Patents by Inventor Zhaohui Sunny Zhou

Zhaohui Sunny Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
    Patent number: 11129790
    Abstract: A method is provided for reversibly modifying a protein or peptide on its glutamine residue(s) by performing a reaction, such as a transglutaminase-catalyzed reaction, between the protein or peptide and an amine-containing reagent, whereby the reagent is linked through its amine function to a side chain of the glutamine residue. Subjecting the modified protein to an appropriate stimulus regenerates the protein or peptide in its original form.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 28, 2021
    Assignee: Northeastern University
    Inventors: Zhaohui Sunny Zhou, George O'Doherty, Shanshan Liu, Kevin Ryan Moulton, Lincoln Ombelets, Amissi Sadiki
  • Chemo-Enzymatic Site-Specific Modification of Peptides and Proteins to Form Cleavable Conjugates
    Publication number: 20180369131
    Abstract: A method is provided for reversibly modifying a protein or peptide on its glutamine residue(s) by performing a reaction, such as a transglutaminase-catalyzed reaction, between the protein or peptide and an amine-containing reagent, whereby the reagent is linked through its amine function to a side chain of the glutamine residue. Subjecting the modified protein to an appropriate stimulus regenerates the protein or peptide in its original form.
    Type: Application
    Filed: May 21, 2018
    Publication date: December 27, 2018
    Inventors: Zhaohui Sunny ZHOU, George O'DOHERTY, Shanshan LIU, Kevin Ryan MOULTON, Lincoln OMBELETS, Amissi SADIKI
  • Se-Adenosyl-L-Selenohomocysteine Selenoxide As A Modulator Of Methyltransferase And Other Activities
    Publication number: 20160090397
    Abstract: The invention relates to a compound of the structural formula or a hydrate or an isotope thereof. The invention also relates to a preparation method thereof and methods of providing dietary organoselenium, inactivating an enzyme, modulating the activity of a protein (e.g., methyltransferase) or nucleic acid, identifying a methyltransferase that reacts with compound, and oxidizing a methyltransferase-reactive substrate.
    Type: Application
    Filed: September 30, 2015
    Publication date: March 31, 2016
    Inventors: Zhaohui Sunny Zhou, Richard I. Duclos, JR., Dillon C. Cleary, Kalli C. Catcott
  • Compositions and Methods for the Inhibition of Methyltransferases
    Publication number: 20150057243
    Abstract: Methods and compositions disclosed herein relate to detecting, analyzing, isolating and inhibiting methyltransferases, methyltransferase substrates, S-adenosyl-methionine-binding proteins and RNA, including for the treatment of disease.
    Type: Application
    Filed: April 2, 2013
    Publication date: February 26, 2015
    Applicant: Northern University
    Inventors: Zhaohui Sunny Zhou, Wanlu Qu, Tianyi Bai