Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives.

Abstract: A transient electromagnetic device with variable shape and turns includes squares, a transmitting coil carrying frame, a transmitting coil, a turns-variable device, a current generator and a working power supply. The transmitting coil carrying frame is arranged inside the transmitting coil; the transmitting coil carrying frame is configured as a carrier of the transmitting coil, and configured for adjusting a side length of the transmitting coil and a shape of the transmitting coil; the square is configured for clamping and connecting the transmitting coil and the transmitting coil carrying frame to fix the transmitting coil to the transmitting coil carrying frame. The current generator is configured for generating transient current; the turns-variable device is configured for changing the turns of the transmitting coil; and the transmitting coil is configured for transmitting the transient current to a target area to be measured.

Abstract: A class of pyrimidoheterocyclic compounds, and specifically disclosed is a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

Abstract: Provided are a tandem epitope polypeptide vaccine for novel coronavirus and use thereof. Specifically, a vaccine polypeptide for novel coronavirus pneumonia is provided on the basis of analysis and study of the RBD sequence and structural information of the S protein of SARS-CoV-2. Said vaccine polypeptide comprises the following elements connected in series: a generic Th epitope sequence, a B cell epitope sequence and a T cell epitope sequence. The B cell epitope and the T cell epitope have an amino acid sequence from the RBM region of the S protein of SARS-CoV-2. Provided are a vaccine composition containing said vaccine polypeptide and use thereof. Experiments show that the vaccine polypeptide of the present invention can enable cynomolgus monkeys to initiate strong cellular and humoral immunity, and to generate neutralizing antibodies that block the binding of RBD and ACE2, and can be used for preventing and treating novel coronavirus pneumonia.

Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: A method for predictive caching may include determining previous user activity related to data items and/or documents, receiving a request to view a document from a user, predicting data items to pre-cache based on the previous user activity and at least one other factor, prioritizing the predicted data items for pre-caching, dividing the prioritized data items for pre-caching into a plurality of groups, downloading prioritized data items for each group among the plurality of groups according to the prioritization of the predicted data items, and displaying a view of the document after data items, corresponding to the request, are received.

Abstract: The present disclosure relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with zolinium(s) shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.

Abstract: In one embodiment, a method is provided. The method includes selecting, with a communications management system, a first satellite communications (SATCOM) system of a plurality of SATCOM systems as a primary SATCOM system based on user input, received by a human machine interface, that identifies the first SATCOM system as a user-selected SATCOM system. The method further includes automatically switching, with the communications management system, the primary SATCOM system from the first SATCOM system to a second SATCOM system of the plurality of SATCOM systems in response to: a fault status for the first SATCOM system; a loss of channel availability for the first SATCOM system; and/or a failed datalink message transmission for the first SATCOM system. The method further includes establishing a communication link between the primary SATCOM system and a ground station.

Abstract: A method for predictive caching may include determining previous user activity related to data items and/or documents, receiving a request to view a document from a user, predicting data items to pre-cache based on the previous user activity and at least one other factor, prioritizing the predicted data items for pre-caching, dividing the prioritized data items for pre-caching into a plurality of groups, downloading prioritized data items for each group among the plurality of groups according to the prioritization of the predicted data items, and displaying a view of the document after data items, corresponding to the request, are received.

Abstract: In one embodiment, a method is provided. The method includes selecting, with a communications management system, a first satellite communications (SATCOM) system of a plurality of SATCOM systems as a primary SATCOM system based on user input, received by a human machine interface, that identifies the first SATCOM system as a user-selected SATCOM system. The method further includes automatically switching, with the communications management system, the primary SATCOM system from the first SATCOM system to a second SATCOM system of the plurality of SATCOM systems in response to: a fault status for the first SATCOM system; a loss of channel availability for the first SATCOM system; and/or a failed datalink message transmission for the first SATCOM system. The method further includes establishing a communication link between the primary SATCOM system and a ground station.

Abstract: Disclosed is a Glechoma longituba (Nakai) Kupr. extract, specifically compounds I and II, a preparation method for same, and a use thereof in preparing a medicament for blood glucose decease, blood lipids decrease, weight loss, and kidney disease treatment or a method for treatment of said diseases, and a composition containing the extract.

Abstract: Disclosed is a Glechoma longituba (Nakai) Kupr. extract, specifically compounds I and II, a preparation method for same, and a use thereof in preparing a medicament for blood glucose decease, blood lipids decrease, weight loss, and kidney disease treatment or a method for treatment of said diseases, and a composition containing the extract.

Abstract: Example methods, apparatus and articles of manufacture to monitor communication paths in communication systems are disclosed. An example method includes identifying links of a communication system, the links communicatively coupling router pairs, identifying communication paths in the communication system, each of the communication paths being routed via one or more of the links, testing the links during a first interval by testing at least a first portion of the communication paths, testing the links during the second interval by testing at least a second portion of the communication paths, changing the first portion of the communication paths to include at least one of the communication paths from the second portion of the communication paths such that testing the first portion of the communication paths and testing the second portion of the communication paths collectively test each of the links, and identifying a link failure based on the testing.