Abstract: Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.

Abstract: An on-site reciprocity calibration method for a piezoelectric accelerometer, including a vibration test and a reciprocity test. In the vibration test, a sine excitation with a corresponding frequency and amplitude is provided by a vibration exciting device to the piezoelectric accelerometer fixed on a motion plane, and output signals of a drive port and a signal port of the reciprocal piezoelectric accelerometer are collected by a data acquisition device. In the reciprocity test, a sine voltage excitation is provided by a signal generator to the drive port, and then an excitation signal and an output signal of the signal port are collected by the data acquisition device. An amplitude ratio of the two signals is obtained based on signal sine-fitting. Finally, the on-site calibration is enabled according the sensitivity amplitude ratio obtained in the vibration test and the sensitivity amplitude product obtained in the reciprocity test.

Abstract: A flexible electronic sensor array apparatus comprising: a continuous flexible sheet having a length defining a first axis, a width defining a second axis and a thickness comprising a third axis; wherein the flexible sheet comprises multiple flexible sheet layers formed of one or more flexible materials stacked along the third axis; a plurality of electronic sensors disposed within the flexible sheet, each respective sensor comprising at least two conductive pattern layers, the two conductive pattern layers of the respective sensor spaced apart from one another along the third axis by one of the flexible sheet layers interposed between the conductive pattern layers; and wherein each respective sensor of the plurality of sensors is disposed at a different respective position along the first axis or the second axis of the flexible sheet from the remaining sensors, thereby forming an array of sensors spaced along the first and second axes.

Abstract: A three-dimensional thermistor device and a manufacturing method thereof. The three-dimensional thermistor device comprising a thermistor array formed on a base layer extending in first and second directions. Where the thermistor array comprises: thermistor pattern layers and insulating layers stacked alternately on the base layer in a third direction; each thermistor pattern layer including a continuous electrically conductive first trace disposed along a first path extending in both the first and second directions, and each insulating layer including an electrically conductive first via extending through the insulating layer in the third direction to electrically connect the first traces to each other.

Abstract: A three-dimensional thermistor device and a manufacturing method thereof. The three-dimensional thermistor device comprising a thermistor array formed on a base layer extending in first and second directions. Where the thermistor array comprises: thermistor pattern layers and insulating layers stacked alternately on the base layer in a third direction; each thermistor pattern layer including a continuous electrically conductive first trace disposed along a first path extending in both the first and second directions, and each insulating layer including an electrically conductive first via extending through the insulating layer in the third direction to electrically connect the first traces to each other.

Abstract: A flexible electronic sensor array apparatus comprising: a continuous flexible sheet having a length defining a first axis, a width defining a second axis and a thickness comprising a third axis; wherein the flexible sheet comprises multiple flexible sheet layers formed of one or more flexible materials stacked along the third axis; a plurality of electronic sensors disposed within the flexible sheet, each respective sensor comprising at least two conductive pattern layers, the two conductive pattern layers of the respective sensor spaced apart from one another along the third axis by one of the flexible sheet layers interposed between the conductive pattern layers; and wherein each respective sensor of the plurality of sensors is disposed at a different respective position along the first axis or the second axis of the flexible sheet from the remaining sensors, thereby forming an array of sensors spaced along the first and second axes.

Abstract: A flexible electronic sensor array apparatus comprising: a continuous flexible sheet having a length defining a first axis, a width defining a second axis and a thickness comprising a third axis; wherein the flexible sheet comprises multiple flexible sheet layers formed of one or more flexible materials stacked along the third axis; a plurality of electronic sensors disposed within the flexible sheet, each respective sensor comprising at least two conductive pattern layers, the two conductive pattern layers of the respective sensor spaced apart from one another along the third axis by one of the flexible sheet layers interposed between the conductive pattern layers; and wherein each respective sensor of the plurality of sensors is disposed at a different respective position along the first axis or the second axis of the flexible sheet from the remaining sensors, thereby forming an array of sensors spaced along the first and second axes.

