Patents by Inventor Zora D. Modrusan

Zora D. Modrusan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting vancomycin-resistant microorganisms and compositions therefor
    Patent number: 7122314
    Abstract: A method for detecting the presence of a vancomycin-resistant microorganism in a biological sample using a single chimeric probe in a cycling probe reaction.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: October 17, 2006
    Assignee: ID Biomedical Corporation
    Inventor: Zora D Modrusan
  • Methods for detecting vancomycin-resistant microorganisms and compositions therefor
    Publication number: 20040096937
    Abstract: A method for detecting the presence of a vancomycin-resistant microorganism in a biological sample using a single chimeric probe in a cycling probe reaction.
    Type: Application
    Filed: January 30, 2003
    Publication date: May 20, 2004
    Applicant: ID Biomedical Corporation
    Inventor: Zora D. Modrusan
  • Compositions and methods for detecting vancomycin resistant enterococci by cycling probe reactions
    Patent number: 6274316
    Abstract: A method for determining the presence of vancomycin antibiotic resistant gene of enterococci in a biological sample, comprising the steps of (a) treating cells contained within the biological sample to expose single stranded-target nucleic acid molecules; (b) reacting the target single-stranded cellular nucleic acids with probe(s) nucleic acid sequence complementary to a portion of the antibiotic vancomycin resistant gene and the probe having a scissile linkage, and with an enzyme molecule, under conditions, which allow the target and probe to hybridize to each other and form a double-stranded, target-probe complex, the enzyme molecule being capable of cleaving the scissile link of the target-probe complex such that one or more fragments of the nucleic acid probe is released from said complex; and (c) determining whether cleaved portions of the nucleic acid probe are produced, and thereby detecting the presence of a vancomycin antibiotic resistant gene.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: August 14, 2001
    Assignee: ID Biomedical Corporation
    Inventor: Zora D. Modrusan
  • Additives for use in cycling probe reactions
    Patent number: 6136533
    Abstract: A method for detecting a target nucleic acid molecule is provided, comprising the steps of (a) reacting a mixture comprising (i) a target nucleic acid molecule; (ii) a single-stranded nucleic acid probe containing a scissile linkage; (iii) an enzyme capable of cleaving the probe portion of a double-stranded target-probe complex at the scissile linkage; and (iv) ribosomal protein and/or spermine, under conditions and for a time sufficient to allow the target nucleic acid and probe to hybridize to each other and form a double-stranded target-probe complex, followed by cleavage of the probe and cycling of the target to a new uncleaved probe, such that one or more portions of the cleaved nucleic acid probe are released from the target-probe complex; and (b) determining whether cleaved portions of the nucleic acid probe are produced, and thereby detecting the presence of the target nucleic acid.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: October 24, 2000
    Assignee: ID Biomedical
    Inventors: Faouzi Bekkaoui, Zora D. Modrusan, Isabelle A. Piche, Peter D. Duck, Lynn P. Cloney, Alfred C. K. Wong