first main surface and a second main surface opposite to the first main surface. The lead member includes a resin portion that covers the first main surface, the second main surface, and two side surfaces that are between both ends of the lead conductor, while exposing the both ends of the lead conductor in a first direction. The lead conductor includes a metal substrate and a surface treatment layer formed on at least a portion of a surface of the metal substrate, the surface treatment layer including chromium, oxygen, and fluorine. A moisture content of a portion of the surface treatment layer exposed from the resin portion, as measured by coulometric Karl Fischer titration at a vaporization temperature of 220° C., is 5.0 ?g/cm2 or less.

Abstract: An imaging processing apparatus according to one embodiment of the disclosure includes an extractor that extracts a feature quantity included in a captured image, and an object identifier that identifies an object on the basis of the feature quantity. The extractor extracts the feature quantity by executing, on the basis of the captured image, a convolution calculation using a filter including multiple filter values that are arranged two-dimensionally. The multiple filter values in the filter are set at respective values that are line-symmetric with respect to an axis of symmetry along a predetermined direction.

Abstract: The present invention aims to provide an electrophoresis apparatus which makes it possible to execute protein analysis with a high throughput. The electrophoresis apparatus according to the present invention is equipped with a capillary array which is configured by arraying a plurality of capillaries, a measurement light irradiation unit which irradiates with measurement light, a first lens array which includes a plurality of first lenses which are arrayed in correspondence with the plurality of capillaries, a second lens array which includes a plurality of second lenses which are arrayed in correspondence with the plurality of capillaries, and a light receiving unit which receives light which is incident upon the capillaries via the first lens array from the measurement light irradiation unit via the second lens array.

Abstract: A vehicle exterior environment recognition apparatus includes a stereo speed derivation unit, a monocular speed derivation unit, a predicted speed derivation unit, a mixture ratio derivation unit, and an object speed derivation unit. The stereo speed derivation unit derives a stereo speed indicating a speed of a three-dimensional object extracted from a distance image derived from luminance images of two image-capturing units. The monocular speed derivation unit derives a monocular speed indicating a speed of the three-dimensional object extracted from the luminance image of one of the image-capturing units. The predicted speed derivation unit derives a predicted speed based on a past speed of the three-dimensional object. The mixture ratio derivation unit derives a mixture ratio of the stereo, monocular, and predicted speeds. The object speed derivation unit mixes the stereo, monocular, and predicted speeds at the mixture ratio, to derive an object speed.

Abstract: Provided is a method for generating a trained model for classifying blocking event data representing nanopore blocking events in a biomolecule measurement device. The method includes generating a first trained model by executing machine learning of a training model using first teacher data, the first teacher data includes teacher blocking event data and a teacher label, the teacher label indicates whether the teacher blocking event data is classified as Good data or bad data, and the first trained model is configured to classify the blocking event data into good data or bad data. In addition, a method for determining a base sequence a biomolecule and a biomolecule measurement device are provided.

Abstract: The present invention aims to provide an electrophoresis apparatus which makes it possible to execute protein analysis with a high throughput. The electrophoresis apparatus according to the present invention is equipped with a capillary array which is configured by arraying a plurality of capillaries, a measurement light irradiation unit which irradiates with measurement light, a first lens array which includes a plurality of first lenses which are arrayed in correspondence with the plurality of capillaries, a second lens array which includes a plurality of second lenses which are arrayed in correspondence with the plurality of capillaries, and a light receiving unit which receives light which is incident upon the capillaries via the first lens array from the measurement light irradiation unit via the second lens array.

Abstract: A biomolecule is more easily and reliably reciprocated in a nanopore. An adapter molecule that directly or indirectly binds to a biomolecule to be analyzed comprises a three-dimensional structure formation domain consisting of a single-stranded nucleotide.

Abstract: An image processing apparatus includes an extractor and an object identifier. The extractor extracts a left feature quantity included in a left image of a stereo image and a right feature quantity included in a right image of the stereo image by executing a convolution calculation multiple times on the basis of the left and right images with securing horizontal symmetry between the left feature quantity and the right feature quantity, and executes, at the convolution calculation, a concatenation process of concatenating pixel values between the left feature quantity and the right feature quantity using a calculation process to secure the horizontal symmetry. The object identifier performs object identification of an object on the basis of the left feature quantity and the right feature quantity.

Abstract: In a base sequence determination system that performs a complementary strand synthesis reaction of a template DNA strand using DNA polymerase, a complementary strand synthesized by DNA polymerase is degraded by exonuclease in a solution.

Abstract: An apparatus for storing a thin film device, the apparatus including: a thin film device 3 having an insulating thin film containing Si and having a thickness of 100 nm or less; a solution in contact with the thin film; and a container having a tank that seals the solution, wherein the solution is a solution that satisfies any of the following conditions (1) to (3). (1) A solution containing water in a volume ratio of 0% or more to 30% or less (2) A solution cooled and maintained at a temperature equal to or higher than a solidification point and lower than 15° C. (3) A solution that contains a salt with a concentration of 1 mol/L or more and a saturation concentration or less and is cooled and maintained to a temperature equal to or higher than a solidification point and lower than 25° C.

Abstract: An image processing apparatus includes an extractor and an object identifier. The extractor is configured to extract a feature quantity included in a captured image. The object identifier is configured to perform identification of an object on the basis of the feature quantity. The extractor is configured to extract the feature quantity by performing, on the captured image, a convolution calculation multiple times using a filter including multiple filter values that are two-dimensionally arranged. The multiple filter values are initially set at values that are line-symmetric with respect to an axis of symmetry along a predetermined direction. Augmentation batch data of learning data to be used in an update process of the filter by machine learning is configured to include any unflipped image extracted and a flipped image as paired images, the flipped image resulting from applying image-flipping to the unflipped image with respect to the axis of symmetry.

Abstract: A double-stranded DNA to be analyzed is analyzed without subjecting it to a modification treatment. An adapter molecule to be bound to the double-stranded DNA to be analyzed has a double-stranded nucleic acid region having base sequences complementary to each other, a pair of single-stranded nucleic acid regions having base sequences non-complementary to each other, and a block molecule placed in one of the single-stranded nucleic acid regions.