Patents by Inventor Yuzo Toda
Yuzo Toda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230241257Abstract: It is an object of the present invention to provide a novel halogenated biotin-modified dimer capable of performing imaging diagnosis or treatment. According to the present invention, a compound represented by the following formula (1) or a salt thereof is provided: wherein L1 represents a trivalent linking group, L2 represents a divalent linking group, Hal represents a halogen, p represents an integer of 1 to 5, and q, r, s, and t each independently represent an integer of 1 to 8.Type: ApplicationFiled: April 13, 2021Publication date: August 3, 2023Applicants: THE UNIVERSITY OF TOKYO, SAVID THERAPEUTICS INC., FUKUSHIMA MEDICAL UNIVERSITYInventors: Motomu KANAI, Kenzo YAMATSUGU, Toshifumi TATSUMI, Tatsuhiko KODAMA, Akira SUGIYAMA, Masanobu TSUKAGOSHI, Yuzo TODA, Kohshin WASHIYAMA, Kazuhiro TAKAHASHI, Songji ZHAO, Naoyuki UKON, Miho SUZUKI
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Publication number: 20230125454Abstract: Objects of the present invention are to provide a novel phthalocyanine dye for use in photoimmunotherapy, and a method for producing the same, and to provide a conjugate of the above-described phthalocyanine dye and an antibody or a peptide. According to the present invention, a compound represented by the following formula (1) or a salt thereof is provided: wherein X represents a substituent having a hydrophilic group at the terminus thereof; L3, L4, L5, and L6 each independently represent a divalent linking group; Y represents a group capable of binding to an antibody or a peptide; R3 represents a substituent, such as an alkyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms, a halogen atom, —SR11, —SOR12, an aryl group containing 6 to 10 carbon atoms, —N(R13)(R14), or —NO2, wherein when a plurality of R3s are present, the plurality of R3s may be identical to or different from one another; and s represents an integer of 0 to 4.Type: ApplicationFiled: February 4, 2021Publication date: April 27, 2023Applicants: THE UNIVERSITY OF TOKYO, SAVID THERAPEUTICS INC.Inventors: Motomu KANAI, Kenzo YAMATSUGU, Toshifumi TATSUMI, Kazuki TAKAHASHI, Tatsuhiko KODAMA, Akira SUGIYAMA, Masanobu TSUKAGOSHI, Yuzo TODA
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Publication number: 20230106135Abstract: [Object] It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy. [Means for Solution] A compound represented by the following formula (1) or a salt thereof: wherein X represents a substituent having a hydrophilic group, a cationic group or an amino group at the terminus thereof, or —OH, and other groups have the meanings as defined in the description.Type: ApplicationFiled: April 22, 2021Publication date: April 6, 2023Applicants: THE UNIVERSITY OF TOKYO, SAVID THERAPEUTICS INC.Inventors: Motomu KANAI, Kenzo YAMATSUGU, Toshifumi TATSUMI, Kazuki TAKAHASHI, Tatsuhiko KODAMA, Akira SUGIYAMA, Takefumi YAMASHITA, Masanobu TSUKAGOSHI, Yuzo TODA, Junji NISHIGAKI
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Publication number: 20220348681Abstract: [Object] To provide a fusion protein of an antibody that recognizes cancer cells and a mutant streptavidin, which is for use in the treatment or diagnosis of cancer. [Means for Solution] A fusion protein comprising a protein-recognizing substance and the amino acid sequence as set forth in SEQ ID NO: 19 that is fused with the protein-recognizing substance.Type: ApplicationFiled: April 22, 2021Publication date: November 3, 2022Applicants: THE UNIVERSITY OF TOKYO, SAVID THERAPEUTICS INC.Inventors: Toshiya TANAKA, Tatsuhiko KODAMA, Takefumi YAMASHITA, Motomu KANAI, Kenzo YAMATSUGU, Toshifumi TATSUMI, Takeshi KAWAMURA, Akira SUGIYAMA, Masanobu TSUKAGOSHI, Yuzo TODA, Junji NISHIGAKI
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Patent number: 8138139Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: July 17, 2009Date of Patent: March 20, 2012Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Patent number: 8080515Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: June 30, 2009Date of Patent: December 20, 2011Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Publication number: 20100222264Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines arc prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: ApplicationFiled: July 17, 2009Publication date: September 2, 2010Inventors: JAN BASTIAAN BOUWSTRA, ANDRIES JOHANNES JOZEF VAN ES, YUZO TODA
