Abstract: The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.

Abstract: Apparatus and method for a physical simulation experiment of fracturing an unconventional oil and gas reservoir layer by layer by spiral perforation via a horizontal well bore. The apparatus includes an outer wellbore provided with at least three layers of spiral perforations, and an inner wellbore provided with at least three layers of through-holes. The method includes injecting fracturing fluid into the inner wellbore, and opening a first layer cracks of a stratum by the fracturing fluid passing the first through-hole layer and the first spiral perforation layer, opening a second layer cracks of the stratum by the fracturing fluid passing second through-hole layer and second spiral perforation layer and opening a third layer cracks of the stratum by the fracturing fluid passing third through-hole layer and third spiral perforation layer.

Abstract: A single-chip two-axis magnetoresistive angle sensor comprises a substrate located in an X-Y plane, a push-pull X-axis magnetoresistive angle sensor and a push-pull Y-axis magnetoresistive angle sensor located on the substrate. The push-pull X-axis magnetoresistive angle sensor comprises an X push arm and an X pull arm. The push-pull Y-axis magnetoresistive angle sensor comprises a Y push arm and a Y pull arm. Each of the X push, X pull, Y push arm, and Y pull arms comprises at least one magnetoresistive angle sensing array unit. The magnetic field sensing directions of the magnetoresistive angle sensing array units of the X push, X pull, Y push, and Y pull arms are along +X, ?X, +Y and ?Y directions respectively. Each magnetoresistive sensing unit comprises a TMR or GMR spin-valve having the same magnetic multi-layer film structure.

Abstract: The present application relates to the field of pharmaceutical chemistry. The application specifically relates to a crystal form A and crystal form B of a pyrrolopyrimidine (formula I) for preparing a JAK inhibitor. The application further relates to a method for preparing the crystal form A and crystal form B, a crystalline composition comprising the crystal form A or crystal form B, a pharmaceutical composition comprising the crystal form A, crystal form B, or crystalline composition, and a pharmaceutical application of the pharmaceutical composition, the crystal form A, and the crystal form B. The crystal form A and crystal form B of the application has the advantages of high purity, high crystallinity, and good stability.

Abstract: An energy storage device including a first electrode comprising lithium, a second electrode comprising a metal diboride, an electrolyte disposed between the first electrode and the second electrode and providing a conductive pathway for lithium ions to move to and from the first electrode and the second electrode, and a separator within the electrolyte and between the first electrode and the second electrode. A method of forming an energy storage device including forming a first electrode to include lithium, forming a second electrode to include a metal diboride, disposing an electrolyte between the first electrode and the second electrode, the electrolyte providing a conductive pathway for lithium ions to move to and from the first electrode and the second electrode, and disposing a separator within the electrolyte and between the first electrode and the second electrode.

Abstract: The invention features a vital sign monitor that includes: 1) a hardware control component featuring a microprocessor that operates an interactive, icon-driven GUI on an LCD; and, 2) a sensor component that connects to the control component through a shielded coaxial cable. The sensor features: 1) an optical component that generates a first signal; 2) a plurality electrical components (e.g. electrodes) that generate a second signal; and, 3) an acoustic component that generates a third signal. The microprocessor runs compiled computer code that operates: 1) the touch panel LCD; 2) a graphical user interface that includes multiple icons corresponding to different software operations; 3) a file-management system for storing and retrieving vital sign information; and 4) USB and short-range wireless systems for transferring data to and from the device to a PC.

Abstract: Provided are a preparation method for a chiral pyrrolopyrimidine compound and a related intermediate. In the method, a compound of formula A and a compound of formula 6 or a salt thereof are reacted to obtain a compound of formula 7 or a compound of formula 14, and a compound of formula I is prepared from the compound of formula 7 or the compound of formula 14. Also provided are the intermediate used, a preparation method for the intermediate and a use of the intermediate in the preparation of the compound of formula I. The preparation method has characteristics such as brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and a convenient post-treatment. The method avoids using an expensive asymmetric reaction catalyst, and is suitable for industrial production.

Abstract: A fluid conduit includes a first portion and a second portion disposed at least partially around the first portion. The first portion may include an extruded thermoplastic. The second portion may include a plurality of layers formed via fiber reinforced thermoplastic tape, tows, and/or fabric. The first portion and the second portion may be substantially rigid and may include concentric cylindrical cross-sections. The fiber reinforced thermoplastic tape, tows, and/or fabric may include nano-additives and/or micro-additives.

Abstract: Apparatus and method for a physical simulation experiment of fracturing an unconventional oil and gas reservoir layer by layer by spiral perforation via a horizontal well bore. The apparatus includes an outer wellbore provided with at least three layers of spiral perforations, and an inner wellbore provided with at least three layers of through-holes. The method includes injecting fracturing fluid into the inner wellbore, and opening a first layer cracks of a stratum by the fracturing fluid passing the first through-hole layer and the first spiral perforation layer, opening a second layer cracks of the stratum by the fracturing fluid passing second through-hole layer and second spiral perforation layer and opening a third layer cracks of the stratum by the fracturing fluid passing third through-hole layer and third spiral perforation layer.

