Patents by Inventor Zsolt Dombrady

Zsolt Dombrady has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of dronedarone by removal of hydroxyl group
    Patent number: 9701654
    Abstract: The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof the hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: July 11, 2017
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Dombrády
  • Process for preparation of dronedarone by N-butylation
    Patent number: 9611242
    Abstract: The invention relates to a compound of formula (II) and salts thereof. Also described herein are processes for the preparation of a compound of formula (II) and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: April 4, 2017
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Párkányi, Zsolt Dombrády
  • PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP
    Publication number: 20160272606
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.
    Type: Application
    Filed: June 1, 2016
    Publication date: September 22, 2016
    Inventors: Csaba HUSZÁR, Adrienn HEGEDUS, Zsolt DOMBRÁDY
  • Process for preparation of dronedarone by oxidation of a hydroxyl group
    Patent number: 9382223
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof (formula I), which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: July 5, 2016
    Assignee: SANOFI
    Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
  • PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP
    Publication number: 20160075674
    Abstract: The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof the hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 17, 2016
    Inventors: Antal FRIESZ, Zsolt DOMBRÁDY
  • Process for the preparation of dronedarone by oxidation of a sulphenyl group
    Patent number: 9249119
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: February 2, 2016
    Assignee: SANOFI
    Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
  • Process for preparation of dronedarone by Grignard reaction
    Patent number: 9238636
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof, which comprises reacting of compound of formula (IV) with compound of formula (VI) in a Grignard reaction, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and processes for the preparation thereof.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: January 19, 2016
    Assignee: SANOFI
    Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
  • PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION
    Publication number: 20160009679
    Abstract: The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3—CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.
    Type: Application
    Filed: September 23, 2015
    Publication date: January 14, 2016
    Inventors: Antal FRIESZ, Zsolt PÁRKÁNYI, Zsolt DOMBRÁDY
  • PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP
    Publication number: 20160009678
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof (formula I), which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 14, 2016
    Applicant: SANOFI
    Inventors: Csaba HUSZÁR, Adrienn HEGEDUS, Zsolt DOMBRÁDY
  • Process for preparation of dronedarone by removal of hydroxyl group
    Patent number: 9221778
    Abstract: The invention relates to a process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that from the compound of formula (II). The hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: December 29, 2015
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Dombrády
  • Process for preparation of dronedarone by N-butylation
    Patent number: 9174959
    Abstract: The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3—CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 3, 2015
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Párkányi, Zsolt Dombrády
  • PROCESS FOR PREPARATION OF DRONEDARONE BY GRIGNARD REACTION
    Publication number: 20150274688
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof, which comprises reacting of compound of formula (IV) with compound of formula (VI) in a Grignard reaction, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and processes for the preparation thereof.
    Type: Application
    Filed: May 23, 2013
    Publication date: October 1, 2015
    Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
  • PROCESS FOR THE PREPARATION OF DRONEDARONE BY OXIDATION OF A SULPHENYL GROUP
    Publication number: 20150031902
    Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 29, 2015
    Applicant: SANOFI
    Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
  • PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP
    Publication number: 20150005515
    Abstract: The invention relates to a process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that from the compound of formula (II). the hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 1, 2015
    Inventors: Antal Friesz, Zsolt Dombrády
  • Process for the preparation of dronedarone
    Patent number: 8889734
    Abstract: The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: November 18, 2014
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Dombrady, Mariann Csatarine Nagy
  • PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION
    Publication number: 20140114081
    Abstract: The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3—CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.
    Type: Application
    Filed: March 27, 2012
    Publication date: April 24, 2014
    Applicant: SANOFI
    Inventors: Antal Friesz, Zsolt Párkányi, Zsolt Dombrády
  • PROCESS FOR THE PREPARATION OF DRONEDARONE
    Publication number: 20130261321
    Abstract: The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 3, 2013
    Inventors: Antal FRIESZ, Zsolt DOMBRADY, Mariann CSATARINE NAGY
  • Process for the preparation of dronedarone
    Patent number: 8501971
    Abstract: The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: August 6, 2013
    Assignee: Sanofi
    Inventors: Antal Friesz, Zsolt Dombrady, Mariann Csatarine Nagy
  • NEW PROCESS FOR THE PREPARATION OF DRONEDARONE
    Publication number: 20120289717
    Abstract: The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 15, 2012
    Applicant: SANOFI
    Inventors: Antal FRIESZ, Zsolt DOMBRADY, Mariann CSATARINE NAGY
  • Chloromethylation of thiophene
    Patent number: 7462725
    Abstract: The process according to the invention relates to the preparation of 2-chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II). Compounds of formula (I) and (II) are intermediates of several pharmaceutically active ingredients.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: December 9, 2008
    Assignee: Sanofi-Aventis
    Inventors: Mátyás Aradi, Ferenc Bakos, Zsolt Dombrády, Antal Gajáry, István Gyöngyösi, Ferenc Kovács, Andrea Major, Erika Máténé Török, Zsolt Párkányi, László Schultz, Attila Supic, Sándor Szabó, Erzsébet Szalay, József Ugrics, József Zsiga