Abstract: An antibody-drug conjugate represented by formula (I): (where Ab is an antibody, X is a group represented by formula (X-1), formula (X-2) or formula (X-3): (where at the left represents the binding site with NH and at the right represents the binding side with D), D is a group represented by formula (D-1) or formula (D-2): (where represents the binding site with X), and n is in the range of about 1 to about 8).

Abstract: To avoid prolonged operation time at construction sites, an attachment includes an input shaft rotatable about a first rotation axis to receive power input from a power tool, a tip socket including a recess having a socket opening, a housing having a housing opening to receive a workpiece and supporting the tip socket in a rotatable manner, a power transmission that transmits, to the tip socket, power input into the input shaft, and a front aligner that stops rotation of the tip socket with the socket opening being aligned with the housing opening.

Abstract: A manual valve device including: a plurality of air bags provided inside a vehicle seat; a valve main body including a plurality of flow passages communicating with the plurality of air bags, respectively; a plurality of valve bodies movable inside the valve main body so as to open and close the plurality of flow passages, respectively; a plurality of valve shafts coupled to the plurality of valve bodies, respectively, and configured to be manually operated to move the plurality of valve bodies in a stroke; and an operation lever configured to press any one of the plurality of valve shafts or any combination of the plurality of valve shafts in an axial direction, in which the operation lever includes an adjustment mechanism configured to adjust an air flow rate per unit time flowing in the plurality of flow passages by changing a stroke amount in the axial direction.

Abstract: A tire state estimating device includes an electronic control unit. The electronic control unit is configured to acquire generated force of a tire. The electronic control unit is configured to acquire a friction coefficient between the tire and a road surface. The electronic control unit is configured to derive a grip margin of the tire. The electronic control unit is configured to estimate a contact length of the tire in an uncontrolled drive state. The electronic control unit is configured to estimate a cornering power of the tire, based on the contact length of the tire that is estimated and the generated force of the tire that is acquired.

Abstract: An upright includes an axle hub, a hub carrier, and a hub tilt detector configured to detect a tilt of the axle hub with respect to the hub carrier. The hub carrier includes a hub support that supports the axle hub, a carrier body which holds the hub support and to which the sensor of the hub tilt detector is fixed, and a deformation member interposed between the hub support and the carrier body and made of a material having a lower Young's modulus than the carrier body.

Abstract: An air supply and exhaust device including: a distributor configured to supply air by supplying air pressure from a pump sequentially to each of a plurality of air cells and exhaust air by supplying atmospheric pressure to the air cell to which air has been supplied; and a control circuit configured to cause the pump and the distributor to operate simultaneously during air supply and exhaust operation to the air cells, and stop the pump from operating and then stop the distributor from operating after a predetermined time has passed when the air supply and exhaust operation to the air cells is stopped, wherein the predetermined time is set to be longer than a time for the distributor to switch from a state of supplying air to one of the air cells to a state of exhausting air from the one of the air cells.

Abstract: A hub unit that is to be installed on a vehicle is provided with: an outer ring having, on the inner circumferential surface, a first outer raceway surface and a second outer raceway surface that is disposed to the outside of the first outer raceway surface in the vehicle width direction when the hub unit is installed on the vehicle; an inner shaft that is disposed on the inside of the outer ring concentrically with the outer ring and on which a wheel is installed on the outer end in the vehicle width direction; and an inner ring that is press-fitted to the inner shaft on the inner end in the vehicle width direction.

Abstract: A manual valve device including: a plurality of air bags provided inside a vehicle seat; a valve main body including a plurality of flow passages communicating with the plurality of air bags, respectively; a plurality of valve bodies movable inside the valve main body so as to open and close the plurality of flow passages, respectively; a plurality of valve shafts coupled to the plurality of valve bodies, respectively, and configured to be manually operated to move the plurality of valve bodies in a stroke; and an operation lever configured to press any one of the plurality of valve shafts or any combination of the plurality of valve shafts in an axial direction, in which the operation lever includes an adjustment mechanism configured to adjust an air flow rate per unit time flowing in the plurality of flow passages by changing a stroke amount in the axial direction.

Abstract: Provided is a control device for a hybrid vehicle including a controller that performs a control of the hybrid vehicle including an engine and an electric motor that serve as driving sources, a transmission, and first and second clutches. The first clutch is provided between the engine and the transmission. The second clutch is provided between the transmission and driving wheels. The controller includes first and second control units. The first control unit performs a control, in a motor traveling mode, to bring the first clutch to a disengaged state. The motor traveling mode includes traveling solely with the electric motor being driven. The second control unit performs a control, in the motor traveling mode, to bring the second clutch to a mildly engaged state in which input, from the driving-wheel side, of torque larger than driving torque causes the second clutch to slide.

