Abstract: A device for filling and withdrawing gas includes a withdrawing circuit provided with a storage connector that can be connected to a storage container and a withdrawing connector that can be connected to a withdrawing device. The device also includes a filling circuit provided with a filling connector that can be connected to a gas source for filling the container. The filling connector includes a piston internally defining a filling duct and having a drain orifice opening transversely into said filling duct. The piston is movable inside a drain body provided with a drain duct connected to a leakage circuit connected to the outside, between an open position wherein the drain orifice does not coincide with the drain duct and a closed position wherein the drain orifice coincides with the drain duct to establish communication between said filling duct and the leakage circuit.

Abstract: A pressure regulator includes a downstream body delimiting a low pressure chamber; an upstream body delimiting a high pressure chamber and carrying an expansion seat; a movable piston having an inner channel having an upper end forming a discharging seat and a lower end opening onto an intermediate chamber connected to a leakage circuit; a tubular valve rod passing through the inner channel of the piston and an inner channel of the upstream body, having an upper end forming a discharging valve and a lower end forming a regulating flap suitable for bearing on the expansion seat; a first biasing member compressed between the piston and the upstream body by biasing the piston towards the downstream body; and a second biasing member compressed between the piston and a plate secured to the valve rod, biasing the rod in the direction of pressing the discharging valve against the discharging seat.

Abstract: A pressure regulator includes a downstream body delimiting a low pressure chamber; an upstream body delimiting a high pressure chamber and carrying an expansion seat; a movable piston having an inner channel having an upper end forming a discharging seat and a lower end opening onto an intermediate chamber connected to a leakage circuit; a tubular valve rod passing through the inner channel of the piston and an inner channel of the upstream body, having an upper end forming a discharging valve and a lower end forming a regulating flap suitable for bearing on the expansion seat; a first biasing member compressed between the piston and the upstream body by biasing the piston towards the downstream body; and a second biasing member compressed between the piston and a plate secured to the valve rod, biasing the rod in the direction of pressing the discharging valve against the discharging seat.

Abstract: A device for filling and withdrawing gas includes a withdrawing circuit provided with a storage connector that can be connected to a storage container and a withdrawing connector that can be connected to a withdrawing device. The device also includes a filling circuit provided with a filling connector that can be connected to a gas source for filling the container. The filling connector includes a piston internally defining a filling duct and having a drain orifice opening transversely into said filling duct. The piston is movable inside a drain body provided with a drain duct connected to a leakage circuit connected to the outside, between an open position wherein the drain orifice does not coincide with the drain duct and a closed position wherein the drain orifice coincides with the drain duct to establish communication between said filling duct and the leakage circuit.

Abstract: The invention relates to a tap including a body, which is provided with a gas inlet that is to be connected to the storage space of a container, a bleed-off circuit, including a downstream end, characterized in that the tap further includes a circuit for selectively controlling the movement of the isolation valve into the first position for opening the bleed-off circuit, the control circuit including a first end connected to the valve, and a second end that can be selectively coupled to an actuator of a gas bleed-off member, in order to selectively electrically control the movement of the valve into the position for opening the bleed-off circuit.

Abstract: The present invention is related to a pharmaceutical formulation containing ramipril with improved stability, which comprises ramipril and a desintegrant directly granulated with a binder.

Abstract: The invention relates to a tap including a body, which is provided with a gas inlet that is to be connected to the storage space of a container, a bleed-off circuit, including a downstream end, characterized in that the tap further includes a circuit for selectively controlling the movement of the isolation valve into the first position for opening the bleed-off circuit, the control circuit including a first end connected to the valve, and a second end that can be selectively coupled to an actuator of a gas bleed-off member, in order to selectively electrically control the movement of the valve into the position for opening the bleed-off circuit.

Abstract: The present invention relates to a process for manufacturing microcrystalline ezetimibe containing granulate, wherein a) ezetimibe is dissolved; b) the dissolved ezetimibe is precipitated with water, which if necessary contains pharmaceutical excipients, preferably lauryl-sulfate derivatives, and c) granulates are formed from the obtained suspension by spraying the suspension onto pharmaceutical excipients. A further aspect of the present invention is the granulate obtained by the present process and the pharmaceutical composition containing such granulate.

Abstract: Prasugrel containing quickly released stable oral pharmaceutical compositions containing micronized prasugrel base, and starch or a starch derivative, and processes for the preparation thereof, and the use thereof for treating atherothrombotic events of patients suffering from acute coronary syndrome in which patients were subjected to percutaneous coronary intervention.

Abstract: The present invention relates to a process for manufacturing microcrystalline ezetimibe containing granulate, wherein a) ezetimibe is dissolved; b) the dissolved ezetimibe is precipitated with water, which if necessary contains pharmaceutical excipients, preferably lauryl-sulfate derivatives, and c) granulates are formed from the obtained suspension by spraying the suspension onto pharmaceutical excipients. A further aspect of the present invention is the granulate obtained by the present process and the pharmaceutical composition containing such granulate.

Abstract: The invention relates to tablets comprising deramciclane-fumarate of the Formula (I) whereby said tablets contain (related to the total weight) more than 50% by weight of deramciclane-fumarate, 5-20% by weight of a 5-20% by weight of microcrystalline cellulose having an average particle size below 30 ?m, 1-10% by weight of a disintegrant, 0.54% by weight of a lubricant, 0.54% by weight of an anti-adhesive agent and 0-30% by weight of a filler. ingredient.