Patents by Inventor Zhi-Ying Chen
Zhi-Ying Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240146864Abstract: A landmark identification and marking system for a panoramic image is provided. The system includes a storage device and a back-end processor. The storage device stores an initial panoramic image, attitude information, motion tracking information, and a landmark list. The back-end processor performs steps of: adjusting a visual angle of the initial panoramic image to a designated angle according to a difference value between the visual angle and the designated angle; providing the adjusted initial panoramic image to a front-end processor for calculating and generating a panoramic image integrated with landmark objects in the virtual space.Type: ApplicationFiled: November 18, 2022Publication date: May 2, 2024Applicant: INSTITUTE FOR INFORMATION INDUSTRYInventors: Jia-Hao WANG, Zhi-Ying CHEN, Hsun-Hui HUANG, Chien-Der LIN
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Publication number: 20240119843Abstract: A ship navigation display system is set in a ship and includes a communications device, sensing device, first computing device, second computing device and wearable device. The communications device receives first coordinate information corresponding to a ship. The sensing device senses second coordinate information corresponding to a first ship around the ship. The first computing device is communicably connected with the communications device and calculates a collision probability according to the first and second coordinate information. When the collision probability is greater than a threshold value, the first computing device transmits a collision prediction signal. The second computing device receives the collision prediction signal and projects the second coordinate information corresponding to the first ship to a virtual coordinate in a virtual space.Type: ApplicationFiled: November 11, 2022Publication date: April 11, 2024Inventors: Jia Hao Wang, Zhi Ying Chen, Hsun Hui Huang, Chien Der Lin
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Publication number: 20230062311Abstract: A sports injury sensing system and method are provided. The sports injury sensing system includes a sports injury sensing apparatus. The apparatus receives a plurality of inertial sensing data of a user, and each of the inertial sensing data corresponds to a body part of the user. The apparatus determines an exercising body part of the user based on the inertial sensing data. The apparatus receives a thermal image sensing datum corresponding to the exercising body part, wherein the thermal image sensing datum indicates a body temperature state of the user. The apparatus analyzes a temperature change of surrounding muscles of the exercising body part based on the thermal image sensing datum. The apparatus calculates a sports injury assessment based on the inertial sensing data and the temperature change of surrounding muscles.Type: ApplicationFiled: October 15, 2021Publication date: March 2, 2023Inventors: Zhi Ying CHEN, Hsun-Hui HUANG, Chia Hao WANG, Shr Yau JAN, Chien-Der LIN
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Patent number: 10612030Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: GrantFiled: July 18, 2017Date of Patent: April 7, 2020Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mark A. Kay, Zhi-Ying Chen
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Publication number: 20180010135Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: ApplicationFiled: July 18, 2017Publication date: January 11, 2018Inventors: Mark A. Kay, Zhi-Ying Chen
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Patent number: 9745590Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: GrantFiled: September 8, 2014Date of Patent: August 29, 2017Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mark A. Kay, Zhi-Ying Chen
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Patent number: 9233174Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.Type: GrantFiled: February 2, 2015Date of Patent: January 12, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Zhi-Ying Chen, Mark A. Kay
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Publication number: 20150217000Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.Type: ApplicationFiled: February 2, 2015Publication date: August 6, 2015Inventors: Zhi-Ying CHEN, Mark A. KAY
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Publication number: 20150184131Abstract: Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.Type: ApplicationFiled: January 6, 2015Publication date: July 2, 2015Inventors: Joseph Wu, Michael T. Longaker, Mark A. Kay, Ning Sung, FangJun Jia, Zhi-Ying Chen, Nicholas Panetta, Deepak Gupta
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Publication number: 20150079636Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: ApplicationFiled: September 8, 2014Publication date: March 19, 2015Inventors: Mark A. Kay, Zhi-Ying Chen
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Patent number: 8962331Abstract: Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.Type: GrantFiled: February 1, 2011Date of Patent: February 24, 2015Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Joseph Wu, Michael T. Longaker, Mark A. Kay, Ning Sung, FangJun Jia, Zhi-Ying Chen, Nicholas Panetta, Deepak Gupta
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Patent number: 8945885Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.Type: GrantFiled: August 6, 2012Date of Patent: February 3, 2015Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Zhi-Ying Chen, Mark A. Kay
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Patent number: 8828726Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: GrantFiled: April 4, 2006Date of Patent: September 9, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mark A. Kay, Zhi-Ying Chen
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Patent number: 8445454Abstract: Compositions and methods are provided for the treatment of an ischemic cardiovascular condition by providing a patient with a novel non-viral minicircle DNA vector comprising polynucleotide sequences that potentiate HIF-1 activity, including RNAi or antisense agents selective for proteins involved in HIF1 inactivation.Type: GrantFiled: October 22, 2010Date of Patent: May 21, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Joseph Wu, Mark A. Kay, Mei Huang, Zhi-Ying Chen
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Publication number: 20130034882Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.Type: ApplicationFiled: August 6, 2012Publication date: February 7, 2013Inventors: ZHI-YING CHEN, MARK A. KAY
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Patent number: 8236548Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.Type: GrantFiled: July 2, 2009Date of Patent: August 7, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Zhi-Ying Chen, Mark A. Kay
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Patent number: 8124407Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: GrantFiled: January 13, 2011Date of Patent: February 28, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mark A. Kay, Zhi-Ying Chen
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Publication number: 20110244566Abstract: Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.Type: ApplicationFiled: February 1, 2011Publication date: October 6, 2011Inventors: Joseph Wu, Michael T. Longaker, Mark A. Kay, Ning Sung, FangJun Jia, Zhi-Ying Chen, Nicholas Panetta, Deepak Gupta
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Publication number: 20110126306Abstract: Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are to characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an expression cassette. Also provided are methods of using the subject vectors for introduction of a nucleic acid, e.g., an expression cassette, into a target cell, as well as preparations for use in practicing such methods. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications. Also provided is a highly efficient and readily scalable method for producing the vectors employed in the subject methods, as well as reagents and kits/systems for practicing the same.Type: ApplicationFiled: January 13, 2011Publication date: May 26, 2011Inventors: Mark A. Kay, Zhi-Ying Chen
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Publication number: 20110118333Abstract: Compositions and methods are provided for the treatment of an ischemic cardiovascular condition by providing a patient with a novel non-viral minicircle DNA vector comprising polynucleotide sequences that potentiate HIF-1 activity, including RNAi or antisense agents selective for proteins involved in HIF1 inactivation.Type: ApplicationFiled: October 22, 2010Publication date: May 19, 2011Inventors: Joseph Wu, Mark A. Kay, Mei Huang, Zhi-Ying Chen