Patents by Inventor Zhulin Tan
Zhulin Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230183178Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.Type: ApplicationFiled: February 9, 2023Publication date: June 15, 2023Inventors: Phouvieng BEYER, Jason A. BRAZZILLO, Magnus ERIKSSON, Jon Charles LORENZ, Laurence J. NUMMY, Sonia RODRIGUEZ, Jolaine SAVOIE, Kanwar Pal Singh SIDHU, Joshua D. SIEBER, Thomas Gabriel TAMPONE, Zhulin TAN, Jun WANG, Li ZHANG, Weitong DONG, Pengtao ZHANG
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Patent number: 11603354Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.Type: GrantFiled: July 14, 2021Date of Patent: March 14, 2023Inventors: Phouvieng Beyer, Jason A. Brazzillo, Weitong Dong, Magnus Eriksson, Jon Charles Lorenz, Laurence J. Nummy, Sonia Rodriguez, Jolaine Savoie, Kanwar Pal Singh Sidhu, Joshua D. Sieber, Thomas Gabriel Tampone, Zhulin Tan, Jun Wang, Li Zhang, Pengtao Zhang
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Publication number: 20210340101Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.Type: ApplicationFiled: July 14, 2021Publication date: November 4, 2021Inventors: Phouvieng BEYER, Jason A. BRAZZILLO, Weitong DONG, Magnus ERIKSSON, Jon Charles LORENZ, Laurence J. NUMMY, Sonia RODRIGUEZ, Jolaine SAVOIE, Kanwar Pal Singh SIDHU, Joshua D. SIEBER, Thomas Gabriel TAMPONE, Zhulin TAN, Jun WANG, Li ZHANG, Pengtao ZHANG
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Publication number: 20200369611Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.Type: ApplicationFiled: July 30, 2018Publication date: November 26, 2020Inventors: Phouvieng BEYER, Jason A. BRAZZILLO, Magnus ERIKSSON, Jon Charles LORENZ, Laurence J. NUMMY, Sonia RODRIGUEZ, Jolaine SAVOIE, Kanwar Pal Singh SIDHU, Joshua D. SIEBER, Thomas Gabriel TAMPONE, Zhulin TAN, June WANG, Li ZHANG
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Patent number: 10544177Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.Type: GrantFiled: January 10, 2019Date of Patent: January 28, 2020Assignee: Boehringer Ingelheim International GmbHInventors: Jean-Nicolas Desrosiers, Daniel Robert Fandrick, Nizar Haddad, Guisheng Li, Nitinchandra D. Patel, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake, Joshua Daniel Sieber, Zhulin Tan, Xiao-Jun Wang, Nathan K. Yee, Li Zhang, Yongda Zhang
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Publication number: 20190144475Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.Type: ApplicationFiled: January 10, 2019Publication date: May 16, 2019Inventors: Jean-Nicolas DESROSIERS, Daniel Robert FANDRICK, NIZAR HADDAD, Guisheng LI, Nitinchandra D. PATEL, Bo QU, Sonia RODRIGUEZ, Chris Hugh SENANAYAKE, Joshua Daniel SIEBER, Zhulin TAN, Xiao-Jun WANG, Nathan K. YEE, Li ZHANG, Yongda ZHANG
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Patent number: 10221203Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.Type: GrantFiled: December 6, 2017Date of Patent: March 5, 2019Assignee: Boehringer Ingelheim International GmbhInventors: Jean-Nicolas Desrosiers, Daniel Robert Fandrick, Nizar Haddad, Guisheng Li, Nitinchandra D. Patel, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake, Joshua Daniel Sieber, Zhulin Tan, Xiao-Jun Wang, Nathan K. Yee, Li Zhang, Yongda Zhang
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Publication number: 20180155375Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.Type: ApplicationFiled: December 6, 2017Publication date: June 7, 2018Inventors: Jean-Nicolas Desrosiers, Daniel Robert Fandrick, Nizar Haddad, Guisheng Li, Nitinchandra D. Patel, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake, Joshua Daniel Sieber, Zhulin Tan, Xiao-Jun Wang, Nathan K. Yee, Li Zhang, Yongda Zhang
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Patent number: 8648192Abstract: The present invention relates to a compound of formula (I) wherein R1, R2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I) as reagents in organic synthesis.Type: GrantFiled: May 23, 2011Date of Patent: February 11, 2014Assignee: Boehringer Ingelheim International GmbHInventor: Zhulin Tan
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Publication number: 20130203985Abstract: The present invention relates to a compound of formula (I) wherein R1, R2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I) as reagents in organic synthesis.Type: ApplicationFiled: May 23, 2011Publication date: August 8, 2013Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventor: Zhulin Tan
