Patents by Inventor Zhiguo Liu

Zhiguo Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230063711
    Abstract: A method for displaying item information includes: displaying by an audience terminal, category information corresponding to a combined item object and an interaction operation control on an item display interface of a live broadcast room, in which the interaction operation control is configured to view basic information of sub-item objects and the combined item object includes at least two sub-item objects of the same category; in response to a trigger operation of the interaction operation control, determining by the audience terminal, a target sub-item object matching specified geographic information of the audience terminal from the at least two sub-item objects; and displaying by the audience terminal, basic information corresponding to the target sub-item object on the item display interface.
    Type: Application
    Filed: April 4, 2022
    Publication date: March 2, 2023
    Inventors: Peng Liu, Zhiguo Liu, Haolei Yang, Yayun Zuo, Zhenhang Ning, Wei Gao, Kai Yang, Zhuai Wang, Jifeng Yao, Guangyuan Lu, Zhen Ma, Wei Ni
  • Publication number: 20230062272
    Abstract: Provided are compositions for simultaneously modifying amino acids of site 736 and site 738 of pAPN gene and application thereof. An sgRNA set specifically recognizing porcine pAPN gene can recognize sequences near amino acids of site 736 and site 738 of pAPN gene, and has strong specificity. On this basis, in combination with a composition consisting of a cleavage protein and a double-stranded donor sequence, simultaneous modification of amino acids of site 736 and site 738 of the pAPN gene can be realized. Under editing of the composition, the amino acids of site 736 and site 738 of the pAPN gene are modified precisely and effectively, which can prevent normal expression of other amino acids of the pAPN gene from being damaged or changed. Therefore, it can resist TGEV infection, and also can retain the physiological activity function of the pAPN protein to the maximum extent.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 2, 2023
    Inventors: Kui Li, Yulian Mu, Changjiang Xu, Zhiguo Liu
  • Publication number: 20230045776
    Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: February 25, 2021
    Publication date: February 9, 2023
    Applicant: Genentech, Inc.
    Inventors: Sharada Labadie, Jun Liang, Daniel Fred Ortwine, Xiaojing Wang, Jason Zbieg, Birong Zhang, Simon Charles Goodacre, Nicholas Charles Ray, Jun Li, Tommy Lai, Jiangpeng Liao, Zhiguo Liu, John Wai, Tao Wang
  • Patent number: 11575093
    Abstract: A method for enhancing the performance of pentacene organic field-effect transistor (OFET) using n-type semiconductor interlayer: an n-type semiconductor thin film was set between the insulating layer and the polymer electret in the OFET with the structure of gate-electrode/insulating layer/polymer/pentacene/source (drain) electrode. The thickness of n-type semiconductor layer is 1˜200 nm. The induced electrons at the interface of n-type semiconductor and polymer electret lead to the reduction of the height of the hole-barrier formed at the interface of polymer and pentacene, thus effectively reducing the programming/erasing (P/E) gate voltages of pentacene OFET, adjusting the height of hole barrier at the interface of polymer and pentacene to a reasonable scope by controlling the quantity of induced electrons in n-type semiconductor layer, thus improving the performance of pentacene OFET, such as the P/E speeds, P/E endurance and retention characteristics.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: February 7, 2023
    Assignee: NANJING UNIVERSITY
    Inventors: Limin Kang, Yiru Wang, Jiang Yin, Yidong Xia, Zhiguo Liu
  • Publication number: 20230002408
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: December 18, 2020
    Publication date: January 5, 2023
    Inventors: Gang DENG, Zhanling CHENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yimin JIANG, Yanping XU
  • Publication number: 20220281865
    Abstract: Provided herein are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Inventors: Yimin JIANG, Zhanling CHENG, Gang DENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yanping XU
  • Publication number: 20220267313
    Abstract: Provided herein are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: July 30, 2020
    Publication date: August 25, 2022
    Inventors: Yimin JIANG, Zhanling CHENG, Gang DENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yanping XU
  • Publication number: 20220081423
    Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain.
    Type: Application
    Filed: May 26, 2021
    Publication date: March 17, 2022
    Applicant: GENENTECH, INC.
