Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of ophthalmologic diseases, including non-proliferative diabetic retinopathy (NPDR), diabetic macular edema (DME), retinal ganglion cell/photoreceptor neurodegeneration and cataract.

Abstract: Provided are a system and method for implementing an incremental data comparison. The system includes: a synchronization T environment, a simulation F environment, a simulation tool, a memory database, a comparison tool and a result database. The T environment includes a synchronization environment core application, a traditional commercial database, an incremental synchronization tool and a synchronization environment distributed database. The F environment includes a simulation environment core application and a simulation environment distributed database. The simulation tool is configured to play back a T environment service and an F environment service. The memory database is configured to store a mapping relationship between message values of the T and F environment. The comparison tool is configured to compare data in the T and F environment according to the mapping relationship between the message values.

Abstract: A handheld gimbal may include a body and a control assembly. The body may include one or more axis assemblies. Each of the one or more axis assemblies may include an arm and a motor for driving the arm to move around an axis. The control assembly may be configured to detect a change of a configuration of the handheld gimbal. The control assembly may also be configured to control at least one of the motors of the one or more axis assemblies to move the respective arm under a joint angle control mode.

Abstract: An adjustment structure and an adjustment method therefor, a sealing member, a coaxial cable, a gimbal and a mobile apparatus are provided. The arm adjustment structure includes a base, an arm, and a sealing member. The arm is capable of moving relative to the base, and a clearing slot is disposed on the arm. The sealing member is disposed between the base and the arm, and is capable of being located at the clearing slot to cover the clearing slot. The sealing member is disposed between the base and the arm, and capable of being located at the clearing slot to cover the clearing slot to prevent the clearing slot from being exposed, and prevent foreign matters such as water droplets, sand, and dust from entering the gimbal through the clearing slot and affecting normal use of the gimbal.

Abstract: A follow-focus wheel assembly includes a supporting member, a follow-focus plate, and a follow-focus wheel. The supporting member includes a supporting seat and a mounting seat formed by extending outward from the supporting seat; the follow-focus plate and the follow-focus wheel are located on two sides of the mounting seat respectively, and the follow-focus wheel passes through a through hole on the mounting seat and then connects to the follow-focus plate in a rotatable manner. The supporting member is used for connecting an external structure, and the follow-focus wheel assembly is mounted in the external structure via the supporting member, where the follow-focus wheel partially extends out of the external structure when the supporting member is connected to the external structure. The follow-focus wheel assembly has a simple and compact structure, and can be miniaturized. It meets the requirement of performing a focusing operation with a single hand.

Abstract: The present invention relates to compositions and methods utilizing anti-TNF antibodies, e.g., the anti-TNF antibody golimumab having a heavy chain (HC) comprising an amino acid sequence of SEQ ID NO:36 and a light chain (LC) comprising an amino acid sequence of SEQ ID NO:37, for use in the treatment of juvenile idiopathic arthritis (JIA), and in particular for polyarticular juvenile idiopathic arthritis (pJIA).

Abstract: In one aspect, GLP-1r agonists including long-acting PEGylated exenatide (NLY01), exenatide, liraglutide, exenatide LAR (long acting), taspoglutide, albiglutide, dulaglutide, lixisenatide, semaglutide, LY2189265 are used to treat ocular ischemic, inflammatory, angiogenic, and/or degenerative conditions.

Abstract: The present invention relates to compositions and methods utilizing anti-TNF antibodies, e.g., the anti-TNF antibody golimumab having a heavy chain (HC) comprising an amino acid sequence of SEQ ID NO:36 and a light chain (LC) comprising an amino acid sequence of SEQ ID NO:37, for use in the treatment of juvenile idiopathic arthritis (JIA), and in particular for polyarticular juvenile idiopathic arthritis (pJIA).

Abstract: Methods for predicting pharmacokinetics of an Immunoglobulin G (IgG) therapeutic protein based on a patient's level of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), or RF and ACPA. Methods disclosed herein also relate to methods for determining the therapeutically effective dose of an IgG therapeutic protein based on the levels of RF, ACPA, or RF and ACPA.

Abstract: An unmanned aerial vehicle (UAV) includes a body and a gimbal camera. The body includes a housing including an inwardly recessed mounting groove with a notch on one side of the mounting groove, and a protective cover arranged at the housing and configured to open and cover the notch. The gimbal camera includes a mounting frame detachably connected to the housing via the mounting groove; a gimbal arranged at the mounting frame; and a camera arranged at the gimbal. In response to the gimbal camera and the housing being connected via the mounting frame, the gimbal camera is at least partially accommodated in the notch.

