Abstract: There is provided a refrigerating assembly for temporarily storing an item at a first temperature lower than an ambient temperature. The refrigerating assembly comprises a container for receiving the item and a shell adapted for removably receiving the container therein. The container comprises a sidewall having therein defined a cavity containing an amount of a refrigerant medium having a second temperature lower than the ambient temperature for temporarily maintaining the item received in the container at the first temperature. The shell has an outer surface which is at the ambient temperature and an inner surface which has a layer of thermally insulating material mounted thereon for thermally insulating the shell from the container, thereby maintaining the outer surface at the ambient temperature. There is further provided a method for temporarily storing an item at a first temperature lower than an ambient temperature.

Abstract: There is provided a refrigerating assembly for temporarily storing an item at a first temperature lower than an ambient temperature. The refrigerating assembly comprises a container for receiving the item and a shell adapted for removably receiving the container therein. The container comprises a sidewall having therein defined a cavity containing an amount of a refrigerant medium having a second temperature lower than the ambient temperature for temporarily maintaining the item received in the container at the first temperature. The shell has an outer surface which is at the ambient temperature and an inner surface which has a layer of thermally insulating material mounted thereon for thermally insulating the shell from the container, thereby maintaining the outer surface at the ambient temperature. There is further provided a method for temporarily storing an item at a first temperature lower than an ambient temperature.

Abstract: A refrigerating assembly temporarily stores an item at a first temperature lower than an ambient temperature. A container receives the item and a shell is adapted for removably receiving the container therein. The container has a sidewall having a cavity therein containing an amount of a refrigerant medium having a second temperature lower than the ambient temperature for temporarily maintaining the item received in the container at the first temperature. The shell has an outer surface which is at the ambient temperature and an inner surface which has a layer of thermally insulating material mounted thereon for thermally insulating the shell from the container, thereby maintaining the outer surface at the ambient temperature.

Abstract: There is provided a refrigerating assembly for temporarily storing an item at a first temperature lower than an ambient temperature. The refrigerating assembly comprises a container for receiving the item and a shell adapted for removably receiving the container therein. The container comprises a sidewall having therein defined a cavity containing an amount of a refrigerant medium having a second temperature lower than the ambient temperature for temporarily maintaining the item received in the container at the first temperature. The shell has an outer surface which is at the ambient temperature and an inner surface which has a layer of thermally insulating material mounted thereon for thermally insulating the shell from the container, thereby maintaining the outer surface at the ambient temperature. There is further provided a method for temporarily storing an item at a first temperature lower than an ambient temperature.

Abstract: The present invention provides triazole derivatives according to formula (I) as ligands of G-protein coupled receptors (GPCR), which are useful for the study of and/or the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, which are mediated by GPCR.

Abstract: This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components possessing at least an activity against a matrix metalloprotease (anti-MMP). This invention also relates to a process by which a total liquid extract of shark cartilage composed of molecules having molecular weights less than about 500kDa (0-500 fraction) is purified into two well separated fractions composed of molecules having molecular weights less than about 1 kDa (0-1 fraction) and between about 1 to 500 kDa (1-500 fraction). In order to prevent the formation of aggregates, to improve the dissolution and the stability of active components, sucrose or other stabilizing agents can be added.

Abstract: This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components. Amongst the tested solvents, trimethylamine 40% (in water) was selected as a good alternative solvent to pure water, particularly in recovering an anti-proliferative activity against HUVECs.

Abstract: This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components possessing at least an activity against a matrix metalloprotease (anti-MMP). This invention also relates to a process by which a total liquid extract of shark cartilage composed of molecules having molecular weights less than about 500kDa (0-500 fraction) is purified into two well separated fractions composed of molecules having molecular weights less than about 1 kDa (0-1 fraction) and between about 1 to 500 kDa (1-500 fraction). In order to prevent the formation of aggregates, to improve the dissolution and the stability of active components, sucrose or other stabilizing agents can be added.

Abstract: This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components possessing at least an activity against a matrix metalloprotease (anti-MMP). This invention also relates to a process by which a total liquid extract of shark cartilage composed of molecules having molecular weights less than about 500 kDa (0-500 fraction) is purified into two well separated fractions composed of molecules having molecular weights less than about 1 kDa (0-1 fraction) and between about 1 to 500 kDa (1-500 fraction). In order to prevent the formation of aggregates, to improve the dissolution and the stability of active components, sucrose or other stabilizing agents can be added.