Abstract: The present disclosure provides a system for MRI. The system may obtain a plurality of auxiliary signals and a plurality of imaging signals collected by applying an MRI pulse sequence simultaneously to a plurality of slice locations of a subject. For each of at least one target slice location of the plurality of slice locations, the system may generate at least one target image of the target slice location based on the plurality of auxiliary signals and the plurality of imaging signals. During the application of the MRI pulse sequence, phase modulation may be applied to at least one of the plurality of slice locations so that the plurality of slice locations have different phases during the readout of at least one of the plurality of imaging signals.

Abstract: An imaging method may include obtaining imaging data associated with a region of interest (ROI) of an object. The imaging data may correspond to a plurality of time-series images of the ROI. The imaging method may also include determining, based on the imaging data, a data set including a spatial basis and one or more temporal bases. The spatial basis may include spatial information of the imaging data. The one or more temporal bases may include temporal information of the imaging data. The imaging method may also include storing, in a storage medium, the spatial basis and the one or more temporal bases.

Abstract: A method for magnetic resonance imaging (MRI) may include obtaining imaging signals related to a region of interest (ROI) of a subject. The method may also include selecting a portion of the imaging signals as auxiliary signals associated with at least one temporal dimension of the ROI. The method may also include generating at least one target image associated with the at least one temporal dimension of the ROI based on the imaging signals and the auxiliary signals.

Abstract: This disclosure provides a system and a method. The method may include: determining a processing instruction; acquiring image data based on the processing instruction; determining a configuration file based on the image data, in which the configuration file may be configured to guide implementation of the processing instruction; constructing a data processing pipeline based on the configuration file; executing the data processing process based on the data processing pipeline, in which the data processing process may be generated based on the data processing pipeline; generating a processing result of the image data based on the executed data processing process; and storing the processing result of the image data in a first storage space.

Abstract: Systems and methods are described for reducing lab-to-lab and/or instrument-to-instrument variability of Multi-Attribute Methods (MAM) analyses via run-time signal intensity calibration. In various aspects, multiple MAM-based instruments each have detectors and different instrument conditions defined by different instrument models or sets of settings. Each MAM-based instrument receives respective samples and a reference standard as a calibrant. Each MAM-based instrument detects, via its detector, sample isoforms of its respective sample and reference standard isoforms of the reference standard. The MAM-based instruments are associated with processor(s) that determine, via respective MAM iterations, correction factors and sample abundance values corresponding to the sample isoforms. The correction factors are based on the reference standard, and the sample abundance values are based on the correction factors.

Abstract: The present disclosure provides systems and methods for MR T1 mapping. A method may include obtaining at least three images of a subject acquired within an inversion recovery (IR) process, each image of the at least three images being acquired within a cardiac cycle during a breath-hold of the subject; and determining a T1 map of the subject based on the at least three images acquired within the IR process and a trained model.

Abstract: A method for magnetic resonance imaging (MRI) may include obtaining imaging signals related to a region of interest (ROI) of a subject. The method may also include selecting a portion of the imaging signals as auxiliary signals associated with at least one temporal dimension of the ROI. The method may also include generating at least one target image associated with the at least one temporal dimension of the ROI based on the imaging signals and the auxiliary signals.

Abstract: The present disclosure provides materials and methods for determining the presence of an N-terminal modification on a therapeutic protein, and/or the efficiency of N-terminal modification, such as PEGylation, at the N-terminus of a therapeutic protein such as Filgrastim (wherein the PEGylated version is therefore Pegfilgrastim).

Abstract: The present disclosure provides systems and methods for MR T1 mapping. A method may include obtaining at least three images of a subject acquired within an inversion recovery (IR) process, each image of the at least three images being acquired within a cardiac cycle during a breath-hold of the subject; and determining a T1 map of the subject based on the at least three images acquired within the IR process and a trained model.

Abstract: A system and method for correcting phase shift in echo images are provided. The method may include one or more of the following operations. A plurality of echo images may be obtained. Homogeneous pixels in the plurality of echo images may be identified. A vector corresponding to each of at least some of the identified homogeneous pixels may be determined. A vector of a homogenous pixel includes a phase element and an amplitude element. A first complex linear model of phase shift may be determined based at least in part on the determined vectors. Phase shift of at least one of the plurality of echo images may be corrected based on the first complex linear model.

