Patents by Inventor Yuzuru Morino
Yuzuru Morino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9637435Abstract: Disclosed is a method for producing a hexafluoroisopropanol, including the steps of (a) purifying a mixture containing hexafluoroacetone and at least 1,1,1-trifluoro-2,2-dichloroethane as an impurity, thereby obtaining a purified hexafluoroacetone containing 120 ppm or lower of the 1,1,1-trifluoro-2,2-dichloroethane; and (b) bringing hydrogen (H2) into contact with the purified hexafluoroacetone in the presence of a catalyst, thereby hydrogenating the hexafluoroacetone into the hexafluoroisopropanol. It is possible by this method to produce the hexafluoroisopropanol with a short reaction time and a high conversion. Therefore, it is possible to particularly advantageously produce fluoromethyl hexafluoroisopropyl ether (sevoflurane) by using the hexafluoroisopropanol produced by the method.Type: GrantFiled: November 29, 2016Date of Patent: May 2, 2017Assignee: Central Glass Company, LimitedInventors: Yuzuru Morino, Shigeru Fujii, Toshihiro Nakamichi, Shinya Akiba, Masaaki Takeda, Masaki Fujiwara
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Patent number: 8748653Abstract: Disclosed is a purification method of reducing and removing fluoride ions contained in an optically active ?-fluorocarboxylic acid ester represented by formula [1] [in the formula, R1 represents a C1-6 alkyl group, R2 represents a C1-4 alkyl group, and * represents an asymmetric carbon], the purification method of the optically active ?-fluorocarboxylic acid ester being characterized by that a distillation is conducted in the presence of an organic base. By this method, it is possible to greatly reduce the concentration of fluoride ion traces contained in the optically active ?-fluorocarboxylic acid ester by a relatively easy operation. Of the organic base, a tertiary amine is preferable, and above all tri-n-butylamine is particularly preferable.Type: GrantFiled: August 5, 2008Date of Patent: June 10, 2014Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Hideyuki Tsuruta, Yuzuru Morino, Mikihiro Takahashi
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Patent number: 8283489Abstract: An optically active ?-fluorocarboxylate is produced by reacting an optically active ?-hydroxycarboxylate with sulfuryl fluoride (SO2F2), trifluoromethanesulfonyl fluoride (CF3SO2F) or nonafluorobutanesulfonyl fluoride (C4F9SO2F) in the presence of organic base and in the absence of reaction solvent. More preferably, a distillation purification is conducted after adding acid to the reaction-terminated liquid. With this, it is possible to produce an optically active ?-fluorocarboxylate of a still higher purity. It is possible by this process to advantageously produce an optically active ?-fluorocarboxylate on a large-amount scale.Type: GrantFiled: January 8, 2008Date of Patent: October 9, 2012Assignee: Central Glass Company, LimitedInventors: Akihiro Ishii, Hideyuki Tsuruta, Yuzuru Morino, Mikihiro Takahashi
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Publication number: 20110021809Abstract: Disclosed is a purification method of reducing and removing fluoride ions contained in an optically active ?-fluorocarboxylic acid ester represented by formula [1] [in the formula, R1 represents a C1-6 alkyl group, R2 represents a C1-4 alkyl group, and * represents an asymmetric carbon], the purification method of the optically active ?-fluorocarboxylic acid ester being characterized by that a distillation is conducted in the presence of an organic base. By this method, it is possible to greatly reduce the concentration of fluoride ion traces contained in the optically active ?-fluorocarboxylic acid ester by a relatively easy operation. Of the organic base, a tertiary amine is preferable, and above all tri-n-butylamine is particularly preferable.Type: ApplicationFiled: August 5, 2008Publication date: January 27, 2011Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Akihiro Ishii, Hideyuki Tsuruta, Yuzuru Morino, Mikihiro Takahashi
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Publication number: 20100087673Abstract: An optically active ?-fluorocarboxylate is produced by reacting an optically active ?-hydroxycarboxylate with sulfuryl fluoride (SO2F2), trifluoromethanesulfonyl fluoride (CF3SO2F) or nonafluorobutanesulfonyl fluoride (C4F9SO2F) in the presence of organic base and in the absence of reaction solvent. More preferably, a distillation purification is conducted after adding acid to the reaction-terminated liquid. With this, it is possible to produce an optically active ?-fluorocarboxylate of a still higher purity. It is possible by this process to advantageously produce an optically active ?-fluorocarboxylate on a large-amount scale.Type: ApplicationFiled: January 8, 2008Publication date: April 8, 2010Applicant: CENTRAL GLASS COMPANY, LTDInventors: Akihiro Ishii, Hideyuki Tsuruta, Yuzuru Morino, Mikihiro Takahashi
