Abstract: Automatic error recovery systems and methods for automated manufacturing plants and factories are disclosed. Such facilities normally have multiple automated control systems, including an automated material handling system (AMHS), all of which run automatically, typically under the control of a computerized manufacturing execution system (MES). The disclosed issue resolution (ISR) systems and methods involve providing components, which may be supervised and operated by an issue resolution management (ISRM) system, if desired, that interfaces with the MES, AMHS, and/or production control system(s) which operate the tools and other stations within the automated factory. The components, which may be considered customized logic cells, may each be written for handling a specific kind of incoming error condition, problem or other issue that might occur and which is amenable to automatic resolution or recovery.