Abstract: A method may include obtaining a plurality of imaging signals collected by applying a wave encoding gradient to a region of interest (ROI) of a subject. The method may also include obtaining a plurality of auxiliary signals associated with the ROI. The method may also include obtaining a point spread function corresponding to the wave encoding gradient. The method may also include determining, based on the plurality of auxiliary signals, temporal information relating to at least one temporal dimension of the ROI. The method may also include determining, based on the plurality of auxiliary signals, the plurality of imaging signals, and the point spread function, spatial information relating to at least one spatial dimension of the ROI. The method may also include generating at least one target image of the ROI based on the temporal information and the spatial information.

Abstract: A touch panel and a manufacturing method thereof, and a display device are provided. The touch panel includes a base substrate, the base substrate includes a touch area and a lead end area; the touch area is provided with a plurality of first electrodes and a plurality of second electrodes, and the second electrodes are intersected with and insulated from the first electrodes; a plurality of leads, electrically connected with the plurality of first electrodes and the plurality of second electrodes respectively, and connected to the lead end area (120), and the plurality of leads include a transparent conductive layer lead.

Abstract: The present disclosure provides a system for MRI. The system may obtain a plurality of auxiliary signals and a plurality of imaging signals collected by applying an MRI pulse sequence simultaneously to a plurality of slice locations of a subject. For each of at least one target slice location of the plurality of slice locations, the system may generate at least one target image of the target slice location based on the plurality of auxiliary signals and the plurality of imaging signals. During the application of the MRI pulse sequence, phase modulation may be applied to at least one of the plurality of slice locations so that the plurality of slice locations have different phases during the readout of at least one of the plurality of imaging signals.

Abstract: This disclosure provides a system and a method. The method may include: determining a processing instruction; acquiring image data based on the processing instruction; determining a configuration file based on the image data, in which the configuration file may be configured to guide implementation of the processing instruction; constructing a data processing pipeline based on the configuration file; executing the data processing process based on the data processing pipeline, in which the data processing process may be generated based on the data processing pipeline; generating a processing result of the image data based on the executed data processing process; and storing the processing result of the image data in a first storage space.

Abstract: This disclosure provides a system and a method. The method may include: determining a processing instruction; acquiring image data based on the processing instruction; determining a configuration file based on the image data, in which the configuration file may be configured to guide implementation of the processing instruction; constructing a data processing pipeline based on the configuration file; executing the data processing process based on the data processing pipeline, in which the data processing process may be generated based on the data processing pipeline; generating a processing result of the image data based on the executed data processing process; and storing the processing result of the image data in a first storage space.

Abstract: The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.

Abstract: A driving control device includes a touch unit configured to acquire fingerprint information of a user and generate touch signals according to the fingerprint information, in which the touch signals include the fingerprint information; and a controller configured to generate driving control signals according to the fingerprint information in the touch signals and output the driving control signals to a vehicle to control traveling parameters of the vehicle. A vehicle and a driving control method are further provided.

Abstract: Systems and methods are described for reducing lab-to-lab and/or instrument-to-instrument variability of Multi-Attribute Methods (MAM) analyses via run-time signal intensity calibration. In various aspects, multiple MAM-based instruments each have detectors and different instrument conditions defined by different instrument models or sets of settings. Each MAM-based instrument receives respective samples and a reference standard as a calibrant. Each MAM-based instrument detects, via its detector, sample isoforms of its respective sample and reference standard isoforms of the reference standard. The MAM-based instruments are associated with processor(s) that determine, via respective MAM iterations, correction factors and sample abundance values corresponding to the sample isoforms. The correction factors are based on the reference standard, and the sample abundance values are based on the correction factors.

Abstract: An imaging method may include obtaining imaging data associated with a region of interest (ROI) of an object. The imaging data may correspond to a plurality of time-series images of the ROI. The imaging method may also include determining, based on the imaging data, a data set including a spatial basis and one or more temporal bases. The spatial basis may include spatial information of the imaging data. The one or more temporal bases may include temporal information of the imaging data. The imaging method may also include storing, in a storage medium, the spatial basis and the one or more temporal bases.

Abstract: A system and method for correcting phase shift in echo images are provided. The method may include one or more of the following operations. A plurality of echo images may be obtained. Homogeneous pixels in the plurality of echo images may be identified. A vector corresponding to each of at least some of the identified homogeneous pixels may be determined. A vector of a homogenous pixel includes a phase element and an amplitude element. A first complex linear model of phase shift may be determined based at least in part on the determined vectors. Phase shift of at least one of the plurality of echo images may be corrected based on the first complex linear model.