Patents by Inventor Zhulan Li

Zhulan Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9849145
    Abstract: Provided is a pharmaceutical composition useful for prevention and/or treatment of diseases caused by bacteria, wherein the pharmaceutical composition comprising a honeysuckle extract containing iridoid compounds and an antibiotic. Also provided is a pharmaceutical kit comprising the honeysuckle extract containing the iridoid compounds and the antibiotics which are separately placed. The honeysuckle extract is used in combination with the antibiotics, the responsiveness of multi-drug resistant bacteria to antibiotics is improved, a clinical application prospect is presented, especially the current status of the refractory bacterial infection diseases caused by the pathogenic bacteria resistant to the antibiotics can be improved. Also provided is a use of the pharmaceutical composition and pharmaceutical kit in the preparation of drugs for prevention and/or treatment a diseases caused by bacteria.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: December 26, 2017
    Assignee: Hankang Biochemical & Pharmaceutical Co., Ltd
    Inventors: Tiejun Zhang, Jiangong Shi, Hong Meng, Fengnian Han, Xuwei Ma, Zhulan Li
  • Publication number: 20140193530
    Abstract: Provided is a pharmaceutical composition useful for prevention and/or treatment of diseases caused by bacteria, wherein the pharmaceutical composition comprising a honeysuckle extract containing iridoid compounds and an antibiotic. Also provided is a pharmaceutical kit comprising the honeysuckle extract containing the iridoid compounds and the antibiotics which are separately placed. The honeysuckle extract is used in combination with the antibiotics, the responsiveness of multi-drug resistant bacteria to antibiotics is improved, a clinical application prospect is presented, especially the current status of the refractory bacterial infection diseases caused by the pathogenic bacteria resistant to the antibiotics can be improved. Also provided is a use of the pharmaceutical composition and pharmaceutical kit in the preparation of drugs for prevention and/or treatment a diseases caused by bacteria.
    Type: Application
    Filed: August 12, 2011
    Publication date: July 10, 2014
    Inventors: Tiejun Zhang, Jiangong Shi, Hong Meng, Fengnian Han, Xuwei Ma, Zhulan Li
  • Patent number: 7388061
    Abstract: The present invention provides a solid catalyst component for the polymerization of olefins, comprising magnesium, titanium, a halogen and an electron donor, wherein said electron donor comprises at least one selected from the group consisting of ester of polyol of the formula (I): R1CO—O—CR3R4—A—CR5R6—O—CO—R2??(I) wherein, R1 and R2 groups, which may be identical or different, can be substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R3-R6 groups, which may be identical or different, can be selected from the group consisting of hydrogen, halogen or substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R1-R6 groups optionally contain one or more hetero-atoms replacing carbon, hydrogen atom or the both, said hetero-atom is selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus and halogen atom, two or more of R3-R6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring A is a single bond or bivalent linking group wit
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: June 17, 2008
    Assignees: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroleum & Chemical Corporation
    Inventors: Mingzhi Gao, Haitao Liu, Zhulan Li, Jun Wang, Juxiu Yang, Tianyi Li, Xiaodong Wang, Changxiu Li, Chunming Ding
  • Publication number: 20050239636
    Abstract: The present invention provides a solid catalyst component for the polymerization of olefins, comprising magnesium, titanium, a halogen and an electron donor, wherein said electron donor comprises at least one selected from the group consisting of polyol ester compounds of the formula (I): R1CO—O—CR3R4-A-CR5R6—O—CO—R2 (I) wherein, R1 and R2 groups, which may be identical or different, can be substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R3-R6 groups, which may be identical or different, can be selected from the group consisting of hydrogen, halogen or substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R1-R6 groups optionally contain one or more hetero-atoms replacing carbon, hydrogen atom or the both, said hetero-atom is selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus and halogen atom, two or more of R3-R6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring; A is a single bond or bivalent linking grou
    Type: Application
    Filed: January 30, 2003
    Publication date: October 27, 2005
    Inventors: Mingzhi Gao, Haitao Liu, Zhulan Li, Jun Wang, Juxiu Yang, Tianyi Li, Xiaodong Wang, Changxiu Li, Chunming Ding
  • Patent number: 6703339
    Abstract: A catalyst component for the (co)polymerization of olefins is provided. The catalyst comprises titanium, magnesium halogen and a mixed electron-donor and a catalyst for the (co)polymerization of olefins comprising:(A) the catalyst component; (B) an organic aluminum compound; and (C) an organic silicon compound. A polymer with high and adjustable stereospecificity and broad molecular weight distribution can be prepared by using the catalyst.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: March 9, 2004
    Assignees: China Petro-Chemical Corporation, Beijing Research Institute of Chemical Industry, Sinopec
    Inventors: Zhulan Li, Juxiu Yang, Mingzhi Gao, Yun Zhao, Bingquan Mao, Aichun Yang, Chunmin Ding, Wenbo Song, Kunzheng Liu
  • Patent number: 6683017
