Abstract: A driving tool, including a driver assembly and a lifting assembly. The driver assembly includes a drivable driver member and a base arranged on the driver member, where the driver member extends longitudinally in a first axis, and a plurality of engagement holes arranged in the first axis are provided on the driver member. The lifting assembly includes a driving wheel that is driven by a power output portion to rotate and a plurality of fitting portions arranged on a periphery of the driving wheel at intervals, where the plurality of fitting portions can be alternately engaged with the corresponding engagement holes, to drive the driver member to move along the first axis, so as to drive the base to move from a starting position to a driven position.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: The seismic imaging resolution analysis method comprises: obtaining common-shot gathers and common-detector gathers; in the common-shot gathers, conducting detector focusing analysis on a focus point at (xj, zn) in each source point gather to obtain a source point focal-beam gather; looping all the focus points at a depth zn, and conducting computation on a weighted source-focusing operator Pik† (zn, zn); in the common-detector gathers, conducting source point focusing analysis on an focus point at (xj, zn) in each source point gather to obtain a detector focal-beam gather; Loop all the focus points at a depth zn, and conducting computation on a weighted detector-focusing operator Pik (zn, zn); and conducting computation on a normalized resolution function of a single focus point so as to obtain a horizontal resolution and a definition.

Abstract: The present application discloses a cable arranging mechanism, a connecting plate for distribution and a distribution frame. The cable arranging mechanism provided by the present application includes a first plate body and a second plate body which are capable of being clamped with each other. The first plate body is provided with an opening for a connector of a cable to pass through. When the second plate body and the first plate body are separated from each other, the cable and the connector thereof are capable of passing through the opening. When the second plate body and the first plate body are clamped with each other, at least one through hole for the cable to pass through is formed. The overall space occupied by the cable arranging mechanism provided by the present application is very small.

Abstract: A device for decomplexation and enhanced removal of copper based on self-induced Fenton-like reaction constructed by electrochemistry coupled with membrane separation is disclosed. The device includes a reactor, two electrocatalytic anodes capable of generating hydroxyl radicals, an electrocatalytic cathode membrane assembly, a direct current power supply, an aeration system, an inlet pipe and an outlet pipe. The device of the present invention has a simple construction. Using this device to treat industrial wastewater containing copper complexes under specific conditions allows the decomplexation and the removal of the industrial wastewater containing the copper complexes to be simultaneously realized at a low consumption and a high efficiency. The coupling of electrochemistry with membrane separation can be achieved to protect the cathode from being contaminated by pollutants in the sewage and prolong the service life of the electrode.

Abstract: Techniques for low power voice communications include determining a time between an arrival of data for uplink transmission by a device and a scheduling request (SR) occasion, the SR occasion occurring after the arrival of the data and within an on duration of a discontinuous reception (DRX) cycle, and delaying transmission of a SR by the device during a time period that begins at the arrival of the data for uplink transmission and continues for the determined time.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: The disclosure provides a method for preparing an amphiphilic lignin nanomaterial based on pulping black liquor, an amphiphilic lignin nanomaterial, and an oil sludge detergent. In the disclosure, physical treatments such as ball milling and high-pressure jet homogenization treatment are conducted on alkali lignin at the early stage to adjust the molecular weight and size of alkali lignin and thus to give alkali lignin nanoparticles with uniform particle sizes; and on this basis, a chemical treatment such as alkylation grafting modification is conducted to give amphiphilic lignin nanoparticles with both hydrophilicity and lipophilicity. Due to the nano-size effect, the amphiphilic lignin nanomaterial has a significantly-increased specific surface area (SSA) and effectively-improved surface properties, which can reduce the oil-water interfacial tension, and emulsify the crude oil and peel off the crude oil from the surface of rock particles, so as to achieve the purpose of oil-solid separation.

Abstract: A user equipment (UE) includes first and second subscriber identity modules (SIMs), possibly subscribed to different carriers. When the first SIM is in a connected state and the second SIM is in an idle state, the UE may need to periodically tune away a radio from a first frequency used for communication under the first SIM to a second frequency used for idle mode activity under the second SIM. The UE may provide to the network of the first SIM the second SIMs traffic activity pattern and/or serving frequency so that the network may provide coordinated configuration and/or scheduling for the UE device, e.g., in order to make the action of tuning away (and tuning back) the radio more efficient and/or to decrease the network impact of such radio tune aways (e.g., to decrease wasted uplink scheduling and wasted downlink transmissions for the first SIM).

Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: The present invention relates to pharmaceutical compositions comprising (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide for the treatment of B-cell malignancies.

Abstract: Provided is a high permeance nanofiltration membrane with nanoring-like structure and preparation method thereof. The membrane includes a base film and a polyamide layer having nanoring-like structure morphology on its surface. The method includes: (1) formulating a piperazine nanoemulsion containing a surfactant, vegetable oil, piperazine and water; and (2) infiltrating a base film with the piperazine nanoemulsion, and removing excess droplets from the surface of the base film to obtain a treated base film; covering the surface of the treated base film with a solution of trimesoyl chloride in n-hexane to perform interfacial polymerization; and drying the resulting membrane.

Abstract: A method, a system, and a device for full-waveform inversion deghosting for a marine variable depth streamer data acquisition are provided for solving existing problems that deghosted seismic data has low accuracy and is accompanied by artifacts due to a large error in ghost prediction. The provided method includes: acquiring seismic data, jointly solving Lippmann-Schwinger equations to obtain normal derivatives of an incident wave field and a wave field of a receiver surface, performing a wave field extrapolation by a Kirchhoff equation that includes only an integral on the receiver surface to obtain a wave field of a sea surface recorded by a horizontal streamer, calculating a ghost operator, and subjecting the ghosted wave field of the sea surface recorded by the horizontal streamer to full-waveform inversion deghosting to obtain deghosted seismic data. The provided method improves the accuracy and signal-to-noise ratio (SNR) of deghosted seismic data.

Abstract: The present invention relates to a target-oriented seismic acquisition method and apparatus, a medium and a device. The target-oriented seismic acquisition method comprises the steps of: giving parameters of an initial velocity model and a three-dimensional seismic layout aiming to an underground target position; conducting wave field continuation and focusing analysis on the three-dimensional seismic layout, and calculating distribution of seismic energy on the ground in an underground target region; conducting normalization processing on distribution of the seismic energy on the ground, and then conducting level partitioning to obtain a primary energy region and a secondary energy region; adding the number of shot points in the primary energy region to achieve target-oriented acquisition, and obtaining a target-oriented inhomogeneous laying acquired data imaging result.

Abstract: This disclosure relates to systems, apparatuses, and methods for coordinating communication and avoiding and/or mitigating collisions for multi-subscriber identity module devices in a wireless communication system. A wireless device may coordinate communication associated with different subscriber identity modules and/or may mitigate collisions between communications associated with different subscriber identity modules. A network may provide information to improve coordination and/or mitigate collisions. A network may adjust paging schedules and/or provision of alert messages to improve coordination.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. Also, disclosed a pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a targeted therapy agent and the use thereof.

Abstract: Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b ][1,4] oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives used as antagonists of IAPs (Inhibitors Apoptosis Proteins), also known as Smac mimetics. Disclosed herein is the use of these antagonists for inducing or sensitizing cells to the induction of apoptotic cell death, and the use of such compounds for treating proliferative disease such as cancer.

Abstract: Disclosed herein are heterocyclic compounds that may be used as STING modulators, the process for synthesis and to the use of such compounds in treatment of various diseases including cancers.

Abstract: The present disclosure belongs to the technical field of seismic exploration imaging, and relates to an interpretive-guided velocity modeling seismic imaging method and system, a medium and a device. The method comprises the following steps: S1. performing first imaging on a given initial velocity model to obtain a first imaging result; S2. performing relative wave impedance inversion on the first imaging result to obtain a relative wave impedance profile; S3. performing Curvelet filtering on the relative wave impedance profile to obtain a first interpretation scheme; S4. superposing the first interpretation scheme and the initial velocity model to obtain a new migration velocity field; S5. performing second imaging on a new migration velocity field to obtain a second imaging result; and S6. repeating steps S2-S4 for the obtained second imaging result until a final seismic imaging result is obtained.