Patents by Inventor Zhihai Qiu

Zhihai Qiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for optogenetics experiments
    Patent number: 11633620
    Abstract: A method for optogenetics experiments, based on wavefront shaping and including: calculating the transmission matrix between an input end and an output end of the multimode fiber under a fixed shape; implanting the output end into an intracranial space of an experimental subject; and performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: April 25, 2023
    Assignee: THE HONG KONG POLYTECHNIC UNIVERSITY SHENZHEN RESEARCH INSTITUTE
    Inventors: Puxiang Lai, Lei Sun, Tianting Zhong, Zhihai Qiu
  • METHOD AND SYSTEM FOR OPTOGENETICS EXPERIMENTS
    Publication number: 20210154489
    Abstract: A method for optogenetics experiments, based on wavefront shaping and including: calculating the transmission matrix between an input end and an output end of the multimode fiber under a fixed shape; implanting the output end into an intracranial space of an experimental subject; and performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.
    Type: Application
    Filed: April 8, 2020
    Publication date: May 27, 2021
    Inventors: Puxiang LAI, Lei SUN, Tianting ZHONG, Zhihai QIU
  • Enhanced Selective Cellular Stimulation by Ultrasound
    Publication number: 20200069801
    Abstract: There is provided a method of sensitising a eukaryotic cell to ultrasound stimulation, said method comprising increasing the mechano-sensitivity of a transmembrane ion channel of the cell to ultrasound by introducing a plurality of entire exogenous gas vesicles proximal to the surface of the cell.
    Type: Application
    Filed: August 29, 2018
    Publication date: March 5, 2020
    Applicant: The Hong Kong Polytechnic University
    Inventors: Lei SUN, Zhihai QIU, Jinghui GUO
  • A NON-INVASIVE METHOD FOR SELECTIVE NEURAL STIMULATION BY ULTRASOUND
    Publication number: 20190308035
    Abstract: In an aspect of the present disclosure there is provided a method for reversibly stimulating neuronal cells, said method comprising activating mechanosensitive ion channels of neuronal cells expressing said channels by exposing said cells to an ultrasound stimulus.
    Type: Application
    Filed: April 10, 2018
    Publication date: October 10, 2019
    Inventors: Lei Sun, Zhihai Qiu, Yaoheng Yang, Jinghui Guo, Shashwati Kala, Jiejun Zhu
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110257137
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 10, 2011
    Publication date: October 20, 2011
    Applicant: KALYPSYS, INC.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Becker, Daniel Gamache, Stewart A. Noble, Mark Hellberg, Peter Klimko, Zhihai Qiu, Joseph Payne, John Yanni