Patents by Inventor Zequn Tang

Zequn Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF IMMUNE MODULATION AGAINST FOREIGN AND/OR AUTO ANTIGENS
    Publication number: 20190381157
    Abstract: The present invention is directed to compositions and methods of treating proliferative disorders, such as cancer, using a composition comprising an immune checkpoint antagonist and an antigen. It has been found that the composition elicits an immune response allowing an otherwise suppressed immune system to activate in order for T cells to attack cancer cells. Compositions may be presented in a vector comprising nucleic acids encoding the antagonist and antigen, and may include gene editing systems, such as CRISPR-Cas9 system.
    Type: Application
    Filed: January 29, 2018
    Publication date: December 19, 2019
    Inventor: ZEQUN TANG
  • Chimeric alphavirus replicon particles
    Patent number: 9255126
    Abstract: Chimeric alphavirus particles and alphavirus replicon RNAs are provided including methods of making and using same. The alphavirus replicon RNAs comprise deletions in one or more nonstructural proteins. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle are disclosed.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: February 9, 2016
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: John M. Polo, Silvia Perri, Kent Thudium, Zequn Tang
  • RNA expression cassette and cells for making alphavirus particles
    Patent number: 9234181
    Abstract: Strategies for increasing the productivity of alphavirus packaging cell lines and of reducing the possibility that replication competent virus may be generated during large scale production of recombinant alphavirus particles.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: January 12, 2016
    Assignee: Novartis AG
    Inventors: Zequn Tang, Jan zur Megede
  • Alphavirus replicon packaging constructs
    Patent number: 9024001
    Abstract: Provided herein are modified, functional 5? amplification sequences that are defective packaging signals. Also provided are compositions and methods comprising these modified 5? amplification sequences.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: May 5, 2015
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Zequn Tang, Silvia Perri, John Polo
  • METHODS OF GENERATING ALPHAVIRUS PARTICLES
    Publication number: 20110207223
    Abstract: Strategies for increasing the productivity of alphavirus packaging cell lines and of reducing the possibility that replication competent virus may be generated during large scale production of recombinant alphavirus particles.
    Type: Application
    Filed: November 26, 2008
    Publication date: August 25, 2011
    Inventors: Zequn Tang, Jan Zur Megede
  • CHIMERIC ALPHAVIRUS REPLICON PARTICLES
    Publication number: 20090304745
    Abstract: Chimeric alphavirus particles and alphavirus replicon RNAs are provided including methods of making and using same. The alphavirus replicon RNAs comprise deletions in one or more nonstructural proteins. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle are disclosed.
    Type: Application
    Filed: August 10, 2009
    Publication date: December 10, 2009
    Inventors: John M. Polo, Silvia Perri, Kent Thudium, Zequn Tang
  • Methods to enhance the stability and homogeneity of transgene expression in clonal cell lines
    Publication number: 20090215178
    Abstract: Strategies for increasing the productivity of recombinant protein expression in isogenic cell-lines. Development of a novel selection system for the improved stability and homogeneity of transgene expression in isogenic cells without the dependence on continuous selective drugs.
    Type: Application
    Filed: February 22, 2008
    Publication date: August 27, 2009
    Inventor: Zequn Tang
  • Alphavirus Replicon Packaging Constructs
    Publication number: 20080069804
    Abstract: Provided herein are modified, functional 5? amplification sequences that are defective packaging signals. Also provided are compositions and methods comprising these modified 5? amplification sequences.
    Type: Application
    Filed: May 20, 2005
    Publication date: March 20, 2008
    Inventors: Zequn Tang, Silvia Perri, John Polo
  • Chimeric alphavirus replicon particles
    Publication number: 20030232324
    Abstract: Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle, are disclosed.
    Type: Application
    Filed: December 4, 2002
    Publication date: December 18, 2003
    Applicant: Chiron Corporation
    Inventors: John M. Polo, Silvia Perri, Kent Thudium, Zequn Tang