Patents by Inventor Zenon Steplewski

Zenon Steplewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies against glycolipid antigens, methods of producing these antibodies, and use therefor
    Patent number: 5182192
    Abstract: The present invention is directed to in vitro and in vivo immunodiagnosis and immunotherapy using monoclonal antibodies reactive with difucosyl blood group antigens Y-6 and B-7-2.
    Type: Grant
    Filed: August 6, 1990
    Date of Patent: January 26, 1993
    Assignee: The Wistar Institute
    Inventors: Zenon Steplewski, Hilary Koprowski, Magdalena Thurin
  • Monoclonal antibodies against lymphoma-associated antigens, hybrid cell lines producing these antibodies
    Patent number: 5169775
    Abstract: The present invention is directed to monoclonal antibodies, and hybridomas which produce them, which are preferentially reactive with canine lymphoma cells and insignificantly reactive with normal canine lymphocytes.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: December 8, 1992
    Assignee: The Wistar Institute
    Inventors: Zenon Steplewski, K. Ann Jeglum
  • Radiotherapeutic immunoconjugates labeled with iodine-125
    Patent number: 5130116
    Abstract: A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide and method of using it is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: July 14, 1992
    Assignee: Centocor, Inc.
    Inventors: David V. Woo, Zenon Steplewski, Jeffrey A. Mattis
  • Monoclonal antibodies against glycolipid antigens
    Patent number: 4971792
    Abstract: The present invention is directed to in vitro and in vivo immunodiagnosis and immunotherapy using monoclonal antibodies reactive with difucosyl blood group antigens Y-6 and B-7-2.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: November 20, 1990
    Assignee: The Wistar Institute
    Inventors: Zenon Steplewski, Hilary Koprowski, Magdelena Thurin
  • Monoclonal antibodies against melanoma-associated antigens and hybrid cell lines producing these antibodies
    Patent number: 4849509
    Abstract: The present invention is directed to monoclonal antibodies, and hybridomas which produce them, which are reactive with ganglioside antigens GD2 and GD3 and are essentially non-reactive with other ganglioside antigens. The invention further relates to methods of using these antibodies.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: July 18, 1989
    Assignee: The Wistar Institute
    Inventors: Jan Thurin, Hilary Koprowski, Meenhard Herlyn, Zenon Steplewski
  • Lewis blood group phenotype assay
    Patent number: 4607009
    Abstract: An assay for determining the Lewis blood group of a patient consists of testing a body sample for the presence of Lewis.sup.a and Lewis.sup.b antigens. Monoclonal antibodies specific for either of these antigens are employed which do not cross-react with other related antigens, such as the H blood antigen. Body samples which may be tested include: saliva, serum, urine, and paraffin-embedded tissue samples. Hybridoma cell lines and the antibody compositions they produce specific for these antigens are provided for use in the assay.
    Type: Grant
    Filed: September 16, 1983
    Date of Patent: August 19, 1986
    Assignee: The Wistar Institute
    Inventors: Zenon Steplewski, Hilary Koprowski, Meenhard Herlyn
  • Detection of colorectal carcinoma
    Patent number: 4471057
    Abstract: Colorectal carcinoma is detected by testing body fluids for the colorectal carcinoma monosialoganglioside identified by monoclonal antibodies produced by fused cell hybrid ATCC HB 8059.
    Type: Grant
    Filed: June 30, 1981
    Date of Patent: September 11, 1984
    Assignee: The Wistar Institute
    Inventors: Hilary Koprowski, Zenon Steplewski, Meenhard Herlyn
  • Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen
    Patent number: 4349528
    Abstract: It has been determined that 180,000 dalton molecular weight carcinoembryonic antigen has an antigen site which is not shared by other molecular weight carcinoembryonic antigens, which are released by colorectal carcinoma. A hybridoma antibody specific for the 180,000 dalton molecular weight carcinoembryonic antigen is described.
    Type: Grant
    Filed: November 21, 1979
    Date of Patent: September 14, 1982
    Assignee: The Wistar Institute
    Inventors: Hilary Koprowski, Kenneth F. Mitchell, Zenon Steplewski