Abstract: The present application relates to a sofa unfolding device capable of avoiding forward overturning, including a seat, a backrest assembly, a linkage assembly, and a leg rest assembly, wherein the linkage assembly is rotatably connected on the seat, the backrest assembly is rotatably connected to a rear end of the seat via the linkage assembly, the leg rest assembly is rotatably connected to a front end of the seat via the linkage assembly, a support mechanism is connected on the front end of the seat and comprises an abutting member and a support member, the abutting member is rotatably connected with the linkage assembly via a first pivot, and the support member is rotatably connected with the abutting assembly via a second pivot and is rotatably connected with the seat via a third pivot.

Abstract: The present application relates to an image processing method and system. The method includes: determining an enhanced image of a target object of an input image based on a segmentation algorithm, where the enhanced image of the target object comprises an image in which each pixel classified as the target object is displayed in an enhanced manner; and determining a positioning image of the target object by applying an integral image algorithm to the enhanced image of the target object.

Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: A method for detecting a number of tabs includes determining a pixel value of a first target pixel based on at least one pixel value of at least one first adjacent pixel adjacent to a first target pixel on a tab framework, and determining the number of tabs based on the pixel value of the first target pixel. Each of the at least one first adjacent pixel is an adjacent pixel of the first target pixel on a side in a first direction on the tab framework.

Abstract: A method and an apparatus for inspecting tab appearance of cell assembly, an electronic device, a non-transitory computer-readable storage medium, and a computer program product are provided. The method includes: obtaining an image for inspection that includes a background region and a cell assembly image region, where the cell assembly image region includes a body zone and a plurality of tab stacking regions, each tab stacking region adjoining a top edge or a bottom edge of the body zone; determining each root corner of the plurality of tab stacking regions in the image for inspection; determining two side edges of the body zone in the image for inspection; determining at least one reference edge line in the image for inspection based on the two side edges of the body zone in the image for inspection; and determining result information of the tab appearance inspection based on each root corner of the plurality of tab stacking regions in the image for inspection and the at least one reference edge line.

Abstract: A high-precision positioning method and system for a high-speed train is provided, which belongs to the technical field of high-speed train positioning. A multi-objective optimization model is first established. An objective function is a function obtained by weighing a positioning error function of the BeiDou satellite navigation system, a distance error function and a direction error function of the inertial navigation system. Constraint conditions include a positioning error constraint of the BeiDou satellite navigation system, a distance error constraint and a direction error constraint of the inertial navigation system, and a positioning error constraint of an electronic map. The multi-objective optimization model is solved with first positioning data of the BeiDou satellite navigation system and second positioning data of the inertial navigation system as inputs thereof by using an improved differential evolution algorithm, to obtain optimal positioning data of the high-speed train.

Abstract: A benzo[b]selenophene STING regulator, a preparation method therefore and use thereof are disclosed. The structure of the compound is shown in Formula I. A derivative, salt, stereoisomer, prodrug molecule and pharmaceutical composition of the present invention can serve as an immune regulator to effectively activate an innate immune regulation passageway to kill tumor cells.

Abstract: The present invention relates to the discovery of small molecule compounds that act as GLP-1R agonists and/or as positive allosteric modulators (PAMs) of GLP-1R. Such compounds are useful to treat, ameliorate, and/or prevent insulin resistance and/or diabetes in a mammal.

Abstract: A bicycle repair system comprises an intelligent bicycle locking device, an intelligent toolbox, and a central processing unit. The intelligent bicycle locking device is connected to the central processing unit, and the intelligent toolbox is connected to the central processing unit. The intelligent bicycle locking device is configured to send an obtained first user information to the central processing unit. The intelligent toolbox is configured to send an obtained second user information to the central processing unit. The central processing unit is configured to determine whether the second user information is the same as the first user information and, if yes, send an opening instruction to the intelligent toolbox sending the second user information, so as to help a user to repair a damaged bicycle by using the intelligent toolbox, so that the bicycle can be repaired without depending on a repair person, thereby improving the repair efficiency.

