Patents by Inventor Zhuqing Liu

Zhuqing Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240131486
    Abstract: A full-electric drive cementing control system is disclosed.
    Type: Application
    Filed: March 15, 2022
    Publication date: April 25, 2024
    Applicant: YANTAI JEREH PETROLEUM EQUIPMENT & TECHNOLOGIES CO., LTD.
    Inventors: Pengyuan ZHANG, Kai WANG, Jihua WAN, Ren LIU, Jun WANG, Song ZHANG, Kaishen LIU, Shuzhen CUI, Zhuqing MAO, Weiwei LIU
  • Publication number: 20240067761
    Abstract: An invert emulsion having double particle size distribution, the invert emulsion having a particle size distribution of latex particles between 20 nm and 70 nm and between 100 nm and 500 nm in the same invert emulsion system. A preparation method for an invert emulsion comprises: forming an emulsion A and an emulsion B having different particle sizes by controlling an emulsifier system and an emulsification means, and preparing in one step an invert emulsion the particle size of which has bimodal distribution by means of a three-stage polymerization reaction between the emulsion A and the emulsion B in the same system. The invert emulsion is used as a water treatment flocculant, a sludge dewatering agent and a papermaking auxiliary agent, and in particular, the sludge dewatering agent fabricated from the invert emulsion is used for dewatering sludge.
    Type: Application
    Filed: April 12, 2021
    Publication date: February 29, 2024
    Inventors: Guofeng HE, Zhuqing LIU, Qiang LIU, Qin WANG, Tao ZHOU, Suling YIN
  • Patent number: 11767292
    Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: September 26, 2023
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R. Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Patent number: 11708371
    Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: July 25, 2023
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R. Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Publication number: 20230212048
    Abstract: Disclosed are a core-shell structure membrane scale inhibitor and a preparation method therefor, wherein the core-shell structure membrane scale inhibitor has a core emulsion obtained via emulsion polymerization, and a shell structure obtained via ultraviolet-light grafting functional monomers. The preparation method has first preparing a core by using an emulsion polymerization process, adding a reactive photo-initiator in the later stage of polymerization, so that the reactive photo-initiator is grafted on the surface of the core, and finally initiating the polymerization of functional monomers by means of ultraviolet light to obtain a core-shell structure membrane scale inhibitor. The surface structure of the core is modified, such that a large number of ionizable groups are grafted on the surface thereof, and thus, a large number of scaling ions such as Ca2+, Mg2+ and Al3+ can be adsorbed.
    Type: Application
    Filed: June 2, 2021
    Publication date: July 6, 2023
    Applicant: JIANGSU FEYMER TECHNOLOGY CO., LTD.
    Inventors: Guofeng HE, Zhuqing LIU, Qin WANG
  • Publication number: 20230174567
    Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3?-fluoro-thio-guanosine monophosphate or 3?-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 8, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Travis Armiger, Kevin M. Belyk, Tamas Benkovics, Cheol K. Chung, Yining Ji Chen, Heather Claire Johnson, Artis Klapars, Zhijian Liu, Zhuqing Liu, Jeffrey C. Moore, Andrew J. Neel, Feng Peng, Stephan M. Rummelt, Nastaran Salehi Marzuarani, Benjamin D. Sherry, Zhiguo Jake Song, Ben William Hulme Turnbull, Lu Wang, Feng Xu
  • Patent number: 11649243
    Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: May 16, 2023
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Feng Xu, Zhuqing Liu, Richard Desmond, Jeonghan Park, Alexei Kalinin, Birgit Kosjek, Hallena Strotman, Hongmei Li, Johannah Moncecchi
  • Publication number: 20220241362
    Abstract: A multi-efficacy traditional Chinese medicine compound composition and application thereof in pharmaceutical preparations are disclosed. The traditional Chinese medicine extracts are combined with the glucosamine, the collagen and the chondroitin sulfate, so that the multi-efficacy traditional Chinese medicine compound composition is prepared. The traditional Chinese medicine compound composition starts from improving the health of bone and joint and accompanying cardiovascular disease, selects the medicinal materials, and optimizes the extraction process of the traditional Chinese medicine for the diseases dominated by degenerative osteoarthritis. The disclosure has the efficacious of improving the symptoms of degenerative osteoarthritis, reducing blood pressure, improving the symptoms with osteoporosis, improving the symptoms with cardiovascular disease, improving the symptoms with urinary system disease, etc.
    Type: Application
    Filed: March 26, 2021
    Publication date: August 4, 2022
    Inventors: Shengcan Zou, Zengliang Zhang, Min Wang, Zhuqing Liu, Sai Lu, Li Li, Shanglong Wang
  • Publication number: 20220087926
    Abstract: A compound composition with anti-oxidation and anti-aging effects and preparation method and application thereof we disclosed. 5-8 kinds of traditional Chinese medicine extracts from separate extraction of Panax ginseng C. A. Meyer, Poria, Rehmannia glutinosa, Cistanche deserticola Ma, Salviae Miltiorrhizae, Codonopsis Radix, Persicae Semen and Ophiopogon japonicus (Linn.f.) Ker-Gawl. are compounded with chitooligosaccharide to prepare the compound composition with anti-oxidation and anti-aging effects. The compound composition has no toxic side effects, is easy to be absorbed, and can be used for delaying aging, repairing DNA damage and anti-oxidation damage, and can also reduce the risk of geriatric diseases. Moreover, the compound composition can be used as a raw material of dietary supplement or health food to improve telomerase content and delay aging. Therefore, the compound composition is suitable for promotion and application.
