Abstract: The invention relates to the technical field of medicine, and provides a method of screening and identifying small molecule with anti-aging properties. The method comprises cellular models, namely premature aging mouse embryonic fibroblasts and human HGPS mesenchymal stem cells and animal models, namely premature aging progeroid mice and Caenorhabditis elegans. The method successfully screened and identified Cannabidiol (CBD), which had senolytic effects. The invention also determined that the optimal concentration of CBD treatment is 10-20 ?M.

Abstract: The invention relates to the technical field of medicine, and provides a method of screening and identifying small molecule with antiviral properties. The invention has screened and identified Cannabidiol (CBD), which can be used for prevention of viral infections. The invention also examined and verified that CBD can be used for prevention of COVID-19 disease, by a key signaling pathway of upregulating the expression of the TRIB3 gene. The invention also determined that the optimal dosage of CBD treatment for prevention of COVID-19 disease is 5 ?M-10 ?M.

Abstract: In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.

Abstract: In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.

Abstract: In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.

Abstract: The present invention relates to Trash field. More particularly, the present invention relates to Trash can lid. The present invention provides a design of a big lid and a small lid. When an inhabitant usually disposes trash, he or she need only press a button to open the small lid. Since the small lid is connected with the big lid by magnetism and a spring buffer unit is installed in the seat of small lid, opening the small lid is very smooth, without any noise or vibration. When a dustman collects the trash, what he needs to do is only to open the big lid, being very convenient and sanitary.

Abstract: A dustbin relates to a composite dustbin that can be easily assembled by and disassembled into parts. It is also characterized by pretty appearance, small coverage of warehouse area, low transport fee and good market prospects.

Abstract: A dustbin relates to a composite dustbin that can be easily assembled by and disassembled into parts. It is also characterized by pretty appearance, small coverage of warehouse area, low transport fee and good market prospects.

Abstract: The present invention relates to Trash field. More particularly, the present invention relates to Trash can lid. The present invention provides a design of a big lid and a small lid. When an inhabitant usually disposes trash, he or she need only press a button to open the small lid. Since the small lid is connected with the big lid by magnetism and a spring buffer unit is installed in the seat of small lid, opening the small lid is very smooth, without any noise or vibration. When a dustman collects the trash, what he needs to do is only to open the big lid, being very convenient and sanitary.