Abstract: A steel girder pavement structure (100) for high-speed road for bicycle, and a roadbed pavement method therefor. The pavement structure (100) includes a top plate (10), a bottom plate (20), a web (30), stiffening plates (40), and decorative plates (50). A composite roadbed is paved on a surface layer of the top plate (10). The composite roadbed includes, from bottom to top, a substrate, a primer coating and quartz sand (101), a waterproof coating (102), an anti-slip coating and quartz sand (103), a wear-resistant coating (104) and an anti-ultraviolet coating (105). The roadbed pavement method includes: paving various layers of materials on a surface of the steel plate from bottom to top. The high-speed road for bicycle is easy to seamlessly connect to a transportation hub, and has a high comfort degree.

Abstract: Disclosed are a steel girder pavement structure (100) for high-speed road for bicycle, and a roadbed pavement method therefor. The pavement structure (100) includes a top plate (10), a bottom plate (20), a web (30), stiffening plates (40), and decorative plates (50). A composite roadbed is paved on a surface layer of the top plate (10). The composite roadbed includes, from bottom to top, a substrate, a primer coating and quartz sand (101), a waterproof coating (102), an anti-slip coating and quartz sand (103), a wear-resistant coating (104) and an anti-ultraviolet coating (105). The roadbed pavement method includes: paving various layers of materials on a surface of the steel plate from bottom to top. The high-speed road for bicycle is easy to seamlessly connect to a transportation hub, and has a high comfort degree.

Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

Abstract: A bicycle repair system comprises an intelligent bicycle locking device, an intelligent toolbox, and a central processing unit. The intelligent bicycle locking device is connected to the central processing unit, and the intelligent toolbox is connected to the central processing unit. The intelligent bicycle locking device is configured to send an obtained first user information to the central processing unit. The intelligent toolbox is configured to send an obtained second user information to the central processing unit. The central processing unit is configured to determine whether the second user information is the same as the first user information and, if yes, send an opening instruction to the intelligent toolbox sending the second user information, so as to help a user to repair a damaged bicycle by using the intelligent toolbox, so that the bicycle can be repaired without depending on a repair person, thereby improving the repair efficiency.

Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

Abstract: The present invention relates to a method for controlling an electronic spreadsheet on a handheld touch device, comprising an operation procedure, a display procedure and a recovery procedure. The operation procedure comprises: receiving a selection touch control signal for selecting cells, determining selected cells in an electronic spreadsheet according to the selection touch control signal, calculating according to a preset processing method, and storing the calculation result. The display procedure comprises: receiving a first touch control signal for controlling movement of an electronic spreadsheet from an initial position of the electronic spreadsheet to an interim position, moving the electronic spreadsheet from the initial position of the electronic spreadsheet to the interim position according to the first touch control signal to expose a blank area, querying whether the calculation result exists or not, and if yes, displaying the calculation result in the blank area.

Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

Abstract: The present invention relates to a method for controlling an electronic spreadsheet on a handheld touch device, comprising an operation procedure, a display procedure and a recovery procedure. The operation procedure comprises: receiving a selection touch control signal for selecting cells, determining selected cells in an electronic spreadsheet according to the selection touch control signal, calculating according to a preset processing method, and storing the calculation result. The display procedure comprises: receiving a first touch control signal for controlling movement of an electronic spreadsheet from an initial position of the electronic spreadsheet to an interim position, moving the electronic spreadsheet from the initial position of the electronic spreadsheet to the interim position according to the first touch control signal to expose a blank area, querying whether the calculation result exists or not, and if yes, displaying the calculation result in the blank area.

Abstract: Functionalized magnetic particles are emerging as a reliable and convenient technique in the purification of biomacromolecules (proteins and nucleic acids). We disclose a novel coupling procedure that can be used to create stable ferromagnetic nickel particles coated with Protein A for the affinity purification of antibody. The protein purification procedure is gentle, scalable, automatable, efficient and economical. By modifying the functional groups of amino acids in the protein coating, nickel particles can be used not only for affinity purification but for other sample preparation and chromatographic applications as well including nucleic acid isolations. The method can be easily modified for small and medium scale antibody purification in lab and pre-clinical research.