Patents by Inventor Zev A. Binder

Zev A. Binder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods Comprising a High Affinity Chimeric Antigen Receptor (CAR) with Cross-Reactivity to Clinically-Relevant EGFR Mutated Proteins
    Publication number: 20220184129
    Abstract: The present invention includes compositions and methods that utilize a high affinity chimeric antigen receptor (CAR) with cross-reactivity to clinically-relevant EGFR mutated proteins.
    Type: Application
    Filed: April 11, 2020
    Publication date: June 16, 2022
    Inventors: Donald O'ROURKE, Zev BINDER, Michael MILONE, Radhika THOKALA
  • SYNTHETIC CARS TO TREAT IL13R-alpha-2 POSITIVE HUMAN AND CANINE TUMORS
    Publication number: 20210128617
    Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g. T cells) comprising chimeric antigen receptors (CARs) capable of binding human IL13R?2. Also provided are bispecific CARs, parallel CARs, tandem CARs, BiTEs, BiTE/CARs, and BiTE/BiTEs. Compositions and methods of treatment are also provided.
    Type: Application
    Filed: August 27, 2020
    Publication date: May 6, 2021
    Inventors: Donald M. O'Rourke, Yibo Yin, Laura Johnson, Zev Binder, Radhika Thokala
  • System and device for characterizing cells
    Patent number: 9435738
    Abstract: A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 6, 2016
    Assignees: The Johns Hopkins University, University of Florida
    Inventors: Denis Wirtz, Pei-Hsun Wu, Shyam B. Khatau, Wei-Chang Chen, Jude M. Phillip, Jr., Zev A. Binder, Yiider Tseng
  • SYSTEM AND DEVICE FOR CHARACTERIZING CELLS
    Publication number: 20150093779
    Abstract: A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 2, 2015
    Applicants: The Johns Hopkins University, University of Florida
    Inventors: Denis Wirtz, Pei-Hsun Wu, Shyam B. Khatau, Wei-Chang Chen, Jude M. Phillip, JR., Zev A. Binder, Yiidar Tseng