Abstract: A three-dimensional thermistor device and a manufacturing method thereof. The three-dimensional thermistor device comprising a thermistor array formed on a base layer extending in first and second directions. Where the thermistor array comprises: thermistor pattern layers and insulating layers stacked alternately on the base layer in a third direction; each thermistor pattern layer including a continuous electrically conductive first trace disposed along a first path extending in both the first and second directions, and each insulating layer including an electrically conductive first via extending through the insulating layer in the third direction to electrically connect the first traces to each other.

Abstract: A molded door skin with integral divided light bars. The divided light bars are either true divided light (TDL) bars simulated divided light (SDL) bars or decorative grilles. The door skin includes a body portion and a divided light bar portion. The body portion and divided light bar portion are of one-piece construction which is preferably compression molded from fiberglass or other synthetic materials. Once assembled into a door with door glass installed, the divided light bars form a number of small windows for either simulating the appearance of traditional divided light windows in SDL applications, holding individual panes of insulating glass units in TDL applications, or for decorative purpose only.

Abstract: An integral plastic true divide light (TDL) window frame to replace wood true divided light window frame and grilles which are composed of individual pieces of wood frames and grilles joined together chemically or mechanically. The integral plastic TDL window frame is preferably of one-piece molded plastic construction with a number of small windows for holding individual panes of insulating glass units (lights, preferably with beveled glass), and consequently the window frame and muntin grilles form an inseparable integrated unit.

Abstract: A hybrid fiberglass wood door has a first fiberglass skin; a second fiberglass skin, and an internal wood block disposed therebetween. A wood veneer is attached to an outer surface of the second fiberglass skin. A first glass stop is connected to the first fiberglass skin and a second glass stop is connected to the internal wood block. A glass pane is secured between the first and the second glass stops.

Abstract: A wood-fiberglass hybrid panel door featuring natural wood veneer permanently bonded to at least one side of a fiberglass door. The panel and the stile/rail portions of the fiberglass door skin for bonding wood veneers can be either one-piece compression molded construction or can be separately compression molded pieces joined together by mechanical or chemical methods. The two pieces of door skins are used to make a fiberglass door first. Wood veneer is then bonded to at least one side of the said fiberglass door through the use of a vacuum press. Wood raised molding or flush sticking is applied around the veneered panel to cover the veneer edges on the panel and/or stiles/rails. Wood raised molding or flush sticking is fixed to the door by mechanical or chemical methods.

Abstract: A wood-fiberglass hybrid panel door featuring natural wood veneer permanently bonded to at least one side of a fiberglass door. The panel and the stile/rail portions of the fiberglass door skin for bonding wood veneers can be either one-piece compression molded construction or can be separately compression molded pieces joined together by mechanical or chemical methods. The two pieces of door skins are used to make a fiberglass door first. Wood veneer is then bonded to at least one side of the said fiberglass door through the use of a vacuum press. Wood raised molding or flush sticking is applied around the veneered panel to cover the veneer edges on the panel and/or stiles/rails. Wood raised molding or flush sticking is fixed to the door by mechanical or chemical methods.

Abstract: A cartridge for use with a mounting head for the preparation of fluid comestibles comprising a cartridge inlet, a chamber connected to said cartridge inlet for containing suitable flavor-containing or particle materials, a cartridge outlet connected to said chamber and a handle enabling a user to hold the handle to attach and secure the cartridge inlet to the mounting head to allow the liquid to be delivered under pressure through the flavor-containing or particle materials in the chamber, through the cartridge outlet and directly into a receptacle such as a cup or carafe for consumption, thereby dramatically simplifying the preparation of the fluid comestibles and relieving the user from the tedious cleaning work. The handle comprising at least part of the wall of the chamber, which is sufficiently rigid.

