Patents by Inventor Zane Baird
Zane Baird has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240170273Abstract: A rigid hull with a flat bottom is covered on the underside by a membrane or sail that is held taut and flush during flight mode for improved aerodynamics with conventional landing gear behind it that is attached to a rail or ski with hinges such that when the landing gear is deployed, the ski presses into the membrane, approximately forming the shape of a boat hull for maritime situations and soft landing especially.Type: ApplicationFiled: December 4, 2023Publication date: May 23, 2024Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
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Patent number: 11837455Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.Type: GrantFiled: June 3, 2022Date of Patent: December 5, 2023Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Pu Wei
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Patent number: 11830717Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: GrantFiled: April 14, 2023Date of Patent: November 28, 2023Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Publication number: 20230260772Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: ApplicationFiled: April 14, 2023Publication date: August 17, 2023Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Patent number: 11631577Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: GrantFiled: July 8, 2022Date of Patent: April 18, 2023Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Publication number: 20230115304Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.Type: ApplicationFiled: December 6, 2022Publication date: April 13, 2023Inventors: Zane Baird, Robert Graham Cooks, Adam Hollerbach, Zheng Ouyang, Michael Pugia
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Patent number: 11531024Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.Type: GrantFiled: September 24, 2016Date of Patent: December 20, 2022Assignee: Purdue Research FoundationInventors: Zane Baird, Robert Graham Cooks, Adam Hollerbach, Zheng Ouyang, Michael Pugia
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Publication number: 20220359183Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: ApplicationFiled: July 8, 2022Publication date: November 10, 2022Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Patent number: 11469090Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: GrantFiled: January 14, 2021Date of Patent: October 11, 2022Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Publication number: 20220301844Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.Type: ApplicationFiled: June 3, 2022Publication date: September 22, 2022Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
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Publication number: 20220216046Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: ApplicationFiled: January 14, 2021Publication date: July 7, 2022Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Patent number: 11380534Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.Type: GrantFiled: June 8, 2020Date of Patent: July 5, 2022Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Pu Wei
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Publication number: 20210293826Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.Type: ApplicationFiled: June 9, 2021Publication date: September 23, 2021Inventors: Robert Graham Cooks, Zane Baird, Michael Pugia, Adam Hollerbach, Stephen Ayrton
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Publication number: 20210278399Abstract: The invention described herein is directed to methods of isolation and detection of target analytes in a sample. The target analytes are coupled to analyte detection particles which comprise base particles having labels and affinity agents coupled thereto by linker arms. The linker arms form bonds with the labels and target analytes and are cleavable under different label and affinity cleavable conditions. Systems and methods for preparing and using the analyte detection particles are also disclosed.Type: ApplicationFiled: March 4, 2020Publication date: September 9, 2021Applicant: Indiana Biosciences Research Institute, IncInventors: Michael Joseph Pugia, Zane Baird
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Patent number: 11061035Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.Type: GrantFiled: January 20, 2017Date of Patent: July 13, 2021Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Michael Pugia, Adam Hollerbach, Stephen Ayrton
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Patent number: 10923338Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: GrantFiled: August 7, 2020Date of Patent: February 16, 2021Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Publication number: 20200381237Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: ApplicationFiled: August 7, 2020Publication date: December 3, 2020Inventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Publication number: 20200312650Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.Type: ApplicationFiled: June 8, 2020Publication date: October 1, 2020Inventors: Robert Graham Cooks, Zane Baird, Pu Wei
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Patent number: 10777400Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.Type: GrantFiled: February 27, 2020Date of Patent: September 15, 2020Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Wen-Ping Peng
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Patent number: 10720316Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.Type: GrantFiled: August 14, 2018Date of Patent: July 21, 2020Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Pu Wei