Abstract: A wheel bearing apparatus includes an outer ring, an inner shaft member, rolling elements, a cage, and a sealing device. The sealing device includes an annular slinger and a sealing member. The slinger has a first inclined surface provided on a radially outer side and on a side facing the sealing member such that a diameter of the first inclined surface increases toward a first side in an axial direction. The sealing member has a second inclined surface provided on the radially outer side and on a side facing the slinger such that a diameter of the second inclined surface increases toward a second side in the axial direction. The second inclined surface intersects with a virtual extension surface extending radially outwardly along the first inclined surface, and the second inclined surface is continuous with an inner peripheral surface of the radially outer portion.

Abstract: A hub unit that is to be installed on a vehicle is provided with: an outer ring having, on the inner circumferential surface, a first outer raceway surface and a second outer raceway surface that is disposed to the outside of the first outer raceway surface in the vehicle width direction when the hub unit is installed on the vehicle; an inner shaft that is disposed on the inside of the outer ring concentrically with the outer ring and on which a wheel is installed on the outer end in the vehicle width direction; and an inner ring that is press-fitted to the inner shaft on the inner end in the vehicle width direction.

Abstract: A wheel bearing apparatus includes an outer ring, an inner shaft member, rolling elements, a cage, and a sealing device. The sealing device includes an annular slinger and a sealing member. The slinger has a first inclined surface provided on a radially outer side and on a side facing the sealing member such that a diameter of the first inclined surface increases toward a first side in an axial direction. The sealing member has a second inclined surface provided on the radially outer side and on a side facing the slinger such that a diameter of the second inclined surface increases toward a second side in the axial direction. The second inclined surface intersects with a virtual extension surface extending radially outwardly along the first inclined surface, and the second inclined surface is continuous with an inner peripheral surface of the radially outer portion.

Abstract: A hub unit includes an outer ring, an inner shaft, rolling elements and a sealing device. The outer ring includes an outer ring body and an outer ring flange. The inner shaft includes an inner shaft body and an inner shaft flange. The outer ring body includes a first portion and a second portion. The first portion is an end part on the outer side of the outer ring body. The second portion is a part of the outer ring body between the first portion and the outer ring flange. The second portion includes an upper build-up portion. The upper build-up portion is formed in an upper part of the second portion and a thickness of the build-up portion is larger than thicknesses of side parts of the second portion. An upper end of the upper build-up portion is higher than an upper end of the first portion.

Abstract: To prevent an increase of the number of kinds of components required for offset arrangement, an increase in risk of assembly error and extra time and effort for parts management, in a connector including mutually facing terminal members with contacting portions being offset in the insertion direction. Mutually facing terminal members 20 are formed on components identical in shape. The mutually facing terminal members 20 are secured to a connector housing 12 while being offset in an insertion direction of a double-sided card edge 102 inserted into a receptacle compartment 14 of the connector housing 12.

Abstract: An air supply and exhaust device including: a distributor configured to supply air by supplying air pressure from a pump sequentially to each of a plurality of air cells and exhaust air by supplying atmospheric pressure to the air cell to which air has been supplied; and a control circuit configured to cause the pump and the distributor to operate simultaneously during air supply and exhaust operation to the air cells, and stop the pump from operating and then stop the distributor from operating after a predetermined time has passed when the air supply and exhaust operation to the air cells is stopped, wherein the predetermined time is set to be longer than a time for the distributor to switch from a state of supplying air to one of the air cells to a state of exhausting air from the one of the air cells.

Abstract: A rolling device for a vehicle includes an inner raceway member including first and second inner raceways; an outer raceway member including first and second outer raceways; first rolling elements disposed rollably between the first inner raceway and the first outer raceway and second rolling elements disposed rollably between the second inner raceway and the second outer raceway; and grease disposed on raceway surfaces of the first inner raceway, the first outer raceway, the second inner raceway, and the second outer raceway and rolling surfaces of the first rolling elements and the second rolling elements. The grease includes a base oil, a thickener, and additives. The grease includes a synthetic oil as the base oil. A kinematic viscosity of the base oil at 40° C. is 20 mm2/s to 50 mm2/s. The additives include a phosphorus compound, a calcium compound, and a hydrocarbon wax.

Abstract: An electric pump includes a transmission unit that transmits rotational drive of a motor unit, a pump unit, and a rotary valve unit. The pump unit expands and contracts a pump chamber to draw in a fluid from an inlet and discharge the fluid from an outlet. The rotary valve unit includes a valve body and a valve cover. The valve body is rotated by the rotational drive force transmitted by the transmission unit. The valve cover includes a valve-side inlet that draws in a fluid and a plurality of fluid outlets that discharges the fluid to the exterior. The rotary valve unit is configured to switch the fluid outlets that come into communication with the inlet in accordance with rotational drive of the valve body. The valve body is intermittently driven by an intermittent drive mechanism that converts continuous drive corresponding to the rotational drive force into intermittent drive.