Abstract: Provided is a confined migration microfluidic device for cell culture and drug screening, including a chip including a plurality of parallel channels, where each pair of it is connected through a plurality of the confined migration channels; a depth of the confined migration channel is lower than the first channel and second channel; a first/second inlet and a first/second outlet are provided at two ends of the first/second channel, respectively; and a pyramid-like structure for diverging flow to the first channels to ensure evenly distribution. During the usage, cells to be cultured are added into one of the first channel and the second channel, and drugs or cells which can influence confined migration of the target cells are added into the other channel; the inhibitory effect of the drugs or cells on the confined migration will be evaluated, thereby screening/studying effective drugs and cells in relation to the confined migration.

Abstract: Disclosed by the present invention is a target pipeline dynamic thermal failure analysis method in a parallel pipeline jet fire scenario, including the following steps: 1, inputting operation parameters of source pipeline to obtain instantaneous thermal radiation value received by target pipeline in instantaneous jet fire near field; 2, establishing fitting function relational expression of the instantaneous thermal radiation value and time change; 3, calculating instantaneous temperature distribution result of the pipe wall of the target pipeline; 4, calculating convective heat transfer coefficient of inner wall of the target pipeline; 5, calculating instantaneous thermal stress and total instantaneous stress borne by the pipe wall of the target pipeline in a circumferential direction, radial direction and axial direction; 6, carrying out testing to obtain yield strength and ultimate tensile strength corresponding to different temperatures; and 7, analyzing and judging target pipeline dynamic failure result.