Abstract: Disclosed are a full-automatic high-pressure spray cleaning and rust prevention device and an application method thereof. The device comprises a cleaning platform, a center rod and a swingable clamp module; the center rod is arranged on the cleaning platform, and an upper end is fixedly provided with the swingable clamp module; the swingable clamp module comprises a worm gear and worm assembly and a clamp, and the worm gear and worm assembly is capable of driving the clamp to deflect up and down; a driving mechanism arranged in a bottom portion of the cleaning platform is in driving connection with the center rod, so that the center rod is capable of driving the swingable clamp module to realize vertical lifting motion and rotary station switching; and the cleaning platform is sequentially provided with a positioning and spraying area, an air-drying area and a rust prevention area around the center rod.