    Inventors: Daniel SUTHERLIN, Steven MCKERRALL, Kwong Wah LAI, Zhiguo LIU, Wenfeng LIU, Ramsay BEVERIDGE, Jean-Philippe LECLERC, Alexandre LEMIRE, Liang ZHAO, Claudio STURINO
  • Publication number: 20220069244
    Abstract: A method for enhancing the performance of pentacene organic field-effect transistor (OFET) using n-type semiconductor interlayer: an n-type semiconductor thin film was set between the insulating layer and the polymer electret in the OFET with the structure of gate-electrode/insulating layer/polymer/pentacene/source (drain) electrode. The thickness of n-type semiconductor layer is 1˜200 nm. The induced electrons at the interface of n-type semiconductor and polymer electret lead to the reduction of the height of the hole-barrier formed at the interface of polymer and pentacene, thus effectively reducing the programming/erasing (P/E) gate voltages of pentacene OFET, adjusting the height of hole barrier at the interface of polymer and pentacene to a reasonable scope by controlling the quantity of induced electrons in n-type semiconductor layer, thus improving the performance of pentacene OFET, such as the P/E speeds, P/E endurance and retention characteristics.
    Type: Application
    Filed: November 24, 2020
    Publication date: March 3, 2022
    Applicant: Nanjing University
    Inventors: Limin Kang, Yiru WANG, Jiang YIN, Yidong Xia, Zhiguo LIU
  • Patent number: 11265077
    Abstract: Disclosed is a method for deploying tasks in a satellite network. In the method for deploying tasks in a satellite network, a utility function is determined by constructing a task processing delay model and a traffic model; a fitness degree of each individual is determined according to the utility function, and an individual with a highest fitness degree is put into a next-generation population; a probability that each of the plurality of individuals is selected is determined according to the fitness degree; a crossover operation and a mutation operation are performed on the individual according to the probability, to obtain a crossover individual and a mutation individual respectively; an available crossover individual and an available mutation individual are put into a next-generation population, to perform a repeated iteration and complete population updating; an optimal task deployment location table is output; and satellite network task deployment is completed.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: March 1, 2022
    Assignee: Dalian University
    Inventors: Zhiguo Liu, Yunqi Li, Jianxin Feng, Chengsheng Pan
  • Publication number: 20220053143
    Abstract: A user may select an image of a scene captured by a mobile device as a reference image. The mobile device may present the reference image as a translucent background image on a display of the mobile device, and may display a preview image of the scene over the translucent background image so that the user can adjust a position and/or an orientation of the mobile device until the preview image is aligned with the translucent background image. In some aspects, the mobile device may determine a similarity value between the preview image and the translucent background image, and may present the similarity value on the display.
    Type: Application
    Filed: December 28, 2018
    Publication date: February 17, 2022
    Inventors: Zhiguo LIU, Nan ZHANG, Yongjun XU, Zhe LI
  • Patent number: 11240997
    Abstract: Provided is a double-gene knockout vector system, a method for preparing porcine fibroblasts with both CD163 gene and CD13 gene being knocked-out, prepared porcine fibroblasts, and a method for preparing a gene-edited pig with both CD163 gene and CD13 gene being knocked-out. The vector system of the present disclosure comprises a CD163 gene knockout vector and a CD13 gene knockout vector. The CD163 gene knockout vector comprises a gene editing vector backbone and a DNA fragment ligated to the gene editing vector backbone, with a nucleotide sequence of the DNA fragment being shown in any one of SEQ ID NOs: 1-3. The CD13 gene knockout vector comprises a gene editing vector backbone and a DNA fragment ligated to the gene editing vector backbone, a nucleotide sequence of the DNA fragment being shown in any one of SEQ ID NOs: 4-6.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 8, 2022
    Assignee: Shandong Landsee Genetics Co., Ltd.
    Inventors: Kui Li, Yulian Mu, Zhiguo Liu, Julang Li, Kui Xu, Yinghui Wei, Changli Ge, Xuehui Cai, Long Wang, Qimei Chen, Yang Qiu
  • Publication number: 20220013739
    Abstract: A method for enhancing the performance of pentacene organic field-effect transistor (OFET): an n-type semiconductor thin film was set as a buffer layer between pentacene and polymer electret in the OFET with the structure of gate-electrode/insulating layer/polymer/pentacene/source (drain) electrode. The thickness of n-type organic buffer layer is 1˜100 nm. The induced electrons at the interface lead to the reduction of the height of the hole-barrier formed at the interface, thus effectively reducing the programming/erasing (P/E) gate voltages of pentacene OFET. The widened distribution region of positive space charges caused by ionized donors in n-type organic buffer layer effectively restricts the back-transfer of holes from polymer to pentacene, thus improving the performance of pentacene OFET, such as the P/E speeds, P/E endurance and retention characteristics.
