Patents by Inventor Yves Borel

Yves Borel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
    Patent number: 7306782
    Abstract: The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hydroxylsuccinimide ester group and a maleimide group linked via a polyethylene oxide spacer; (b) removing excess heterobifunctional crosslinker; and (c) incubating the reaction product of step (b) with said second polypeptide, wherein said second polypeptide comprises at least one sulfhydryl group. Furthermore, the present invention relates to a conjugate obtainable by the method of the present invention. Also described is a pharmaceutical composition comprising the conjugate of the present invention and, optionally, a pharmaceutically acceptable carrier and/or diluent, and the use of the conjugate for the preparation of a pharmaceutical composition for preventing and/or treating an allergic disease or an autoimmune disease.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: December 11, 2007
    Assignee: Tolerogen Ltd
    Inventors: Yves Borel, Werner Schlegel, Erwin Gelfand
  • Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
    Publication number: 20030161837
    Abstract: The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hydroxylsuccinimide ester group and a maleimide group linked via a polyethylene oxide spacer; (b) removing excess heterobifunctional crosslinker; and (c) incubating the reaction product of step (b) with said second polypeptide, wherein said second polypeptide comprises at least one sulfhydryl group. Furthermore, the present invention relates to a conjugate obtainable by the method of the present invention. Also described is a pharmaceutical composition comprising the conjugate of the present invention and, optionally, a pharmaceutically acceptable carrier and/or diluent, and the use of the conjugate for the preparation of a pharmaceutical composition for preventing and/or treating an allergic disease or an autoimmune disease.
    Type: Application
    Filed: February 14, 2003
    Publication date: August 28, 2003
    Applicant: Aventis Behring GmbH
    Inventors: Yves Borel, Werner Schlegel, Erwin Gelfand
  • Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
    Patent number: 6537519
    Abstract: The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hydroxylsuccinimide ester group and a maleimide group linked via a polyethylene oxide spacer; (b) removing excess heterobifunctional crosslinker; and (c) incubating the reaction product of step (b) with said second polypeptide, wherein said second polypeptide comprises at least one sulfhydryl group. Furthermore, the present invention relates to a conjugate obtainable by the method of the present invention. Also described is a pharmaceutical composition comprising the conjugate of the present invention and, optionally, a pharmaceutically acceptable carrier and/or diluent, and the use of the conjugate for the preparation of a pharmaceutical composition for preventing and/or treating an allergic disease or an autoimmune disease.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: March 25, 2003
    Assignee: Aventis Behring GmbH
    Inventors: Yves Borel, Werner Schlegel, Erwin Gelfand
  • Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
    Publication number: 20010007755
    Abstract: The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hydroxylsuccinimide ester group and a maleimide group linked via a polyethylene oxide spacer; (b) removing excess heterobifunctional crosslinker; and (c) incubating the reaction product of step (b) with said second polypeptide, wherein said second polypeptide comprises at least one sulfhydryl group.
    Type: Application
    Filed: January 8, 2001
    Publication date: July 12, 2001
    Inventors: Yves Borel, Werner Schlegel, Erwin Gelfand
  • Oligonucleotide conjugates
    Patent number: 4650675
    Abstract: Conjugate composed of an oligonucleotide covalently bonded to a carrier.
    Type: Grant
    Filed: August 18, 1983
    Date of Patent: March 17, 1987
    Assignee: The Children's Medical Center Corporation
    Inventors: Yves Borel, B. David Stollar, Helina Borel, Paul M. Gallop