Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of angiotensinogen (AGT). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT protein in a cell or animal.

Abstract: A battery cell, a battery, an electrical device, and a device and method for manufacturing a battery cell are described. The battery cell includes a shell, an electrode assembly, and a current collecting member, where the electrode assembly is accommodated in the shell, and the electrode assembly is provided with a tab; the current collecting member includes a first connecting part and a second connecting part which are connected, the first connecting part is used to be welded to the tab, and the second connecting part is used to be welded to the shell; and the first connecting part and the second connecting part are made of different materials, the first connecting part and the tab are made of the same material, and the second connecting part and the shell are made of the same material.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of Complement Factor B (CFB). In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB mRNA in a cell or animal. In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB protein in a cell or animal.

Abstract: RNAi agents for inhibiting the expression of the alpha-1 antitrypsin (AAT) gene, compositions including AAT RNAi agents, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more AAT RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the AAT RNAi agent(s) to liver cells in vivo inhibits AAT gene expression and treats diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, and fulminant hepatic failure.

Abstract: The present application relates to a network-on-chip data processing method. The method is applied to a network-on-chip processing system, the network-on-chip processing system is used for executing machine learning calculation, and the network-on-chip processing system comprises a storage device and a calculation device. The method comprises: accessing the storage device in the network-on-chip processing system by means of a first calculation device in the network-on-chip processing system and obtaining first operation data; performing an operation on the first operation data by means of the first calculation device to obtain a first operation result; and sending the first operation result to a second calculation device in the network-on-chip processing system. According to the method, operation overhead can be reduced and data read/write efficiency can be improved.

Abstract: The present application relates to a network-on-chip data processing method. The method is applied to a network-on-chip processing system, the network-on-chip processing system is used for executing machine learning calculation, and the network-on-chip processing system comprises a storage device and a calculation device. The method comprises: accessing the storage device in the network-on-chip processing system by means of a first calculation device in the network-on-chip processing system and obtaining first operation data; performing an operation on the first operation data by means of the first calculation device to obtain a first operation result; and sending the first operation result to a second calculation device in the network-on-chip processing system. According to the method, operation overhead can be reduced and data read/write efficiency can be improved.

Abstract: A method for calculating flexural capacity of a steel plate-reinforced joint in shield tunnel includes: (S1) obtaining a construction parameter, a material parameter, and a mechanical parameter of a joint surface; and calculating a virtual strain ?sp,0a height xcb1 of a critical compression zone for bolt yielding in case of section failure, and a height xcb1 of a critical compression zone for steel plate yielding; (S2) calculating a height xc of a compression zone of a joint surface of the steel plate-reinforced joint in a certain failure state; (S3) determining whether xc satisfies a range requirement: if so, executing step (S4); and if no, replacing a new failure state; and skipping to step (S2) until traversing all failure states; and (S4) substituting xc into a bending moment equilibrium equation for the current failure state; and calculating an ultimate bending moment. A computer-readable storage medium is further provided.

Abstract: The present application relates to a network-on-chip data processing method. The method is applied to a network-on-chip processing system, the network-on-chip processing system is used for executing machine learning calculation, and the network-on-chip processing system comprises a storage device and a calculation device. The method comprises: accessing the storage device in the network-on-chip processing system by means of a first calculation device in the network-on-chip processing system and obtaining first operation data; performing an operation on the first operation data by means of the first calculation device to obtain a first operation result; and sending the first operation result to a second calculation device in the network-on-chip processing system. According to the method, operation overhead can be reduced and data read/write efficiency can be improved.

Abstract: Systems and methods for upgrading container images within orchestration systems. In various embodiments, a request to run a custom container image can be received. Subsequently, a determination can be made as to whether the current version of the requested custom container image is built upon a most recent version of a corresponding base container image. Where it is determined that the current version of the requested custom container image is not built upon the most recent version of the corresponding base container image, an upgraded version of the custom container image can be generated. Advantageously, a non-privileged user requesting a custom container image can, leveraging the private access token and/or administrative privileges of the system, be able to upgrade the requested custom container image. Custom container images can be automatically upgraded, and relied upon to be up-to-date when used, without burdening the user.

Abstract: A shower head fixing structure includes a valve seat assembly and a shower head body. A clamping groove is disposed on the valve seat assembly; a fixing apparatus clamped with the clamping groove is disposed on the shower head body; the fixing apparatus includes a sliding member and a fixing arm; the fixing arm can be clamped in the clamping groove; the sliding member is capable of moving to drive the fixing arm to rotate, enabling the fixing arm to clamp the shower head body; the fixing apparatus further includes a spring capable of driving the fixing arm to move towards the clamping groove. The shower head fixing structure is provided with a self-locking structure, and a shower head is not easy to fall off after being fixed.