    Type: Application
    Filed: March 22, 2021
    Publication date: March 24, 2022
    Inventors: Shengcan Zou, Zengliang Zhang, Min Wang, Sai Lu, Zhuqing Liu, Jiancheng Zong, Shanglong Wang
  • Publication number: 20220073459
    Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
    Type: Application
    Filed: September 17, 2021
    Publication date: March 10, 2022
    Inventors: John Y.L. CHUNG, Kevin CAMPOS, Edward CLEATOR, Robert F. DUNN, Andrew GIBSON, R. Scott HOERRNER, Stephen KEEN, Dave LIEBERMAN, Zhuqing LIU, Joseph LYNCH, Kevin M. MALONEY, Feng XU, Nobuyoshi YASUDA, Naoki YOSHIKAWA, Yong-Li ZHONG
  • Publication number: 20220073523
    Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
    Type: Application
    Filed: August 11, 2021
    Publication date: March 10, 2022
    Inventors: Feng XU, Zhuqing LIU, Richard DESMOND, Jeonghan PARK, Alexei KALININ, Birgit KOSJEK, Hallena STROTMAN, Hongmei LI, Johannah MONCECCHI
  • Patent number: 11259096
    Abstract: An Html5-based audio/video playing method includes: based on a playing scenario, downloading audio/video data under the playing scenario; performing format conversion on the audio/video data; and loading the audio/video data after format conversion into an Html5 player.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: February 22, 2022
    Assignee: WANGSU SCIENCE & TECHNOLOGY CO., LTD.
    Inventors: Yupeng Jiang, Longshi Cai, Zhuqing Liu, Shaobin Wu
  • Publication number: 20210360269
    Abstract: A method for assigning a transcoding task includes: after receiving a task assignment request sent by a client device, the scheduling device may determine the current load value of each transcoding device according to the target resolutions of the transcoding tasks carried in each transcoding device and the device performance of each transcoding device, and further determine a target transcoding device whose current load value is less than a first threshold, to allow the client device to send a transcoding task to the target transcoding device.
    Type: Application
    Filed: September 26, 2018
    Publication date: November 18, 2021
    Inventors: Huijie ZHENG, Zhuqing LIU, Junming LI
  • Patent number: 11124478
    Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: September 21, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R. Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Patent number: 11091493
    Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KED) biocatalyst enzymes and methods of using the biocatalysts.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: August 17, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Feng Xu, Zhuqing Liu, Richard Desmond, Jeonghan Park, Alexei Kalinin, Birgit Kosjek, Hallena Strotman, Hongmei Li, Johannah Moncecchi
  • Publication number: 20210221815
    Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
    Type: Application
    Filed: January 22, 2021
    Publication date: July 22, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: John Y.L. CHUNG, Kevin CAMPOS, Edward CLEATOR, Robert F. DUNN, Andrew GIBSON, R. Scott HOERRNER, Stephen KEEN, Dave LIEBERMAN, Zhuqing LIU, Joseph LYNCH, Kevin M. MALONEY, Feng XU, Nobuyoshi YASUDA, Naoki YOSHIKAWA, Yong-Li ZHONG
  • Publication number: 20210168464
    Abstract: An Html5-based audio/video playing method includes: based on a playing scenario, downloading audio/video data under the playing scenario; performing format conversion on the audio/video data; and loading the audio/video data after format conversion into an Html5 player.
    Type: Application
    Filed: May 23, 2017
    Publication date: June 3, 2021
    Inventors: Yupeng JIANG, Longshi CAI, Zhuqing LIU, Shaobin WU
  • Patent number: 10899771
    Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: January 26, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R. Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Publication number: 20200392141
    Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 17, 2020
    Inventors: Feng XU, Zhuqing LIU, Richard Desmond, Jeonghan PARK, Alexei KALININ, Birgit KOSJEK, Hallena STROTMAN, Hongmei LI, Johannah MONCECCHI
  • Publication number: 20200290962
    Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:
    Type: Application
    Filed: February 20, 2020
    Publication date: September 17, 2020
    Inventors: John Y.L. CHUNG, Kevin CAMPOS, Edward CLEATOR, Robert F. DUNN, Andrew GIBSON, R. Scott HOERRNER, Stephen KEEN, Dave LIEBERMAN, Zhuqing LIU, Joseph LYNCH, Kevin M. MALONEY, Feng XU, Nobuyoshi YASUDA, Naoki YOSHIKAWA, Yong-Li ZHONG