    Abstract: A catalyst system for the (co)polymerization of propylene contains (A) a solid catalyst component comprising titanium, magnesium, halogen and a 1,3-diether; (B) an organic aluminum compound; and optionally (C) an organic silicon compound. In comparison with the prior art, stereospecificity of the polymer prepared by using the catalyst system of this invention evenl containing no external electron-donor is greater than 99%. Also, the activity of the catalyst system and hydrogen gas adjustability on the molecular weight of the polymer do not significantly decrease.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: January 27, 2004
    Assignees: China Petro - Chemical Corporation, Beijing Research Institute of Chemical Industry
    Inventors: Mingzhi Gao, Jian Zhou, Yun Zhao, Zhulan Li, Yantoo Yang, Juxiu Yang, Weihua Feng
  • Patent number: 6376417
    Abstract: A catalyst for the polymerization of propylene comprising components (A), (B) and (C) is provided. Component (A) is a solid product prepared by dissolving a halide of magnesium in a solvent system consisting of an organic epoxy compound, an organic phosphorus compound and an inert diluent to form a homogeneous solution; mixing the homogeneous solution with a halide of titanium to form a mixture; precipitating a solid from the mixture in the presence of an auxiliary precipitant; treating the solid with a polycarboxylic ester to load the ester on the solid; and treating the ester loaded solid with the halide of titanium and the inert diluent. Component (B) is an organic aluminium compound, and component (C) is an organic silicon compound. The particle size of the catalyst can be adjusted by increasing the amount of the inert diluent at a low ratio of the epoxy compound to the phosphorus compound.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: April 23, 2002
    Assignees: China Petro Chemical Corp., Beijing Research Institute of Chemical Industry
    Inventors: Aichun Yang, Zhulan Li, Yun Zhao, Wenbo Song, Juziu Yang, Bingquan Mao, Huiru Yang
  • Publication number: 20020010081
    Abstract: The present invention relates to a catalyst component for the (co)polymerization of olefins comprising titanium, magnesium, halogen and a mixed electron-donor and a catalyst for the (co)polymerization of olefins comprisin: (A) the catalyst component; (B) an organic aluminum compound; and (C) an organic silicon compound. The polymer with high and adjustable stereospecificity and broad molecular weight distribution can be prepared by using the catalyst.
    Type: Application
    Filed: December 6, 2000
    Publication date: January 24, 2002
    Inventors: Zhulan Li, Juxiu Yang, Mingzhi Gao, Yun Zhao, Bingquan Mao, Aichun Yang, Chunmin Ding, Wenbo Song, Kunzheng Liu
  • Publication number: 20010025006
    Abstract: The present invention relates to a catalyst system for the (co)polymerization of propylene consisting of the following components:(A) a solid catalyst component comprising titanium, magnesium, halogen and a 1,3-diether; (B) an organic aluminum compound; and optionally (C) an organic silicon compound. In comparison with the prior art, stereospecificity of the polymer prepared by using the catalyst system of this invention even containing no external electron-donor is greater than 99%. Also, the activity of the catalyst system and hydrogen gas adjustability on the molecular weight of the polymer do not significantly decrease.
    Type: Application
    Filed: December 6, 2000
    Publication date: September 27, 2001
    Inventors: Mingzhi Gao, Jian Zhou, Yun Zhao, Zhulan Li, Yantao Yang, Juxiu Yang, Weihua Feng
  • Patent number: 4861847
    Abstract: A catalyst system for use in olefinic polymerization and copolymerization is comprised of components (A), (B) and (C). The catalyst component (A) consisting essentially of titanium, magnesium, halogen, polycarboxylic acid esters and organic phosphorus compounds is a solid product, being prepared by mixing titanium tetrahalide and auxiilary precipitant with a homogeneous solution of magnesium halide in a solvent system consisting essentially of an organic epoxy compound and an organic phosphorus compound to form a solid product which is then treated with a polycarboxylic acid ester and titanium tetrahalide. Component (B) is an organic aluminum compound, and component (C) is an organic silicon compound. The catalyst system has very high activity, and the resultant polymers have very high stereospecificity and good granular appearance.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: August 29, 1989
    Assignees: Beijing Research Institute of Chemical Industry, China Petrochemical Corp.
    Inventors: Bingquan Mao, Aichun Yang, Ying Zheng, Juxiou Yang, Zhulan Li
  • Patent number: 4784983
    Abstract: A catalyst system for use in olefinic polymerization and copolymerization is comprised of components (A), (B) and (C). The catalyst component (A) consisting essentially of titanium, magnesium, halogen, polycarboxylic acid esters and organic phosphorus compounds is a solid product, being prepared by mixing titanium tetrahalide and auxiliary precipitant with a homogeneous solution of magnesium halide in a solvent system consisting essentially of an organic epoxy compound and an organic phosphorus compound to form a solid product which is then treated with a polycarboxylic acid ester and titanium tetrahalide. Component (B) is an organic aluminum compound, and component (C) is an organic silicon compound. The catalyst system has a very high activity, and the resultant polymers have very high stereospecificity and good granular appearance.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: November 15, 1988
    Assignee: Beijing Research Institute of Chemical Industry
    Inventors: Bingquan Mao, Aichun Yang, Ying Zheng, Juxiou Yang, Zhulan Li