Abstract: A lead member includes a lead conductor having a first main surface and a second main surface opposite to the first main surface. The lead member includes a resin portion that covers the first main surface, the second main surface, and two side surfaces that are between both ends of the lead conductor, while exposing the both ends of the lead conductor in a first direction. The lead conductor includes a metal substrate and a surface treatment layer formed on at least a portion of a surface of the metal substrate, the surface treatment layer including chromium, oxygen, and fluorine. A moisture content of a portion of the surface treatment layer exposed from the resin portion, as measured by coulometric Karl Fischer titration at a vaporization temperature of 220° C., is 5.0 ?g/cm2 or less.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An automatic shift manual transmission equipped with a forward shifter for forward stage shifting, a reverse shifter for reverse stage shifting, an actuator rod carrying the forward shifter and the reverse shifter , and an actuator to operate the actuator rod according to shift operations of a shift lever, wherein a shifter length of the reverse shifter is substantially the same as the that of the forward shifter, and a reverse stage shift stroke is greater than a forward stage shift stroke by the difference in an operating measurement of the actuator rod.

Abstract: The object of the invention is to provide an automatic shift type manual transmission in which structural complications can be avoided and downsizing can be attained. An automatic shift type manual transmission is provided in the invention. The automatic shift type manual transmission equipped with a forward shifter to perform forward stage shifting, a reverse shifter 4 to perform reverse stage shifting, an actuator rod 3 carrying the forward shifter and the reverse shifter 4, and an actuator to operate the actuator rod according to the shift operation of the shift lever, wherein the shifter length of the reverse shifter is set to be substantially the same as the that of the forward shifter, and the reverse stage shift stroke measurement is set to be comparatively larger than the forward stage shift stroke measurement by the difference in the operating measurement of the actuator rod.

Abstract: In a pulley arrangement of a belt-type continuously variable transmission, a ring member (6) integrated with a first cylinder member (3) is coupled to a second cylinder member (5) using splines (6d and 5c) to limit mutual movements of the first and second cylinder members and using snap ring (7) to limit the axial displacement therebetween in peripheral directions of the respective first and second cylinder members. The first cylinder member is slidably contacted on an outer peripheral surface of a hollow cylindrical portion of a second conical pulley component. The second cylinder member is fixed onto an outer peripheral surface of a shaft portion of a first conical pulley component.

Abstract: In a pulley working fluid (oil) passage arrangement for a belt-type continuously variable transmission having a V belt wound about a letter V-shaped groove formed with mutually opposing oblique surfaces of movable and stationary sheaves and a working fluid pressure cylinder chamber to which a working fluid pressure is supplied so as to move the movable sheave toward or away from the stationary sheave, thus a gear shift being varied, a first working fluid passage communicated with an axle chamber working fluid passage is extended in an axial direction of the axle member at an opposing surface thereof against the axle member and the movable sheave and a second working fluid passage having one end communicated with the first working fluid passage and the other end opened to a working fluid pressure cylinder chamber is extended along a radial direction of the axle member.