Patents by Inventor Zhiwen Zhou

Zhiwen Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Storage stable recombinant lentiviral vector preparation
    Patent number: 9969984
    Abstract: Herein is provided a recombinant lentiviral vector preparation, in which the preparation comprises: a) an effective dose of the recombinant lentiviral vector; b) a histidine hydrochloride buffer for keeping a pH value of the preparation in the range of 6.0-8.0; and c) a carbohydrate.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: May 15, 2018
    Assignee: BEIJING SOLOBIO GENETECHNOLOGY COMPANY LTD.
    Inventors: Jundie Fan, Lixin Jiang, Zhiwen Zhou
  • RECOMBINANT LENTIVIRAL VECTOR PREPARATION
    Publication number: 20150056696
    Abstract: Herein is provided a recombinant lentiviral vector preparation, in which the preparation comprises: a) an effective dose of the recombinant lentiviral vector; b) a histidine hydrochloride buffer for keeping a pH value of the preparation in the range of 6.0-8.0; and c) a carbohydrate.
    Type: Application
    Filed: March 22, 2013
    Publication date: February 26, 2015
    Inventors: Jundie Fan, Lixin Jiang, Zhiwen Zhou
  • Group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof
    Patent number: 8779113
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: July 15, 2014
    Assignee: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen Zhou, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins
    Patent number: 8487157
    Abstract: Transgenic rodents having NGF beta gene mutants in their genomes express NGF beta mutant proteins. The preparation methods of the transgenic rodents, the methods of utilizing the transgenic animals to prepare NGF beta mutant proteins and the resulting NGF beta mutant proteins are provided. The transgenic rodents are useful in preparing human NGF and in the study of the functions of NGF beta mutants and their receptors in the whole animal level, and also useful for screening and purifying NGF beta mutants which have high activity and high security.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: July 16, 2013
    Assignee: Staidson (Beijing) Pharmaceutical Co., Ltd.
    Inventors: Zhiwen Zhou, Hongshan Zhang, Hongbo Chen
  • Group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof
    Patent number: 8383804
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: February 26, 2013
    Assignee: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen Zhou, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof
    Patent number: 8283462
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: October 9, 2012
    Assignee: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen Zhou, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof
    Patent number: 8263761
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: September 11, 2012
    Assignee: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen Zhou, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Group of Nucleic Acid Fragments for Prevention of HIV Infection or AIDS and the Usage Thereof
    Publication number: 20110217361
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Application
    Filed: January 10, 2011
    Publication date: September 8, 2011
    Applicant: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen ZHOU, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Group of Nucleic Acid Fragments for Prevention of HIV Infection or AIDS and the Usage Thereof
    Publication number: 20110217362
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Application
    Filed: January 10, 2011
    Publication date: September 8, 2011
    Applicant: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen ZHOU, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Group of Nucleic Acid Fragments for Prevention of HIV Infection or AIDS and the Usage Thereof
    Publication number: 20110189264
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Application
    Filed: January 10, 2011
    Publication date: August 4, 2011
    Applicant: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen ZHOU, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Group of Nucleic Acid Fragments for Prevention of HIV Infection or AIDS and the Usage Thereof
    Publication number: 20110117188
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 19, 2011
    Applicant: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen ZHOU, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • TRANSGENIC RODENTS HAVING NGF BETA GENE MUTANTS AND ITS PREPARATION METHODS, THE PREPARATION METHODS OF THE CORRESPONDING MUTANT PROTEINS AND THE RESULTING MUTANT PROTEINS
    Publication number: 20110082285
    Abstract: Transgenic rodents having NGF beta gene mutants in their genomes express NGF beta mutant proteins. The preparation methods of the transgenic rodents, the methods of utilizing the transgenic animals to prepare NGF beta mutant proteins and the resulting NGF beta mutant proteins are provided. The transgenic rodents are useful in preparing human NGF and in the study of the functions of NGF beta mutants and their receptors in the whole animal level, and also useful for screening and purifying NGF beta mutants which have high activity and high security.
    Type: Application
    Filed: March 7, 2008
    Publication date: April 7, 2011
    Applicant: STAIDSON (BEIJING) PHARMACEUTICAL CO., LTD
    Inventors: Zhiwen Zhou, Hongshan Zhang, Hongbo Chen
  • Group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof
    Patent number: 7906641
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: March 15, 2011
    Assignee: Beijing Solobio Genetechnology Company Ltd.
    Inventors: Zhiwen Zhou, Yuxia Feng, Conglin Zuo, Yuejuan Li
  • Medicines containing nerve growth factor for assisting losing weight and methods for assisting losing weight using same
    Publication number: 20070167362
    Abstract: A medicine for assisting losing weight contains nerve growth factor. Further, a method for assisting losing weight includes administering an effective amount of this medicine for assisting losing weight to a subject in need thereof.
    Type: Application
    Filed: January 18, 2006
    Publication date: July 19, 2007
    Inventors: ZhiWen Zhou, YuXia Feng, Conglin Zuo
  • Group of nucleic acid fragments for prevention of hiv infection or aids and the usage thereof
    Publication number: 20060217326
    Abstract: The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments, which are highly homogenous to all the published HIV gene sequences, were obtained by homology compare. The double-stranded RNA (dsRNA) derived from these fragments can effectively inhibit the expression of the HIV genes. The RNA transcribed by plasmid, also can suppress the expression of the HIV in the cell. After the adenovirus or associated virus which carry DNA corresponding above RNA infect the cell, the transcription dsRNA can inhibit the expression of the HIV genes.
    Type: Application
    Filed: December 16, 2003
    Publication date: September 28, 2006
    Inventors: Zhiwen Zhou, Yuxia Feng, Conglin Zuo, Yuejuan Li