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Patent number: 6706905Abstract: An aromatic compound represented by the general formula Ar1X is reacted with a palladium compound and a phosphine derivative, in the presence of a first basic substance, thereby producing a palladium-complex compound represented by the general formula Ar1—PdL2X. This palladium-complex compound is reacted with a benzoic acid represented by the general formula Ar2—COOH, in the presence of a second basic substance, thereby producing another palladium-complex compound represented by the following general formula. The above palladium-complex compounds are useful as catalysts and can be produced easily by the above reactions. In the above general formulas, Ar1 is an aryl group; and X is a halogen that is fluorine, chlorine, bromine or iodine, trifluoromethanesulfonate group, an alkylsulfonate group having a carbon atom number of 1-4, or a substituted or unsubstituted arylsulfonate group; each L is independently a phosphine ligand; and Ar2 is an aryl group.Type: GrantFiled: December 10, 1999Date of Patent: March 16, 2004Inventors: Takashi Kume, Satoru Narizuka, Makoto Koide, Koichi Mikami, Manabu Hatano, Masahiro Terada, Michio Ishida, Yuzuru Morino
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Publication number: 20020111482Abstract: An aromatic compound represented by the general formula Ar1X is reacted with a palladium compound and a phosphine derivative, in the presence of a first basic substance, thereby producing a palladium-complex compound represented by the general formula Ar1—PdL2X. This palladium-complex compound is reacted with a benzoic acid represented by the general formula Ar2—COOH, in the presence of a second basic substance, thereby producing another palladium-complex compound represented by the following general formula.Type: ApplicationFiled: April 5, 2002Publication date: August 15, 2002Applicant: Central Glass Company, LimitedInventors: Takashi Kume, Satoru Narizuka, Makoto Koide, Michio Ishida, Yuzuru Morino
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Patent number: 6326517Abstract: A method of producing benzamides represented by the following general formula (1): where R is trifluoromethyl group, trifluoromethyloxy group, halogen (fluorine, chlorine, bromine or iodine), nitro group, acetyl group, cyano group, alkyl group having 1 to 4 carbon atoms, alkoxy group having 1 to 4 carbon atoms, or a alkoxycarbonyl group having 2 to 5 carbon atoms; and n is 0 or an integer ranging from 1 to 3.Type: GrantFiled: December 10, 1999Date of Patent: December 4, 2001Assignee: Central Glass Company, LimitedInventors: Takashi Kume, Michio Ishida, Satoru Narizuka, Yuzuru Morino, Makoto Koide
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Patent number: 6268527Abstract: The invention relates to a method for producing a benzoic acid derivative represented by the general formula (1). The method includes the step of reacting an aromatic compound represented by the general formula (2), with carbon monoxide and a hydroxy compound (i.e., water or an alcohol), in the presence of (a) a metal compound containing a metal of 8, 9 and 10 groups of periodic table, (b) a first phosphine derivative represented by the general formula (R1)2P—Q—P(R1)2, and (c) a base, It is possible to easily and efficiently produce the benzoic acid derivative by the method.Type: GrantFiled: December 2, 1999Date of Patent: July 31, 2001Assignee: Central Glass Company, LimitedInventors: Makoto Koide, Michio Ishida, Yuzuru Morino, Seiji Hasegawa, Satoru Narizuka, Takashi Kume
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Patent number: 5440047Abstract: The invention relates to a method of preparing 2-chloro-pyridinemethanol represented by the following formula (1). The method includes the steps of: (a) reacting 2-chloro-monochloromethylpyridine with an alkali metal salt of a carboxylic acid and/or a hydrate of the alkali metal salt so as to form an ester derivative; and (b) hydrolyzing the ester derivative so as to form the 2-chloro-pyridinemethanol.Type: GrantFiled: June 1, 1994Date of Patent: August 8, 1995Assignee: Central Glass Company, LimitedInventors: Yasunobu Nishimura, Akihiro Ishii, Yuzuru Morino, Yoshiyuki Kikuchi