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Publication number: 20100069512Abstract: The invention provides oil-in-water emulsions comprising recombinant collagen-like polymer in an amount sufficient to act as stabiliser of the emulsion. The polymer is especially a polypeptide which is free of helix structure, has an isoelectric point at least 0.5 pH units removed from the pH of the oil-in-water emulsion. Furthermore, bipolar recombinant collagen-like polymers are provided for use in oil-in-water emulsions. The bipolar polymers are polar at one end as a result of a relative abundance of polar amino acids, and apolar at the other end as a result of a relative abundance of apolar amino acids.Type: ApplicationFiled: May 21, 2007Publication date: March 18, 2010Applicant: FUJI FILM MANUFACTURING EUROPE B.V.Inventors: Joseph Hubertus OLIJVE, Jan Bastiaan BOUWSTRA, Frederik Anton WOLF DE, Marc Willem Theodoor WERTEN, Hendrik Wouter WISSELINK, Richele Deodata WIND, Tanja Jacoba BOSCH VAN DEN, Yuzo TODA
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Patent number: 7671016Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: June 28, 2007Date of Patent: March 2, 2010Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Patent number: 7670839Abstract: The invention relates to a support for culturing cells, in particular to microcarriers coated with gelatine or gelatine-like proteins. Such microcarriers serve as support for culturing anchorage dependent cells. In particular the invention relates to a process for the preparation of a cell culture support comprising the step of coating a microcarrier bead with gelatine or gelatine-like protein, said gelatine or gelatine-like protein having a molecular weight of about 40 kDa to about 200 kDa.Type: GrantFiled: December 23, 2003Date of Patent: March 2, 2010Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Publication number: 20100048477Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: ApplicationFiled: June 30, 2009Publication date: February 25, 2010Inventors: Jan Bastiaan BOUWSTRA, Andries Johannes Jozef VAN ES, Yuzo TODA
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Patent number: 7645737Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: June 28, 2007Date of Patent: January 12, 2010Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Patent number: 7598347Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: June 28, 2007Date of Patent: October 6, 2009Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Patent number: 7579314Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: June 28, 2007Date of Patent: August 25, 2009Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Publication number: 20090182063Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: ApplicationFiled: June 28, 2007Publication date: July 16, 2009Applicant: FUJIFILM MANUFACTURING EUROPE B.V.Inventors: Jan Bastiaan BOUWSTRA, Andries Johannes Jozef VAN ES, Yuzo TODA
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Patent number: 7560427Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: GrantFiled: June 28, 2007Date of Patent: July 14, 2009Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Patent number: 7517954Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor dependant cell types.Type: GrantFiled: March 26, 2004Date of Patent: April 14, 2009Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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Patent number: 7459431Abstract: The invention relates to compositions suitable for plasma substitution comprising as a plasma expander a recombinant gelatin-like protein. Characteristic is that the gelatin-like protein essentially is free of hydroxyproline. This absence of hydroxyproline prevents the composition from gelling and thus allows the use of high-molecular weight proteins in order to establish a suitable colloid osmotic pressure. Specific advantage of the gelatin-like proteins is that these avoid the risk of anaphylactic shock that exists in conjunction with the use of commercially available preparations.Type: GrantFiled: March 6, 2002Date of Patent: December 2, 2008Assignee: Fuji Film Manufacturing Europe B.V.Inventors: Jan Bastiaan Bouwstra, Yuzo Toda
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Publication number: 20080274957Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: ApplicationFiled: June 28, 2007Publication date: November 6, 2008Applicant: FUJIFILM MANUFACTURING EUROPE B.V.Inventors: Jan Bastiaan BOUWSTRA, Andries Johannes Jozef VAN ES, Yuzo TODA
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Publication number: 20080167446Abstract: The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types.Type: ApplicationFiled: June 28, 2007Publication date: July 10, 2008Applicant: FUJIFILM MANUFACTURING EUROPE B.V.Inventors: Jan Bastiaan BOUWSTRA, Andries Johannes Jozef VAN ES, Yuzo TODA