Abstract: It discloses a sustained release grouting material, a preparation method and an application thereof; the sustained release grouting material comprises a water swelling core and a water-soluble sustained release coating, the water swelling core is composed of bentonite, SAP and xanthan gum, which is granulated by disc granulator relying on the cohesiveness of xanthan gum; the water-soluble sustained-release coating is prepared by mixing water-soluble starch, polyvinyl alcohol, poloxamer, lubricant and plasticizer with deionized water to obtain a film-forming solution, and the film-forming solution is coated on a coating machine; the invention uses a coating machine to coat a layer of slow-release coating on the surface of the water-absorbing expansion core, and adjusts the coating thickness by controlling the mass ratio of the coating film-forming liquid to the water-absorbing expansion core particles, so as to realize the controllable water absorption onset time of the expansion core.

Abstract: A compact steel cord is provided. The cord includes a core-filament I steel wire with a diameter of d0, and four middle-layer M steel wires with a diameter of d1 and eight outer-layer O steel wires with a diameter of d2 that are twisted around the core-filament I steel wire in the same lay direction and the same lay length. Gaps L are reserved between the outer-layer O steel wires, an average width of the gaps L is not smaller than 0.02 mm, and the total size of the gaps L is larger than d0 and smaller than d1. The steel cord of a stable structure can be obtained by controlling the proportion of the sizes of all layers of monofilaments, the rubber coating performance of a tire cord can also be improved, the corrosion resistance, fatigue resistance, impact resistance and adhesion retention of a tire are improved.

Abstract: Techniques are described for training and evaluating a proximal factorization machine engine. In one or more embodiments, the engine receives a set of training data that identifies a set of actions taken by a plurality of users with respect to a plurality of items. The engine generates, for a prediction model, (a) a first set of model parameters representing relationships between features of the plurality of users and the set of actions, and (b) a second set of model parameters representing interactions between different features of the plurality of users and the plurality of items. For each respective item in a plurality of items, the engine computes a probabilistic score based on the model parameters. The engine selects and presents a subset of items based on the probabilistic scores.

Abstract: The present invention discloses a flexible connecting structure of a prefabricated component and a building main body. The flexible connecting structure comprises multiple layers of cast-in-situ building main bodies spaced up and down, a prefabricated component is connected between two adjacent cast-in-situ building main bodies, a tenon is provided at the lower end of the prefabricated component, a mortise matching the tenon is provided on the top surface of the cast-in-situ building main body, and the prefabricated component is socketed to the lower layer of cast-in-situ building main body by tenon-and-mortise cooperation; and a first flexible layer for reducing the connection rigidity between the prefabricated component and the upper layer of cast-in-situ building main body is provided at the junction between the prefabricated component and the upper layer of cast-in-situ building main body.

Abstract: The present invention discloses a flexible connecting structure of a prefabricated component and a building main body. The flexible connecting structure comprises multiple layers of cast-in-situ building main bodies spaced up and down, a prefabricated component is connected between two adjacent cast-in-situ building main bodies, a tenon is provided at the lower end of the prefabricated component, a mortise matching the tenon is provided on the top surface of the cast-in-situ building main body, and the prefabricated component is socketed to the lower layer of cast-in-situ building main body by tenon-and-mortise cooperation; and a first flexible layer for reducing the connection rigidity between the prefabricated component and the upper layer of cast-in-situ building main body is provided at the junction between the prefabricated component and the upper layer of cast-in-situ building main body.

Abstract: Techniques are described for training and evaluating a proximal factorization machine engine. In one or more embodiments, the engine receives a set of training data that identifies a set of actions taken by a plurality of users with respect to a plurality of items. The engine generates, for a prediction model, (a) a first set of model parameters representing relationships between features of the plurality of users and the set of actions, and (b) a second set of model parameters representing interactions between different features of the plurality of users and the plurality of items. For each respective item in a plurality of items, the engine computes a probabilistic score based on the model parameters. The engine selects and presents a subset of items based on the probabilistic scores.

Abstract: The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

Abstract: The invention provides a composition comprising four adenoviral vectors, each comprising a nucleic acid sequence encoding a clade A HIV Env protein, a clade B HIV Env protein, a clade C HIV Env protein, and a clade B HIV Gag-Pol fusion protein, respectively. The invention also provides a method of inducing an immune response against HIV-1 in an animal comprising administering the composition to the animal.

Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

Abstract: The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

Abstract: The invention provides a composition comprising a pharmaceutically acceptable carrier and six plasmids, each of which encodes an HIV Env, Gag, Pol, or Nef protein. The invention also provides a method of inducing an immune response in an animal using the composition.

Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single Glade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

Abstract: The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

Abstract: Modified HIV Env, Gag, Pol, or Nef DNA with improved ability to elicit antibody and CTL responses to HIV antigens have been identified as prototype immunogens for the treatment and prevention of HIV infections.

Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

Abstract: In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.