    Type: Application
    Filed: July 29, 2020
    Publication date: January 13, 2022
    Applicant: Nanjing University
    Inventors: Limin Kang, Yiru WANG, Jiang YIN, Yidong Xia, Zhiguo LIU
  • Publication number: 20210277051
    Abstract: The invention relates to a compound or a salt thereof, a method for preparation thereof, and use thereof, wherein the compound has the structure of Formula (1): the substituents in Formula (1) are as defined in the specification. The compound of Formula (1) or a salt thereof can be attached to a solid-phase resin, on which solid-phase synthesis may be performed.
    Type: Application
    Filed: June 22, 2018
    Publication date: September 9, 2021
    Inventors: Haiying XING, Zhiguo LIU, Xinyou YU, Xiaohang CHEN, Huiping WANG
  • Patent number: 11098513
    Abstract: A door-and-window system having a handle component (121), a transmission component (123) and a force receiving portion (12231). When the handle component (121) is operated, the force receiving portion (12231) moves along a first guide groove (12211) via the transmission component (123), and at the same time a driving portion (12232) moves along a second guide groove (12221). Due to a relationship between a guide member (1224) and a third guide groove (12212), a first base seat (1221) translates relative to a second base seat (1222) along a direction of the third guide groove (12212), such that a movable door-and-window (11) can abut tightly against or move away from a sealing member (24) on a door-and-window mounting profile (2).
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: August 24, 2021
    Assignee: Shenzhen Hopo Window Control Technology Co., Ltd.
    Inventors: Zhiguo Liu, Zhou Lin
  • Publication number: 20210236473
    Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: February 25, 2021
    Publication date: August 5, 2021
    Applicant: Genentech, Inc.
    Inventors: Sharada Labadie, Jun Liang, Daniel Fred Ortwine, Xiaojing Wang, Jason Zbieg, Birong Zhang, Simon Charles Goodacre, Nicholas Charles Ray, Jun Li, Tommy Lai, Jiangpeng Liao, Zhiguo Liu, John Wai, Tao Wang
  • Patent number: 11041587
    Abstract: An ultraviolet curing pipeline repair robot is provided. The ultraviolet radiation lamp comprises a lamp panel distributed at the circumference of frame body and ultraviolet LED lamps uniformly distributed on the lamp panel. Each frame body is provided with a spring sleeve circumferentially rotating around frame body. Each driving arm is formed by cross connection of two supporting arms. One end of the first supporting arm is fixedly arranged on frame body, one end of the second supporting arm is connected with a driving arm nut, and the driving arm nut is sleeved the spring sleeve and matched with the screw thread on the outer surface of the spring sleeve. The inside of a tail section of frame body is provided with a network transmission module and a first power carrier module connected with a second aviation plug. A cable is a power cable.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: June 22, 2021
    Assignee: WUHAN EASY-SIGHT TECHNOLOGY CO., LTD.
    Inventors: Zhiguo Liu, Yanlei Lu, Jia Yu, Xiang Wang, Wanjia Zhang, Hao Li
  • Patent number: 11034698
    Abstract: Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: June 15, 2021
    Assignee: Genentech, Inc.
    Inventors: Marian C. Bryan, Steven Do, Joy Drobnick, Alberto Gobbi, Tamiko Katsumoto, James Richard Kiefer, Jr., Jun Liang, Naomi S. Rajapaksa, Yongsheng Chen, Liqiang Fu, Kwong Wah Lai, Zhiguo Liu, John Wai, Fei Wang
  • Publication number: 20210171516
    Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Application
    Filed: September 24, 2020
    Publication date: June 10, 2021
    Applicants: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Philippe BERGERON, Kristen BURFORD, Sultan CHOWDHURY, Christoph Martin DEHNHARDT, Thilo FOCKEN, Michael Edward GRIMWOOD, Abid HASAN, Kwong Wah LAI, Zhiguo LIU, Steven MCKERRALL, Teresa Phuongtram NGUYEN, Brian Salvatore SAFINA, Daniel SUTHERLIN, Tao WANG
  • Patent number: 11028075
    Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 8, 2021
    Assignee: Genentech, Inc.
    Inventors: Daniel Sutherlin, Steven McKerrall, Kwong Wah Lai, Zhiguo Liu, Wenfeng Liu, Ramsay Beveridge, Jean-Philippe Leclerc, Alexandre Lemire, Liang Zhao, Claudio Sturino