Abstract: A respirable aqueous pharmaceutical composition comprising a neutralizing affinity binder for a virus binding to angiotensin-converting enzyme 2 (ACE2), a buffer, and a solubilizer.

Abstract: In the invention is provided a polypeptide comprising at least 75 amino acids and having an amino acid sequence having at least 90%, such as at least 95%, 96%, 97, 98%, or 99%, such as 100% sequence identity (% SI) with human Angiotensin-converting enzyme 2 (ACE2) (SEQ ID NO 1), for use in the treatment of COVID19, SARS, or MERS, characterized in that the polypeptide is administered pulmonary and/or nasally. Further is provided the polypeptide for use in reducing the number of active virus particles being exhaled by a treated subject infected by SARS-CoV-2, SARS-CoV, or Mers-CoV. Also a dry powder or an aerosol comprising the polypeptide.

Abstract: A method of determining the specific binding of ligand reversibly binding to a binding site in a sample using displacement competitive inhibition. The method comprising incubating the ligand (unlabeled) in the absence of a labeled ligand on a first tissue specimen, incubating the ligand (unlabeled) in the presence of a labeled ligand on a second tissue specimen, the first and the second tissue specimens being adjacent sections of specimen. MALDI imaging mass spectrometry is used to subsequently visualizing bound ligand localization, using in the first and second tissue specimen, respectively.

Abstract: The invention discloses a method for determining the molar ratio between wild type (WT) BRAF protein and protein variants thereof in a biological sample, comprising the steps of: a) Digesting said sample by using a serine proteinase which specifically cleaves peptide bonds C-terminal to glutamic acid residues or peptide bonds C-terminal to glutamic or aspartic acid residues, to obtain a composition comprising a peptide fragment resulting from digestion of the peptides by the proteinase, wherein the mass of said fragment differs between said wild type (WT) B-raf protein and one said BRAF protein variant. b) Quantitatively assaying the molar amount of the peptide fragment resulting from digestion of wild type (WT) B-raf protein and the molar amount of the peptide fragment resulting from digestion of variants of the wild type (WT) B-raf protein using a mass spectrometry technique.

Abstract: A method of determining the specific binding of ligand reversibly binding to a binding site in a sample using displacement competitive inhibition. The method comprising incubating the ligand (unlabeled) in the absence of a labeled ligand on a first tissue specimen, incubating the ligand (unlabeled) in the presence of a labeled ligand on a second tissue specimen, the first and the second tissue specimens being adjacent sections of specimen. MALDI imaging mass spectrometry is used to subsequently visualizing bound ligand localization, using in the first and second tissue specimen, respectively.

Abstract: A simply structured and smoothly operable latch device of a door in which a latch can be infallibly released by operating a handle from any of upper, lower, right, and left sides. The handle (1) having operation parts (1e) at the upper, lower, left, and right inner edges of the front opening part thereof is received in a handle receiving part (14) formed in a door (3) and having an opening in its front surface. The handle (1) can be moved to a non-operating position where the rear surface of the handle abuts on the rear end surface of the handle receiving part (14) or to an operating position where the handle (1) is tilted so that one of the upper and lower edges or one of the left and right edges is nearer to the person operating the handle (1) than the other.

Abstract: A timepiece display plate, while obtaining reflection light having metal texture, allows partial light as a transmissive light to transmit to a solar cell and easily adapt to various types of dial plates. A timepiece display plate (150) for a timepiece (200) having a plate-like solar cell (130), includes a light transmissive dial plate (151) and a brightness improving film (brightness improving plate) separately disposed between the light transmissive dial plate (151) and the solar cell (130).

Abstract: A simply structured and smoothly operable latch device of a door in which a latch can be infallibly released by operating a handle from any of upper, lower, right, and left sides. The handle (1) having operation parts (1e) at the upper, lower, left, and right inner edges of the front opening part thereof is received in a handle receiving part (14) formed in a door (3) and having an opening in its front surface. The handle (1) can be moved to a non-operating position where the rear surface of the handle abuts on the rear end surface of the handle receiving part (14) or to an operating position where the handle (1) is tilted so that one of the upper and lower edges or one of the left and right edges is nearer to the person operating the handle (1) than the other.

Abstract: The invention provides a composite from which concrete featuring a sufficiently high heat resistance can be produced, as well as a high-safety sealed concrete cask having no opening (shielding defect) to offer high shielding performance that can prevent corrosion of an internal canister and release of radioactive material to the exterior. A concrete cask of the invention includes a cask body having a bottom but no lid in itself, and a lid which can open and close off a top opening of the cask body. Both the cask body and the lid are made of concrete manufactured by using a composite including Portland cement or blended cement containing Portland cement, which is mixed with water in such a manner that the content of calcium hydroxide falls in a range of 15% to 60% by mass after hardening through hydration reaction. Metallic heat-transfer fins are embedded in the cask body.

Abstract: It is an object of the present invention to obtain a containment concrete cask which has heat removal capacity maintained at the conventional level or beyond it and which prevents radiation from leaking to the outside. In a concrete cask, a shielding body composed of concrete and heat transfer fins made from metal are provided between an inner shell and an outer shell made from metal, and an accommodation portion for accommodating a radioactive substance is provided inside the inner shell. The accommodation portion has a containment structure to be insulated from the outside of the cask. In the heat transfer fins, the portions thereof at the outer shellside are provided in contact with the outer shell and the portions thereof at the inner shell side are cut so as to form a separation portion with respect to the inner shell.

Abstract: It is an object of the present invention to obtain a containment concrete cask which has heat removal capacity maintained at the conventional level or beyond it and which prevents radiation from leaking to the outside. In a concrete cask, a shielding body composed of concrete and heat transfer fins made from metal are provided between an inner shell and an outer shell made from metal, and an accommodation portion for accommodating a radioactive substance is provided inside the inner shell. The accommodation portion has a containment structure to be insulated from the outside of the cask. In the heat transfer fins, the portions thereof at the outer shellside are provided in contact with the outer shell and the portions thereof at the inner shell side are cut so as to form a separation portion with respect to the inner shell.

Abstract: The invention provides a composite from which concrete featuring a sufficiently high heat resistance can be produced, as well as a high-safety sealed concrete cask having no opening (shielding defect) to offer high shielding performance that can prevent corrosion of an internal canister and release of radioactive material to the exterior. A concrete cask of the invention includes a cask body having a bottom but no lid in itself, and a lid which can open and close off a top opening of the cask body. Both the cask body and the lid are made of concrete manufactured by using a composite including Portland cement or blended cement containing Portland cement, which is mixed with water in such a manner that the content of calcium hydroxide falls in a range of 15% to 60% by mass after hardening through hydration reaction. Metallic heat-transfer fins are embedded in the cask body.