Abstract: The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.

Abstract: The invention features a vital sign monitor that includes: 1) a hardware control component featuring a microprocessor that operates as interactive, icon-driven GUI on an LCD; and, 2) a sensor component that connects to the control component through a shielded coaxial cable. The sensor features: 1) an optical component that generates a first signal; 2) a plurality electrical components (e.g. electrodes) that generate a second signal; and, 3) an acoustic component that generates a third signal. The microprocessor runs compiled computer code that operates: 1) the touch panel LCD; 2) a graphical user interface that includes multiple icons corresponding to different software operations; 3) a file-management system for storing and retrieving vital sign information; and 4) USB and short-range wireless systems for transferring data to and from the device to a PC.

Abstract: A method and apparatus for determining a building/urban profile image location includes extracting a building/urban profile from an obtained image and comparing the image to a database of building/urban profiles. The database may be created by obtaining point cloud data sets scanned building/urban profiles, converting the obtained point cloud data sets to a corresponding 3D surface model, and creating the database of stored building/urban profiles viewed from multiple locations within each of the 3D surface models. By comparing the extracted building/urban profile image with the stored building/urban profiles contained within the database and finding a match the location from which the extracted building/urban profile image was taken can be determined.

Abstract: An information processing method, a server, and a computer storage medium are provided. The method includes: generating a first information identification code according to first information, the first information representing an information source; providing the first information identification code to a terminal; receiving a first request from the terminal and allowing a terminal user of the terminal to follow an information service, the first request carrying the first information; and recording the first information and tracking and obtaining conversion information of the information source according to the first information.

Abstract: A method and apparatus for determining a building/urban profile image location includes extracting a building/urban profile from an obtained image and comparing the image to a database of building/urban profiles. The database may be created by obtaining point cloud data sets scanned building/urban profiles, converting the obtained point cloud data sets to a corresponding 3D surface model, and creating the database of stored building/urban profiles viewed from multiple locations within each of the 3D surface models. By comparing the extracted building/urban profile image with the stored building/urban profiles contained within the database and finding a match the location from which the extracted building/urban profile image was taken can be determined.

Abstract: A hanging system for securing cladding panel on a building structure, the cladding panel having a mounting channel extending at least partly across a surface thereof. An embedded anchor block has a core and two engaging portions outwardly projecting from the core, the two engaging portions operable to lock the anchor block in the mounting channel of the cladding panel in an interlocking fit when the embedded anchor block is received within the mounting channel, and the embedded anchor block having an outer surface that is configured to be flush or near flush with the surface of the cladding panel when the embedded anchor block is received within the mounting channel. A hanging clip removably connects or fastens to the anchor block, the hanging clip having an engagement surface to engage the outer surface of the anchor block. The cladding panel is secured to a building structure by fastening the anchor block to the hanging clip which is securable to a support.

Abstract: A method of protecting an article from a downhole environment comprises growing carbon nanotubes on a surface of a substrate via a chemical vapor deposition process; the carbon nanotubes having a first end formed on the surface of the substrate and a second end extending away from the substrate; filling the spaces among the carbon nanotubes with a metallic material or a polymeric material forming a coated article; and exposing the coated article to a downhole environment.

Abstract: A hanging system for securing cladding panel on a building structure, the cladding panel having a mounting channel extending at least partly across a surface thereof. An embedded anchor block has a core and two engaging portions outwardly projecting from the core, the two engaging portions operable to lock the anchor block in the mounting channel of the cladding panel in an interlocking fit when the embedded anchor block is received within the mounting channel, and the embedded anchor block having an outer surface that is configured to be flush or near flush with the surface of the cladding panel when the embedded anchor block is received within the mounting channel. A hanging clip removably connects or fastens to the anchor block, the hanging clip having an engagement surface to engage the outer surface of the anchor block. The cladding panel is secured to a building structure by fastening the anchor block to the hanging clip which is securable to a support.

Abstract: Dye compounds of the formula (1) wherein A is a protective agent group that has a characteristic of modifying the singlet-triplet occupancy of the shown cyanine moiety, and M is a reactive crosslinking group or a group that can be converted to a reactive crosslinking group. Methods for synthesizing the dye compounds and applications for their use are also described.

Abstract: The invention provides a monitor for measuring blood pressure and other vital signs from a patient without using a cuff. The invention provides a hand-held device for measuring vital signs (e.g.

Abstract: A system that includes a resource monitor and a resource consumer. The resource monitor keeps a state of resources that are available for consumption. For instance, the resources may be processing nodes in a distributed environment. The state of the resources kept by the resource monitor includes an estimated health score along a health score range for each of the resources being monitored. The resource monitor reports the resulting estimated health scores. The resource consumer uses at least some of the reported estimated health scores in order to determine which of the resources to consume. A higher estimated health score for a resource may result in the resource being more readily consumed. A lower estimated health score for a resource may result in consumption of the resource being more likely avoided.