Abstract: The cationic lipid compound and composition for delivering nucleic acids as shown in formula (I) and their use are disclosed. The use of nano lipid particles with the compound as a key component in nucleic acid delivery is also disclosed, including the composition, preparation method, and usage method of the delivery carrier.

Abstract: A lens unit, a lens for a low-beam illumination module, a low-beam illumination module and a vehicle. The lens unit includes a rear surface and a front surface; the lens unit has a focal line, and the focal line is a straight line perpendicular to a light emitting direction of the lens unit; the rear surface and the front surface are adapted to project light rays passing through the focal line into parallel light rays, and the front surface is a free-form curved surface. The lens unit has the optical characteristics of a cylindrical lens, and is able to cause parallel incident light to be focused into a line instead of a focal point upon passing through the lens unit.

Abstract: A JAK inhibitor may be used in preparation of a medicament. The medicament may be used for preventing and/or treating a disease or condition associated with an antitumor agent in a subject. A pharmaceutical composition may include the JAK inhibitor as may a kit. The JAK inhibitor may include a compound of formula (I) or a pharmaceutically acceptable salt thereof: Q, X, Y, and Z being independently N or C, and R1, R2 and R3 being independently a 5-6-membered aromatic ring, 5-6-membered heteroaromatic ring, 5-6-membered cycloalkyl, 5-6-membered heterocycloalkyl, amino, or amido, the aromatic ring, heteroaromatic ring, cycloalkyl, and/or heterocycloalkyl being optionally substituted by a substituent.

Abstract: An automotive headlamp system and an automotive lamp. The automotive headlamp system comprises a light source, a primary optical element, an automotive signal lamp structure, and a secondary optical element arranged sequentially along the light emitting direction. The automotive signal lamp structure comprises a light-transmitting portion and a rotating shaft. The light-transmitting portion comprises at least one light-transmitting plate mounted on the rotating shaft which can be driven to rotate by the rotating shaft. By means of rotation, light from the light source exits from the primary optical element, then selectively passes through one of or none of the light-transmitting plates, and is then projected by means of the secondary optical element to achieve a corresponding signal lamp function. The light-transmitting plate mounted on the rotating shaft is used to replace an existing signal lamp, reducing the space occupied by the original signal lamp, decreasing the volume of a headlamp.

Abstract: A control circuit accesses a memory having time series acquisition history data for members of a predetermined group. That control circuit is configured to predict at least one future aggregation of items on a per-member basis by (1) using machine learning to predict specific items in the at least one future aggregation of items, wherein the machine learning uses a training corpus comprising, at least in part, the aforementioned time series acquisition history data, and (2) using matrix factorization to predict a quantity of at least some of the specific items in the at least one future aggregation of items.

Abstract: Systems, apparatuses, and methods are provided herein for network incident management. A method for network incident management comprises aggregating network metrics associated with a monitored network in a historical network data database, identifying incidents based on the network metrics, generating a training data set based on the network metrics and the incidents, wherein the training data set comprises time series of network metrics as training input and incidents as labels, training an incident model using the training data set, receiving real-time network metrics from the network via the network interface, determining an incident prediction based on the incident model using the real-time network metrics as input, and causing a user interface device to provide an alert to a user based on the incident prediction.

Abstract: The disclosure discloses a charging valve, an air conditioning system and an electric vehicle. The charging valve includes: an outer valve body including a first inner cavity, the outer valve body is provided with a connection port in communication with the first inner cavity; an inner valve body movably installed in the first inner cavity, the inner valve body has a sealing position for closing the connection port and a charging position for opening the connection port, and the inner valve body is provided with a second inner cavity; and a valve core assembly, installed in the second inner cavity. The inner valve body of such a charging valve realizes the isolation of the valve core assembly from the connection port. A problem that air enters the air conditioning system in a vacuum state or that leakage appears in the valve core assembly is avoided.

Abstract: Described herein are systems and methods for determining a logical starting location to start providing (e.g., reading) content to a user. When the user navigates to a particular web page and/or email message, a screen reader can automatically read content associated with the web page and/or email message beginning at the determined logical starting location. A heuristic can be applied in order to determine the logical starting location. The heuristic can analyze information regarding user interface element(s) (e.g., property(ies) and/or attribute(s)) of the particular webpage and/or email message to find a logical location to start reading once the webpage and/or email message have loaded.

