Patents by Inventor Zhimin Shi

Zhimin Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11299525
    Abstract: Provided is a chimeric antigen receptor-modified immune effector cell carrying a procedural death ligand 1 (PD-L1) blocking agent. Also provided is a method for secreting and expressing a PD-L1 blocking agent using the immune effector cell as a carrier to improve the anti-tumour effect of the chimeric antigen receptor-modified immune effector cell.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: April 12, 2022
    Assignee: CRAGE Medical Co., Limited
    Inventors: Zonghai Li, Zeyan Pan, Zhimin Shi, Bo Song, Peng Wang
  • Publication number: 20220011163
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Application
    Filed: July 19, 2021
    Publication date: January 13, 2022
    Applicants: The University of Rochester, University of South Florida
    Inventors: Zhimin Shi, Darrick Hay, Ziyi Zhu, Yiyu Zhou, Robert W. Boyd
  • Patent number: 11111295
    Abstract: Provided in the present invention is an antibody for anti-claudin 18A2 and an immune effector cell targeting claudin 18A2. Also provided are methods for inducing cell death and treating tumours.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: September 7, 2021
    Assignee: CAFA THERAPEUTICS LIMITED
    Inventors: Peng Wang, Hua Jiang, Linlin Yang, Zhimin Shi, Huamao Wang, Zonghai Li
  • Patent number: 11067450
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: July 20, 2021
    Assignee: University of South Florida
    Inventors: Zhimin Shi, Darrick Hay, Ziyi Zhu, Yiyu Zhou, Robert W. Boyd
  • Patent number: 10998981
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including at least the directional intensity complex amplitude and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: May 4, 2021
    Assignee: University of South Florida
    Inventor: Zhimin Shi
  • Publication number: 20210083775
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including at least the directional intensity complex amplitude and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Application
    Filed: February 28, 2020
    Publication date: March 18, 2021
    Applicant: University of South Florida
    Inventor: Zhimin Shi
  • Patent number: 10587345
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including at least the directional intensity complex amplitude, the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: March 10, 2020
    Assignee: University of South Florida
    Inventor: Zhimin Shi
  • Publication number: 20200062843
    Abstract: Disclosed are an anti-CD19 humanized antibody prepared from a murine monoclonal antibody, a chimeric antigen receptor containing the humanized antibody, and an immune cell expressing the humanized antibody. Not only does the humanized antibody of the present invention not produce an anti-antibody response (AAR) and a human anti-mouse antibody response (HAMA), but same also has better affinity than a murine antibody, and has excellent activity and safety, thereby providing a new means for treating CD19-expressing tumors.
    Type: Application
    Filed: December 13, 2017
    Publication date: February 27, 2020
    Inventors: Peng WANG, Huiping GAO, Zhimin SHI, Zonghai LI
  • Publication number: 20200011737
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Application
    Filed: May 6, 2019
    Publication date: January 9, 2020
    Applicants: The University of Rochester, University of South Florida
    Inventors: Zhimin Shi, Darrick Hay, Ziyi Zhu, Yiyu Zhou, Robert W. Boyd
  • Publication number: 20190393963
    Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including at least the directional intensity complex amplitude, the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
    Type: Application
    Filed: April 26, 2019
    Publication date: December 26, 2019
    Inventor: Zhimin Shi
  • Publication number: 20190233511
    Abstract: Provided in the present invention is an antibody for anti-claudin 18A2 and an immune effector cell targeting claudin 18A2. Also provided are methods for inducing cell death and treating tumours.
    Type: Application
    Filed: July 10, 2017
    Publication date: August 1, 2019
    Inventors: Peng WANG, Hua JIANG, Linlin YANG, Zhimin SHI, Huamao WANG, Zonghai LI
  • Publication number: 20180327470
    Abstract: Provided is a chimeric antigen receptor-modified immune effector cell carrying a procedural death ligand 1 (PD-L1) blocking agent. Also provided is a method for secreting and expressing a PD-L1 blocking agent using the immune effector cell as a carrier to improve the anti-tumour effect of the chimeric antigen receptor-modified immune effector cell.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 15, 2018
    Applicants: CARSGEN THERAPEUTICS CO., LTD., SHANGHAI CANCER INSTITUTE
    Inventors: Zonghai Li, Zeyan Pan, Zhimin Shi, Bo Song, Peng Wang
  • Patent number: 9500531
    Abstract: A wavefront sensing technique using Polarization Rotation INTerferometry (PRINT) provides a self-referencing, high-resolution, direct measurement of the spatially dependent phase profile of a given optical beam. A self-referencing technique is used to create a reference beam in the orthogonal polarization and a polarization measurement to measure the spatial-dependent polarization parameters to directly determine the absolute phase profile of the beam under test. A high-resolution direct measurement of the spatially-resolved phase profile of one or more optical beams is realized.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: November 22, 2016
    Assignee: University of Rochester
    Inventors: Zhimin Shi, Robert W. Boyd, Mohammad Mirhosseini, Mehul Malik
  • Publication number: 20140285813
    Abstract: A wavefront sensing technique using Polarization Rotation INTerferometry (PRINT) provides a self-referencing, high-resolution, direct measurement of the spatially dependent phase profile of a given optical beam. A self-referencing technique is used to create a reference beam in the orthogonal polarization and a polarization measurement to measure the spatial-dependent polarization parameters to directly determine the absolute phase profile of the beam under test. A high-resolution direct measurement of the spatially-resolved phase profile of one or more optical beams is realized.
