Patents by Inventor Ziyuan DI

Ziyuan DI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I
    Patent number: 9815848
    Abstract: This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: November 14, 2017
    Assignees: TIANJIN UNIVERSITY, SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD
    Inventors: Junbo Gong, Qi Wang, Qiuxiang Yin, Jingkang Wang, Xiaopeng Song, Baohong Hou, Liting Liao, Duanming Tan, Ziyuan Di
  • Method For Preparing Spherical Clopidogrel Hydrogen Sulfate Polymorph I
    Publication number: 20170037054
    Abstract: This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.
    Type: Application
    Filed: December 31, 2014
    Publication date: February 9, 2017
    Inventors: Junbo GONG, Qi WANG, Qiuxiang YIN, Jingkang WANG, Xiaopeng Song, Baohong HOU, Liting LIAO, Duanming TAN, Ziyuan DI