Abstract: An anti-fingerprint treatment reagent has an organic polydimethlysiloxane, a solvent and an additive. A surface of a metal base material is treated by the organic polydimethlysiloxane. The surface treated with the anti-fingerprint reagent is fingerprint-resistant for being hydro-oleophobic. The coating of thanti-fingerprint treatment reagent is too thin to be seen, and will not affect the optical properties and function of the surface of the base material. The anti-fingerprint treatment reagent is inexpensive, simple in treatment process, reusable and practical. Especially, the anti-fingerprint reagent fits to avoid a product surface having pollution likes water spot, sweat, fingerprint and the like.