Abstract: A method of operating an internal combustion engine including at least a combustion chamber having a piston disposed therein, wherein the combustion chamber is configured to receive air, a first fuel and a second fuel to form a substantially homogeneous mixture, and wherein the piston is configured to compress said mixture so that auto-ignition of said mixture is achieved is disclosed. The method comprises varying the amount of at least one of the first fuel and the second fuel that is received by the combustion chamber to adjust the timing of auto-ignition, where the first fuel includes diesel fuel and the second fuel includes such low cetane fuels as: methanol and ethanol.