Abstract: The disclosure discloses a charging valve, an air conditioning system and an electric vehicle. The charging valve includes: an outer valve body including a first inner cavity, the outer valve body is provided with a connection port in communication with the first inner cavity; an inner valve body movably installed in the first inner cavity, the inner valve body has a sealing position for closing the connection port and a charging position for opening the connection port, and the inner valve body is provided with a second inner cavity; and a valve core assembly, installed in the second inner cavity. The inner valve body of such a charging valve realizes the isolation of the valve core assembly from the connection port. A problem that air enters the air conditioning system in a vacuum state or that leakage appears in the valve core assembly is avoided.

Abstract: Described herein are systems and methods for determining a logical starting location to start providing (e.g., reading) content to a user. When the user navigates to a particular web page and/or email message, a screen reader can automatically read content associated with the web page and/or email message beginning at the determined logical starting location. A heuristic can be applied in order to determine the logical starting location. The heuristic can analyze information regarding user interface element(s) (e.g., property(ies) and/or attribute(s)) of the particular webpage and/or email message to find a logical location to start reading once the webpage and/or email message have loaded.

Abstract: Disclosed herein is a sealing device disposed between a vehicle door and a vehicle body and a vehicle door sealing rubber strip thereof. The sealing rubber strip is sleeved on a door pipe of the vehicle door. The vehicle door sealing rubber strip is an annular rubber body constituted by a drain segment and a non-drain segment. The annular rubber body includes a hollow rubber ring made of foaming rubber and a groove-shaped rubber ring made of compacted solid rubber and provided with a pipe body mounting groove at the inner side of the groove-shaped rubber ring. An air hole is provided in the hollow rubber ring, and a small water flowing trench is provided at the bottom surface of the pipe body mounting groove of the groove-shaped rubber ring. A fixing groove with a broad bottom and a narrow opening is provided on one external side of the groove-shaped rubber ring.

Abstract: Disclosed herein is a vehicle door with an irregular-circular frame for a recreational vehicle. A door window glass of the vehicle door includes a fixed glass (2) and a movable glass (1). The fixed glass (2) is fixedly installed in a portion of the door window surrounded by a lower door body (6), an outer frame (5) and a movable glass guide rail (9). The movable glass guild rail (9) has an arc rail. The movable glass (1) is installed on the lower door body (6) at the center of the arc of the movable glass guide rail (9) via a shaft sleeve and a shaft (4). A lock member (3) with a lock pin is installed on the upper part of the portion where the movable glass (1) engages with the movable glass guide rail (9). A stop block for adjusting the opening degree of the movable glass and stopping the lock pin of the lock member (3) is provided on the movable glass guide rail (9).

Abstract: Disclosed herein is a sealing device disposed between a vehicle door and a vehicle body and a vehicle door sealing rubber strip thereof. The sealing rubber strip is sleeved on a door pipe of the vehicle door. The vehicle door sealing rubber strip is an annular rubber body constituted by a drain segment and a non-drain segment. The annular rubber body includes a hollow rubber ring made of foaming rubber and a groove-shaped rubber ring made of compacted solid rubber and provided with a pipe body mounting groove at the inner side of the groove-shaped rubber ring. An air hole is provided in the hollow rubber ring, and a small water flowing trench is provided at the bottom surface of the pipe body mounting groove of the groove-shaped rubber ring. A fixing groove with a broad bottom and a narrow opening is provided on one external side of the groove-shaped rubber ring.

Abstract: Disclosed herein is a vehicle door with an irregular-circular frame for a recreational vehicle. A door window glass of the vehicle door includes a fixed glass (2) and a movable glass (1). The fixed glass (2) is fixedly installed in a portion of the door window surrounded by a lower door body (6), an outer frame (5) and a movable glass guide rail (9). The movable glass guild rail (9) has an arc rail. The movable glass (1) is installed on the lower door body (6) at the centre of the arc of the movable glass guide rail (9) via a shaft sleeve and a shaft (4). A lock member 3 with a lock pin is installed on the upper part of the portion where the movable glass 1 engages with the movable glass guide rail (9). A stop block for adjusting the opening degree of the movable glass and stopping the lock pin of the lock member (3) is provided on the movable glass guide rail (9).