Patents by Inventor Zongxing Qiu

Zongxing Qiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine compounds for the treatment of autoimmune disease
    Patent number: 11952363
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: April 9, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Fabian Dey, Zongxing Qiu, Wei Zhu, Ge Zou
  • Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof
    Publication number: 20230348467
    Abstract: The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in particular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.
    Type: Application
    Filed: January 12, 2021
    Publication date: November 2, 2023
    Applicants: Zhejiang Hisun Pharmaceutical Co., Ltd., Hisun AccuRay Therapeutics Co., Ltd.
    Inventors: Xiangui Huang, Yanghui Guo, Zongxing Qiu, Pingyan Bie, Weiwei Liao, Qingyan Yan, Weichao Shen, Hai Cao, Qingna Xing, Xin Wang, Qi Cao, Lichen Meng, Nuoyi Wu, Wenpeng Li, Cheng Ye, Taishan Hu, Lei Chen
  • QUINOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20230144399
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R11 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 14, 2018
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Zongxing QIU, Guolong WU, Dongdong CHEN, Chao LI
  • Cyclic amidine compounds for the treatment of autoimmune disease
    Patent number: 11548884
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as antagonist of TLR7 and/or TLR8 and/or TLR9 in the treatment of autoimmune diseases as well as auto-inflammation diseases.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 10, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zongxing Qiu, Hong Shen, Wei Zhu, Fabian Dey, Ge Zou, Hongtao Xu
  • SUBSTITUTED 3,4-DIHYDROQUINAZOLINE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220388969
    Abstract: The present invention provides novel compounds having the general formula (I) wherein R1 to R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 28, 2020
    Publication date: December 8, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Wenming CHEN, Song FENG, Chao LI, Zongxing QIU, Xuefei TAN, Guolong WU
  • QUINAZOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20220348549
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R6 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 26, 2020
    Publication date: November 3, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Song FENG, Chungen LIANG, Chao LI, Zongxing QIU, Xuefei TAN, Guolong WU
  • CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20210340134
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as antagonist of TLR7 and/or TLR8 and/or TLR9 in the treatment of autoimmune diseases as well as auto-inflammation diseases.
    Type: Application
    Filed: September 6, 2018
    Publication date: November 4, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zongxing Qiu, Hong Shen, Wei Zhu, Fabian Dey, Ge Zou, Hongtao Xu
  • PIPERAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20210269423
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: July 22, 2019
    Publication date: September 2, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: FABIAN DEY, ZONGXING QIU, WEI ZHU, GE ZOU
  • Pyridazinone-based broad spectrum anti-influenza inhibitors
    Patent number: 10597380
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: March 24, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John G. Cumming, Xianfeng Lin, Haixia Liu, Isabel Najera, Zongxing Qiu, Virginie Sandrin, Guozhi Tang, Guolong Wu
  • PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS
    Publication number: 20190127349
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: December 19, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: John G. CUMMING, Xianfeng LIN, Haixia LIU, Isabel NAJERA, Zongxing QIU, Virginie SANDRIN, Guozhi TANG, Guolong WU
  • 4-methyl-dihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
    Patent number: 9856247
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: January 2, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20170334898
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 28, 2015
    Publication date: November 23, 2017
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9447086
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: September 20, 2016
    Assignee: Hoffmann-LA Roche INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Xianfeng Lin, Haixia Liu, Alexander V Mayweg, Zongxing Qiu, Hong Shen, Guozhi Tang, Lisha Wang, Guolong Wu, Shixiang Yan, Weixing Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160237078
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 18, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Xianfeng Lin, Haixia Liu, Alexander V Mayweg, Zongxing Qiu, Hong Shen, Guozhi Tang, Lisha Wang, Guolong Wu, Shixiang Yan, Weixing Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160052921
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 28, 2015
    Publication date: February 25, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • Novel 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20150031687
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2013
    Publication date: January 29, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Xianfeng Lin, Haixia Liu, Alexander V Mayweg, Zongxing Qiu, Hong Shen, Guozhi Tang, Lisha Wang, Guolong Wu, Shixiang Yan, Weixing Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20130267517
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 10, 2013
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • 4-amino-N-hydroxy-benzamides for the treatment of cancer
    Patent number: 8404738
    Abstract: The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: March 26, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Jason Christopher Wong, Zhenshan Zhang
  • NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER
    Publication number: 20120190700
    Abstract: The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 26, 2012
    Inventors: Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Jason Christopher Wong, Zhenshan Zhang
  • COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA
    Publication number: 20110195979
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
    Type: Application
    Filed: February 7, 2011
    Publication date: August 11, 2011
    Inventors: Li Chen, Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Lisha Wang, Jim Zhen Wu, Wengang Yang