Abstract: An applicator for applying fluid or paste product to hair or hair-like objects on a surface comprises a handle, an application member for holding an amount of product and applying the product to the objects, and a shield for covering at least part of the application member to prevent the surface from contacting the application member during the use of the applicator, thereby preventing the surface from being contaminated by the product. The shield has at least one opening configured to allow the hair or hair-like objects to reach the product on the application member, thereby causing the objects to be coated by the product. A product loading system is used to load an amount of product selectively to the application member while leaving the shield substantially free of the product. The loading system has a dosage indicator for showing the user how much product is used for a particular application and a level indicator for showing the user how much product is left.

Abstract: A cartridge for use with a mounting head for the preparation of fluid comestibles comprising a cartridge inlet, a chamber connected to said cartridge inlet for containing suitable flavor-containing or particle materials, a cartridge outlet connected to said chamber and a handle enabling a user to hold the handle to attach and secure the cartridge inlet to the mounting head to allow the liquid to be delivered under pressure through the flavor-containing or particle materials in the chamber, through the cartridge outlet and directly into a receptacle such as a cup or carafe for consumption, thereby dramatically simplifying the preparation of the fluid comestibles and relieving the user from the tedious cleaning work. The handle comprising at least part of the wall of the chamber, which is sufficiently rigid.

Abstract: A cooktop hygiene device removably mountable to a cooktop for collecting food sputterings or spillings and preventing such sputterings or spillings from contaminating the cooktop comprises a plate-like structure, which can be flexible or rigid, having an upper surface adapted to receive the spillings or sputterings and a lower surface adapted to interface with the cooktop surface, and a plurality of openings on the plate-like structure to receive the heaters on the cooktop and to allow a user to place a cookware or utensil on the heaters. A fold facilitator is provided on the plate like structure to facilitate the folding of the device to fit into a dishwasher. A plurality of drip pans secured to the plate-like structure is provided for catching the food and liquid spillings or sputterings. The plurality of openings may be covered by heater covers to provide cooking zones on the plate-like structure to engage with the heaters and conduct heat from the heaters to cookware on the cooking zones.

Abstract: An apparatus and methods for making drinks such as cappuccino, latte, espresso, coffee or filtered water which comprise a cold water filter system for purifying water for either direct consumption or use in extracting flavor-containing materials like coffee, a hot water filter assembly located on the brew head for removing impurities originated from both water itself and the parts of the apparatus in contact with water, and/or an automatic milk frothier for frothing the milk. The cold water filter system comprises a removable water container having at its bottom a water flow passageway, a filter cartridge removably mounted in the water flow passageway, a containing chamber for receiving filtered water, and a valve in the water flow passageway for automatically closing the passageway when the container is removed from and opening the passageway when placed onto the chamber.

Abstract: An improved espresso/cappuccino machine and methods which comprise a crema device downstream of the coffee filter for producing consistent and rich crema on top of the espresso and an automatic milk frothier for producing a predetermined amount of visually appealing foamy head for the milk, both in a manner that is independent of the operators' skill. The crema device comprises an expandable opening for forming a stream or jet of espresso, a crema chamber having keeping means for maintaining an amount of espresso in the chamber during the brewing process, and an arrangement that allows the jet of espresso to plunge directly into the espresso maintained in the chamber thereby producing the crema.

Abstract: An apparatus for automatically brewing coffee, tea, or the like comprises a cell for automatically drawing a predetermined amount of water from a water reservoir. A heating unit heats the water in the cell up to boiling and subsequently generates pressurized steam in the cell. The heated water in the cell is forced out of the outlet, which is positioned at the lowest portion of the cell, and delivered under the pressure of the pressurized steam to and through the coffee grounds, tea, or the like in a container. The pressurized steam is released into atmosphere by a valve means before it reaches the coffee grounds, tea, or the like in the container in one embodiment of the present invention and it passes through and drys the wet coffee grounds, tea, or the like in the container in the other embodiment.