Abstract: A novel indoleamine 2,3-dioxygenase inhibitor and/or its pharmaceutically acceptable salts can used, in the preparation of a drug for indoleamine 2,3-dioxygenase (IDO) related diseases, such as cancer, Alzheimer's, depression, cataract, etc.

Abstract: The present invention provides a novel indoleamine 2,3-dioxygenase inhibitor, a preparation method thereof, and a pharmaceutical composition, in which the definitions of n, Y, Z, R1, R2, R3, and R4 are as stated in the specification. Also provided is a use of the aforementioned compound and pharmaceutically acceptable salts and isomers thereof in the preparation of a drug for indoleamine 2,3-dioxygenase (IDO) related disease, specifically a use in the treatment of major diseases such as cancer, Alzheimer's, depression, cataract, etc. The compound of the invention has improved activity, potential medicinal value, and wide market prospects.

Abstract: An oral functional appliance for adjusting functions of oral muscle organs includes a base and a body. The base is connected to a tooth surface, and the body is provided with at least one protrusion at a surface thereof.

Abstract: Disclosed herein relates to an orthodontic appliance, in particular to an orthodontic appliance connected to a tooth and coacting with an archwire. The orthodontic appliance has at least one archwire slot extending through mesiodistally. At least one sub-slot opening to the archwire slot is provided in the sidewalls of the archwire slot. The above-mentioned configurations facilitate the movement of the tooth mesiodistally. With different archwires and different ligation manners, the position of the archwire in the archwire slot can be controlled, thus it is easy to tip teeth mesiodistally and to upright the teeth mesiodistally with small force. The orthodontic appliance has simple structure, and with which it is not necessary to employ extraoral force and mini-implant to strengthen the anchorage.