Abstract: The compositions and methods described herein are directed to treating solid tumors using CAR T therapy and/or antibodies targeting GCC. The compositions include CAR comprising an extracellular domain that binds GCC.

Abstract: The present disclosure describes compositions and methods for treating cancer. Embodiments relate to a cell modified to express one or more molecules at a level that is higher or lower than the level of the one or more molecules expressed by a cell that has not been modified to express the one or more molecules, wherein the one or more molecules comprise Cavin3, ZBED2, and MYC.

Abstract: An optical spectrometer uses broadband radiation detectors to measure thermal radiation generated by the varied heating of an object without complex mechanical mechanisms, narrowband filters, or the like. The received thermal radiation is used to deduce spectral qualities of either the thermal radiation emitter or a second object reflecting or transmitting this thermal radiation.

Abstract: An optical spectrometer uses broadband radiation detectors to measure thermal radiation generated by the varied heating of an object without complex mechanical mechanisms, narrowband filters, or the like. The received thermal radiation is used to deduce spectral qualities of either the thermal radiation emitter or a second object reflecting or transmitting this thermal radiation.

Abstract: A metallic quantum well may be formed by interposing a layer of metallic well material two layers of barrier material. Two or more metallic quantum wells may be combined to form a coupled metallic quantum well. The absorption spectrum and the emission spectrum of the coupled metallic quantum well may be tuned by at least adjusting the dimensions of the individual metallic quantum wells and/or the materials forming the metallic quantum wells. The metallic quantum well and/or the coupled metallic quantum well may exhibit sufficient nonlinearity even at a miniaturized scale. As such, the metallic quantum well and/or coupled metallic quantum well may be used for a variety of on-chip applications including, for example, as part of an on-chip pulse limiter, an on-chip super-continuum generator, and/or the like.

Abstract: A metallic quantum well may be formed by interposing a layer of metallic well material two layers of barrier material. Two or more metallic quantum wells may be combined to form a coupled metallic quantum well. The absorption spectrum and the emission spectrum of the coupled metallic quantum well may be tuned by at least adjusting the dimensions of the individual metallic quantum wells and/or the materials forming the metallic quantum wells. The metallic quantum well and/or the coupled metallic quantum well may exhibit sufficient nonlinearity even at a miniaturized scale. As such, the metallic quantum well and/or coupled metallic quantum well may be used for a variety of on-chip applications including, for example, as part of an on-chip pulse limiter, an on-chip super-continuum generator, and/or the like.