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Publication number: 20120136158Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.Type: ApplicationFiled: February 8, 2012Publication date: May 31, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
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Publication number: 20120035370Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.Type: ApplicationFiled: October 14, 2011Publication date: February 9, 2012Applicant: Boehringer Ingelheim International GmbHInventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
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Publication number: 20110275808Abstract: A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.Type: ApplicationFiled: April 28, 2009Publication date: November 10, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Jonathan Timothy Reeves, Jinhau J. Song, Zhulin Tan
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Publication number: 20110263844Abstract: The present invention is directed to a method for the preparation of macrocyclic compounds of formula (I), comprising the step of cyclizing a diene of formula (II), in the presence of a catalyst, wherein R1-R6, A, W and V are as defined herein. The present invention is also directed to intermediate compounds of formula II.Type: ApplicationFiled: May 5, 2009Publication date: October 27, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Chutian Shu, Chris Hugh Senanayake, Zhulin Tan, Nathan Yee, Xingzhong Zeng
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Publication number: 20110130578Abstract: A process for stereoselective synthesis of a compound of Formula (X) or Formula (X?) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C5 alkoxy, C1-C5 alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C1-C5 alkoxycarbonylamino, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or C1-C5 alkylthio wherein the sulfur atom is oxidized to sulfoxide or sulfone, and R2 and R3 are each independently hydrogen or C1-C5 alkyl.Type: ApplicationFiled: May 27, 2010Publication date: June 2, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Daniel R. FANDRICK, Daniel KUZMICH, Jonathan T. REEVES, Jinhua J. SONG, Zhulin TAN, Thomas LEE
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Publication number: 20110130567Abstract: A process for stereoselective synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; R2 and R3 are each independently C1-C5 alkyl; R4 is C1-C5 alkyl optionally independently substituted with one to three substituent groups, wherein each substituent group of R4 is independently C1-C3 alkyl, hydroxy, halogen, amino, or oxo; and R5 is a heteroaryl group substituted with one to three substituent groups, wherein each substituent group of R5 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialkyType: ApplicationFiled: May 27, 2010Publication date: June 2, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: DANIEL R. FANDRICK, JONATHAN T. REEVES, JINHUA J. SONG, ZHULIN TAN, BO QU, NATHAN K. YEE, SONIA RODRIGUEZ
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Patent number: 7884246Abstract: Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.Type: GrantFiled: November 1, 2006Date of Patent: February 8, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Fabrice Gallou, Heewon Lee, Chris Hugh Senanayake, Jinhua J. Song, Zhulin Tan, Jinghua Xu, Nathan K. Yee
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Patent number: 7879873Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.Type: GrantFiled: September 22, 2009Date of Patent: February 1, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Brian Nicholas Cook, Darren DiSalvo, Daniel Robert Fandrick, Christian Harcken, Daniel Kuzmich, Thomas Wai-Ho Lee, Pingrong Liu, John Lord, Can Mao, Jochen Neu, Brian Christopher Raudenbush, Hossein Razavi, Jonathan Timothy Reeves, Jinhua J. Song, Alan David Swinamer, Zhulin Tan
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Publication number: 20100093724Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.Type: ApplicationFiled: September 22, 2009Publication date: April 15, 2010Applicant: Boehringer Ingelheim International GmbHInventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
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Patent number: 7507843Abstract: A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.Type: GrantFiled: September 30, 2004Date of Patent: March 24, 2009Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Jinhua J. Song, Zhulin Tan, Jinghua Xu, Nathan K. Yee, Chris H. Senanayake