Abstract: The disclosure discloses a magnesium alloy material smelting device, comprising a furnace, a disc packing device, the disc packing device comprising a stirring shaft, a packing basket, a disc stirring head, the stirring shaft connected with a packing basket, the bottom of the packing basket connected with a disc stirring head, the disc stirring head comprising a plurality of stirring wings, the stirring wings connected with the packing basket and the stirring disc, the connecting ends of the stirring wings connected with each other, the stirring ends extending to the edge of the stirring disc, and the sidewall of the packing basket provided with a liquid passage hole; during the process of preparing and processing the magnesium alloy, the disc stirring head may accelerate the diffusion, the rotation of the disc stirring head may divide the melt into upper and lower layers, and the upper layer of the melt forms a solution vortex to accelerate the diffusion of the master alloy elements; the lower melt keeps rel

Abstract: A method for circuit design based on Artificial Intelligence (AI) and an implementation system thereof. Subcircuits of a circuit-design topology of a historical phase, which are of different categories, are classified and a first feature model are obtained by training; a feature parameter of a circuit is acquired, and finally, the circuit feature parameter is compared with an expected parameter and a corresponding determination result is obtained, thereby a determination is able to be provided for the circuit design, and no simulation is required. As a result, an adjustment on the circuit design or an optimization on the circuit can be performed at a proper time, accordingly, the efficiency in design can be improved.

Abstract: This application relates to the field of electric digital data processing, and specifically to an efficient circuit simulation method and apparatus, a device, and a storage medium. The method includes: obtaining sub-circuit modules in a target circuit; performing function fitting processing on the sub-circuit modules to obtain fitting functions corresponding to the sub-circuit modules; and replacing, based on a logical relationship among the sub-circuit modules, the target circuit with the fitting functions respectively corresponding to the sub-circuit modules for simulation processing to obtain a simulation result of the target circuit. According to the foregoing solution, the target circuit is replaced with the fitting functions corresponding to the sub-circuit modules to perform simulation, a target circuit matrix with complex data does not need to be constructed, and the simulation efficiency of the circuit is improved.

Abstract: The present application discloses a chip design method using secondary development capability of EDA software. On the basis of a chip having design and verification of a main function being completed, the feature steps comprise: customizing and adding, on an EDA software development platform, parameters required for an operating environment corresponding to the chip, automatically adding a schematic diagram of at least one of an environmental stabilization system used for implementing temperature compensation and an environmental stabilization system used for implementing electromagnetic shielding, combining same with a chip schematic diagram and drawing to obtain a layout.

Abstract: A refrigerator production line and a method for upgrading a refrigerator software of an assembled refrigerator on the refrigerator production line are provided. The refrigerator production line includes a conveying device for conveying an assembled refrigerator; a scanning device for scanning and confirming an identification code of the assembled refrigerator and an address code of a communication module in the assembled refrigerator; and a local server for saving the identification code of the assembled refrigerator and the address code of the communication module and further acquiring, in response to a firmware upgrade request, a firmware upgrading package for the assembled refrigerator that corresponds to the identification code. After the assembled refrigerator is powered on, the communication module receives the firmware upgrade package, and a control module upgrades a public version software program according to the firmware upgrade package.

Abstract: Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B virus gene are described. The HBV RNAi agents disclosed herein may be targeted to cells, such as hepatocytes, for example, by using conjugated targeting ligands. Pharmaceutical compositions comprising one or more HBV RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi agents to infected liver in vivo provides for inhibition of HBV gene expression and treatment of diseases and conditions associated with HBV infection.

Abstract: The present application relates to a network-on-chip data processing method. The method is applied to a network-on-chip processing system, the network-on-chip processing system is used for executing machine learning calculation, and the network-on-chip processing system comprises a storage device and a calculation device. The method comprises: accessing the storage device in the network-on-chip processing system by means of a first calculation device in the network-on-chip processing system, and obtaining first operation data; performing an operation on the first operation data by means of the first calculation device to obtain a first operation result; and sending the first operation result to a second calculation device in the network-on-chip processing system. According to the method, operation overhead can be reduced and data read/write efficiency can be improved.

Abstract: This disclosure provides a packaging structure for a display substrate, a packaging method and a display device. The packaging structure for the display substrate includes a base substrate, a light-emitting device arranged on the base substrate, and a packaging thin film covering the light-emitting device. The packaging thin film includes an inorganic thin film and an organic thin film that are laminated, and the organic thin film is arranged on a surface of the inorganic thin film away from the base substrate. The packaging thin film includes a central region and a peripheral region surrounding the central region, the inorganic thin film located in the central region has surface energy greater than that of the inorganic thin film in the peripheral region, and the organic thin film in the central region has a thickness less than that of the organic thin film in the peripheral region.