Abstract: Provided are a method and apparatus for evaluating a degree of frequency regulation urgency of a generator set, a power system and a storage medium.

Abstract: Methods, systems, and devices for processing and answering a natural language query at a database server are described. An end user may submit a question in natural language over a communication platform. An answer engine running on the database server may receive the question, and may process the content of the question using natural language processing (NLP) techniques. The answer engine may construct a search query based on the NLP, and may retrieve a set of documents from a database using the search query. The answer engine may rank the documents, prune the number of documents, modify the documents for the given communication platform, or perform any combination of these functions. In some cases, an intermediate user may review the documents, and may select one or more documents for publication. The answer engine may send the selected documents to the end user as answers in response to the question.

Abstract: An application server platform operated by a cloud computing services provider receives input from a customer organization application executing on the application server platform, the input specifying a first action on a first item type, and a second action on a second item type to recommend in response to the specified first action on the first item type. The application server platform searches for a record in a permanent data store that contains the first action, the first item type, the second action, and the second item type, and assigns a value to a token associated with the record based on when the application server platform most recently generated a recommendation that included the first action on the first item type and the second action on the second item type from the record, when the search locates the record in the permanent data store.

Abstract: An adjustment structure and an adjustment method therefor, a sealing member, a coaxial cable, a gimbal and a mobile apparatus are provided. The arm adjustment structure includes a base, an arm, and a sealing member. The arm is capable of moving relative to the base, and a clearing slot is disposed on the arm. The sealing member is disposed between the base and the arm, and is capable of being located at the clearing slot to cover the clearing slot. The sealing member is disposed between the base and the arm, and capable of being located at the clearing slot to cover the clearing slot to prevent the clearing slot from being exposed, and prevent foreign matters such as water droplets, sand, and dust from entering the gimbal through the clearing slot and affecting normal use of the gimbal.

Abstract: A follow-focus wheel assembly includes a supporting member, a follow-focus plate, and a follow-focus wheel. The supporting member includes a supporting seat and a mounting seat formed by extending outward from the supporting seat; the follow-focus plate and the follow-focus wheel are located on two sides of the mounting seat respectively, and the follow-focus wheel passes through a through hole on the mounting seat and then connects to the follow-focus plate in a rotatable manner. The supporting member is used for connecting an external structure, and the follow-focus wheel assembly is mounted in the external structure via the supporting member, where the follow-focus wheel partially extends out of the external structure when the supporting member is connected to the external structure. The follow-focus wheel assembly has a simple and compact structure, and can be miniaturized. It meets the requirement of performing a focusing operation with a single hand.

Abstract: A headset body includes a mounting base, an adjusting base matching the mounting base, and a connecting mechanism mounted at an end of the mounting base and extending into the adjusting base. The connecting mechanism includes an elastic member configured to adjust a wearing space formed between the mounting base and the adjusting base.

Abstract: A video glasses headband includes a first head-ring-body, a second head-ring-body connected to the first head-ring-body, a docking assembly arranged at the first head-ring-body and configured to cooperate with video glasses, and an antenna assembly including an antenna arranged inside one of the first head-ring-body and the second head-ring-body.

Abstract: A video glasses headband includes a first head-ring-body, a second head-ring-body connected to the first head-ring-body, a docking assembly arranged at the first head-ring-body and configured to cooperate with video glasses, and a battery assembly arranged inside the second head-ring-body and including a battery.

Abstract: An unmanned aerial vehicle includes a fuselage and a plurality of arm assemblies disposed at the fuselage. Each arm assembly includes an arm connected to the fuselage and a drive mechanism for driving the arm to rotate. The arm includes an unfolded state and a folded state. Each drive mechanism is configured to drive a corresponding arm to rotate relative to the fuselage and to enable a switching between the unfolded state and the folded state of the corresponding arm.

Abstract: Provided are methods of subcutaneous administration of anti-CD38 monoclonal antibodies, such as daratumumab. Also provided are methods for the treatment of autoimmune diseases with subcutaneously administered anti-CD38 monoclonal antibodies. A corticosteroid is optionally administered prior to subcutaneous administration of the anti-CD38 antibody to prevent and/or reduce systemic injection related side effects.