Abstract: Apparatuses, systems, and techniques to perform a cryptographic operation using multiple iterations, wherein each iteration includes two or more stages operating in parallel on inputs derived from a common value, one of the stages computing real data and other stages computing dummy data.

Abstract: Provided herein includes a method for characterizing a target cell-free nucleic acid (cfNA) molecule present in a biological sample such as a urine sample. It comprises isolating total cfNAs from the biological sample without prior preprocessing such as centrifugation to remove cell debris, and characterizing the target cfNA molecule based on the isolated total cfNAs. When the target cfNA is a low molecular weight (LMW) molecule, the method additionally comprises a fractionation step to obtain LMW nucleic acids from the total cfNAs before characterization. The method can detect significantly more copies of the target cfNA molecule compared with existing methods which typically discard the cell debris from the biological sample. Another method is also provided, which substantially recovers cfNAs from the usually discarded cell debris, thus also capable of detecting significantly more copies of the target cfNA molecule.

Abstract: The present invention includes a voltage controlled oscillator circuit and a phase-locked loop device. The voltage controlled oscillator circuit comprises: a voltage-to-current conversion module, used for converting a control voltage of a voltage controlled oscillator into a control current as a linear function of the control voltage; and a current controlled oscillation module, used for outputting a low-amplitude oscillation signal based on the control current, so as to reduce power consumption. Further provided in the present invention is a phase-locked loop device comprising the voltage controlled oscillator circuit. According to the voltage controlled oscillator circuit, design parameters of low power consumption and high linearity may be achieved, thereby making a gain Kvco of the voltage controlled oscillator relatively stable, and it may be ensured that the voltage controlled oscillator and the phase-locked loop comprising the same have relatively excellent device performance.

Abstract: The present invention includes a voltage controlled oscillator circuit and a phase-locked loop device. The voltage controlled oscillator circuit comprises: a voltage-to-current conversion module, used for converting a control voltage of a voltage controlled oscillator into a control current as a linear function of the control voltage; and a current controlled oscillation module, used for outputting a low-amplitude oscillation signal based on the control current, so as to reduce power consumption. Further provided in the present invention is a phase-locked loop device comprising the voltage controlled oscillator circuit. According to the voltage controlled oscillator circuit, design parameters of low power consumption and high linearity may be achieved, thereby making a gain Kvco of the voltage controlled oscillator relatively stable, and it may be ensured that the voltage controlled oscillator and the phase-locked loop comprising the same have relatively excellent device performance.

Abstract: An oscillator comprising an RC oscillator and a bandgap reference source, wherein the bandgap reference source provides a reference current for the RC oscillator, and a temperature coefficient of the reference current is adjustable. Since the oscillation frequency of the RC oscillator has less dependency on a power supply, a clock source having a relatively precise frequency thus can be obtained; and based on the RC oscillator, the bandgap reference source having a temperature compensation function is added, the reference current generated by the bandgap reference source with an adjustable temperature coefficient is used for temperature coefficient compensation to the inherent temperature coefficient of the oscillation frequency of the RC oscillator, thereby reducing the effect of the temperature on the oscillator, so that the output frequency of the oscillator does not change with the temperature as far as possible, which improves the oscillation frequency precision of the oscillator.

Abstract: An oscillator comprising an RC oscillator and a bandgap reference source, wherein the bandgap reference source provides a reference current for the RC oscillator, and a temperature coefficient of the reference current is adjustable. Since the oscillation frequency of the RC oscillator has less dependency on a power supply, a clock source having a relatively precise frequency thus can be obtained; and based on the RC oscillator, the bandgap reference source having a temperature compensation function is added, the reference current generated by the bandgap reference source with an adjustable temperature coefficient is used for temperature coefficient compensation to the inherent temperature coefficient of the oscillation frequency of the RC oscillator, thereby reducing the effect of the temperature on the oscillator, so that the output frequency of the oscillator does not change with the temperature as far as possible, which improves the oscillation frequency precision of the oscillator.

Abstract: The present invention discloses a voltage-controlled oscillator (VCO) circuit, When the VCO circuit works, the DC control voltage is divided into two portions, both of which determine an oscillation frequency of the VCO circuit. One portion of the DC control voltage controls a current provided by the fifth PMOS transistor, and the other portion of the DC control voltage controls the current of the forth PMOS transistor after passing through the third NMOS transistor, thereby controlling oscillation of the VCO circuit. The former plays a leading role when the DC control voltage is relatively low, and the latter plays a leading role when the DC control voltage is relatively high, thereby effectively increasing the use range of the DC control voltage while the high frequency noise interference on the DC control voltage is suppressed. The present invention further discloses a phase-locked loop circuit.

Abstract: The invention provides a positive/negative phase shift bimetallic zone plate and production method thereof, wherein the positive/negative phase shift bimetallic zone plate comprises: a first metallic material having a positive phase shift; a second metallic material having a negative phase shift at a working energy point; wherein the first metallic material and the second metallic material are alternately arranged, so that the second metallic material replaces the blank portion in a cycle of a traditional zone plate.

Abstract: The invention provides a positive/negative phase shift bimetallic zone plate and production method thereof, wherein the positive/negative phase shift bimetallic zone plate comprises: a first metallic material having a positive phase shift; a second metallic material having a negative phase shift at a working energy point; wherein the first metallic material and the second metallic material are alternately arranged, so that the second metallic material replaces the blank portion in a cycle of a traditional zone plate.

Abstract: A hard X-ray grating phase-contrast imaging apparatus with large field-of-view, high contrast and low dose and the method thereof. The apparatus includes a source emitter (31), a source grating (G0), a beam splitting grating (G1), an analyzer grating (G2) and a detector (32) arranged in sequence on a transmission path of the source emitter (31). The beam splitting grating (G1) has a period of 30 to 50 ?m and a depth to width ratio not greater than 20. The apparatus can provide a high image contrast and a low radiation dose and realize a phase-contrast imaging with high energy and a large field-of-view by increasing the grating period, increasing a duty cycle of the beam splitting grating while increasing the distance between an object and the analyzer grating. The apparatus can also utilize the conventional polychromatic X-ray sources and available process for manufacturing gratings, and be suitable for clinical use.

Abstract: A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., DNA) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in the presence of a buffer which promotes binding of the high molecular weight urine nucleic acid to the adsorbent, replacing the buffer which promotes binding of the high molecular weight urine nucleic acid with a buffer which promotes binding of the low molecular weight urine nucleic acid to the adsorbent, extracting the low molecular weight urine nucleic acid by contacting with the adsorbent, eluting the low molecular weight urine nucleic acid, and assaying the low molecular weight urine nucleic acid for a presence or absence of a gene sequence specific to a certain type of tumor.

Abstract: A method of treating Type II diabetes utilizing two off-the-shelf drugs. Intravenous injection of one or both drugs, individually and in combination, can prevent and treat diabetes, restore damaged islet cell functions and reduce or stop the use of oral hypoglycemic agents and insulin.

Abstract: A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., DNA) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in the presence of a buffer which promotes binding of the high molecular weight urine nucleic acid to the adsorbent, replacing the buffer which promotes binding of the high molecular weight urine nucleic acid with a buffer which promotes binding of the low molecular weight urine nucleic acid to the adsorbent, extracting the low molecular weight urine nucleic acid by contacting with the adsorbent, eluting the low molecular weight urine nucleic acid, and assaying the low molecular weight urine nucleic acid for a presence or absence of a gene sequence specific to a certain type of tumor.