    Type: Application
    Filed: March 25, 2014
    Publication date: September 25, 2014
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Zhimin Shi, Robert W. Boyd, Mohammad Mirhosseini, Mehul Malik
  • Patent number: 7990540
    Abstract: According to the invention, a highly optically dispersive medium is one in which the absolute value of the group index of refraction of the medium is equal to or greater than four. An optical spectroscopic parameter detection and/or measurement apparatus may be in the form of an interferometer, a spectral interferometer, a spectrometer, a wavemeter, a tunable narrowband filter The embodied devices include a highly dispersive medium that appropriately can facilitate either a slow-light effect or a fast-light effect, which is disposed in a propagation path of an electro-magnetic (EM) input field and, a detector disposed in a manner to detect an output field resulting from the input filed interaction with the highly dispersive medium. Methods involve measuring a spectroscopic parameter using an optical spectroscopic parameter detection and/or measurement apparatus that incorporates a highly dispersive medium.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: August 2, 2011
    Assignees: University of Rochester, Duke University
    Inventors: Robert W. Boyd, Daniel J. Gauthier, Zhimin Shi
  • Publication number: 20090073450
    Abstract: Embodiments of the invention pertain to the optical phenomena of ‘slow-light’ and ‘fast-light’, provided by a highly optically dispersive medium; that is, one in which the absolute value of the group index of refraction of the medium is equal to or greater than four. Apparatus embodiments of the invention are directed to an optical spectroscopic parameter detection and/or measurement apparatus. In various non-limiting aspects, the apparatus may be in the form of an interferometer, a spectral interferometer, a spectrometer, a wavemeter, a tunable narrowband filter, and other such devices. Various non-limiting, exemplary apparatus may include a two-beam interferometer, a multiple-beam interferometer, a grating-based interferometer/spectrometer, a Fourier-Transform interferometer, and others.
    Type: Application
    Filed: September 12, 2008
    Publication date: March 19, 2009
    Applicant: University of Rochester
    Inventors: Robert W. Boyd, Daniel J. Gauthier, Zhimin Shi
  • Publication number: 20020015103
    Abstract: A method of capturing and processing a digital image with a depth channel comprises receiving reflective and deflective light beams from an object, sensing the received light beams to generate digital images with distance information, storing the digital images, including the depth channel, and analyzing and processing the digital images with the depth channel. The original two-dimensional digital image may be processed or recreated as quasi three-dimensional digital images through the adjustment of such depth channel attached to the digital image. The system includes generally at least a lens and a CCD unit. The lens is attached to a housing of the system, such as a camera. The storage device and the CPU are mounted within the housing. Further a grid beam light unit may be provided as either an internal or external unit.
    Type: Application
    Filed: July 25, 2001
    Publication date: February 7, 2002
    Inventor: Zhimin Shi
  • Patent number: 5150215
    Abstract: A dual film and still video camera is provided for taking pictures in film and still video images either simultaneously or respectively. The camera comprises a casing, an objective lens, a film loading back, a view finder unit, at least one reflex mirror turntable upward and downward, a still video image capturing unit provided at the focusing screen of the view finder or at a mirror plane of the focusing screen in the lower portion of the casing, means for controlling camera operated in three modes of a video mode, a film mode and a dual mode; and a programmed releasing button for starting the image capturing unit and releasing an film exposure shutter in accordance with one of the three mode selected. The view finder unit can be an electronic view finder system. The reflex mirror can turn from a normally inclined facing up position to a declined facing down position and then turn further up to a horizontal facing down position and return the normal position afterwards.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: September 22, 1992
    Inventor: Zhimin Shi
  • Patent number: 5143252
    Abstract: A portable package for storing and dispensing photographic film cartridges is constructed by a package of film cartridges and a housing of the package. The package contains two or more cartridges in it. Both the package and the housing have matching outlets for dispensing the cartridges.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: September 1, 1992
    Inventor: Zhimin Shi